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Plasma Levels of Antidiuretic Hormone in Patients Receiving Prolonged Lithium Therapy

Published online by Cambridge University Press:  29 January 2018

P. L. Padfield ,
S. J. Park ,
J. J. Morton  and
A. E. Braidwood
P. L. Padfield
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
S. J. Park
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
J. J. Morton
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
A. E. Braidwood
Affiliation:
Medical Research Council, Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT; and Gartnavel Royal Psychiatric Hospital, Glasgow G12 0XH
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Summary

Among 18 patients receiving prophylactic, long-term lithium treatment for manic-depressive psychosis, a high incidence of increased thirst and frequency of micturition (60–70 per cent) was noted on direct questioning. Symptoms arose at varying times after the start of lithium therapy; in no patient did symptoms antedate the use of the drug.

Plasma levels of antidiuretic hormone were found, on average, to be higher than in normal control subjects for a given level of plasma osmolality, although the scatter of results was wide. It is suggested that elevation of antidiuretic hormone occurs as a compensatory mechanism for the polyuria which is a common feature of long-term lithium treatment. The more florid form of nephrogenic diabetes insipidus occasionally seen in lithium takers seems likely to be due to a different mechanism from the more common mild polyuria.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 2 , February 1977 , pp. 144 - 147
Copyright
Copyright © Royal College of Psychiatrists 1977 

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