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Neural correlates of reward in autism

  • Nicole Schmitz (a1), Katya Rubia (a2), Therese van Amelsvoort (a3), Eileen Daly (a4), Anna Smith (a4) and Declan G. M. Murphy (a5)...



Lack of social interaction, which is characteristically seen in people with autistic-spectrum disorder, may be caused by malfunctioning of the frontostriatal reward systems. However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder.


To investigate functional brain activation during reward feedback in people with autistic-spectrum disorder and control individuals.


We used event-related functional magnetic resonance imaging to examine the neural substrates of monetary reward in individuals with autistic-spectrum disorder and matched controls.


When rewarded, individuals with autism compared with control individuals showed significantly greater brain activation in the left anterior cingulate gyrus. In addition, activation of this region was negatively correlated with social interaction as measured by the Autism Diagnostic Interview.


In people with autistic-spectrum disorder, achieving reward is associated with significant differences in the activation of areas known to be responsible for attention and arousal, and this may partially underpin some deficits in social behaviour.

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Corresponding author

Dr Nicole Schmitz, Academisch Psychiatrisch Centrum, Meibergdreef 5, Adolescentenkliniek/PA3-136, 1105 AZ Amsterdam, The Netherlands. Email:


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Declaration of interest


Funding detailed in Acknowledgements.



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1 Wing, L. The autistic spectrum. Lancet 1997; 350: 1761–6.
2 Gillberg, C. Autism and related behaviors. J Intellect Disabil Res 1993; 37: 343–72.
3 Jarbrink, K, Knapp, M. The economic impact of autism in Britain. Autism 2001; 5: 722.
4 Garretson, HB, Fein, D, Waterhouse, L. Sustained attention in children with autism. J Autism Dev Disord 1990; 20: 101–14.
5 Dawson, G, Osterling, J, Rinaldi, J, Carver, L, McPartland, J. Brief report. Recognition memory and stimulus reward associations: indirect support for the role of ventromedial prefrontal dysfunction in autism. J Autism Dev Disord 2001; 31: 337–41.
6 Courchesne, E, Pierce, K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr Opin Neurobiol 2005; 15: 225–30.
7 Bauman, ML, Kemper, TL. Neuroanatomic observations of the brain in autism: a review and future directions. Int J Dev Neurosci 2005; 23: 183–7.
8 McAlonan, GM, Cheung, V, Cheung, C, Suckling, J, Lam, GY, Tai, KS, Yip, L, Murphy, DG, Chua, SE. Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain 2005; 128: 268–76.
9 Abell, F, Krams, M, Ashburner, J, Passingham, R, Friston, K, Frackowiak, R, Happe, F, Frith, C, Frith, U. The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans. Neuroreport 1999; 10: 1647–51.
10 Piven, J, Berthier, ML, Starkstein, SE, Nehme, E, Pearlson, G, Folstein, S. Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. Am J Psychiatry 1990; 147: 734–9.
11 Schultz, RT, Gauthier, I, Klin, A, Fulbright, RK, Anderson, AW, Volkmar, F, Skudlarski, P, Lacadie, C, Cohen, DJ, Gore, JC. Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch Gen Psychiatry 2000; 57: 331–40.
12 Lord, C, Rutter, M, Le Couteur, A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24: 659–85.
13 World Healh Organization. The ICD-10 Classification of Mental and Behavioural Disorders. World Healh Organization, 1992.
14 Crawford, JR, Mychalkiw, B, Johnson, DA, Moore, JW. WAIS-R short-forms: criterion validity in healthy and clinical samples. Br J Clin Psychol 1996; 35: 638–40.
15 Burock, MA, Buckner, RL, Woldorff, MG, Rosen, BR, Dale, AM. Randomized event-related experimental designs allow for extremely rapid presentation rates using functional MRI. Neuroreport 1998; 9: 3735–9.
16 Dale, AM. Optimal experimental design for event-related fMRI. Hum Brain Mapp 1999; 8: 109–14.
17 Rubia, K, Smith, AB, Woolley, J, Nosarti, C, Heyman, I, Taylor, E, Brammer, M. Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive control. Hum Brain Mapp 2006; 27: 973–93.
18 Talairach, J, Tournoux, P. Co-Planar Stereotactic Atlas of the Human Brain: 3-Dimensional Proportional System: An approach to Cerebral Imaging. Thieme, 1988.
19 Brodmann, K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Principien, dargestellt auf grund des Zellenbaues [Comparative Localisation Evidence for the Cortex, Explained and Depicted by Cell Structure] (2nd edn). Johann Ambrosius Barth Verlag, 1925.
20 Brett, M, Johnsrude, IS, Owen, AM. The problem of functional localization in the human brain. Nat Rev Neurosci 2002; 3: 243–9.
21 Ashburner, J, Friston, KJ. Unified segmentation. Neuroimage 2005; 26: 839–51.
22 Pochon, JB, Levy, R, Fossati, P, Lehericy, S, Poline, JB, Pillon, B, Le Bihan, D, Dubois, B. The neural system that bridges reward and cognition in humans: an fMRI study. Proc Natl Acad Sci USA 2002; 99: 5669–74.
23 Mottaghy, FM, Willmes, K, Horwitz, B, Mueller, HW, Krause, BJ, Sturm, WJ. Systems level modeling of a neuronal network subserving intrinsic alertness. Neuroimage 2006; 29: 225–33.
24 Bush, G, Luu, P, Posner, MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000; 4: 215–22.
25 Bloom, JS, Hynd, GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neurpsychol Rev 2005; 15: 5971.
26 Rogers, RD, Ramnani, N, Mackay, C, Wilson, JL, Jezzard, P, Carter, CS, Smith, SM. Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition. Biol Psychiatry 2004; 15: 594602.
27 Kirsch, P, Schienle, A, Stark, R, Sammer, G, Blecker, C, Walter, B, Ott, U, Burkart, J, Vaitl, D. Anticipation of reward in a nonaversive differential conditioning paradigm and the brain reward system: an event-related fMRI study. Neuroimage 2003; 20: 1086–95.
28 Ohnishi, T, Matsuda, H, Hashimoto, T, Kunihiro, T, Nishikawa, M, Uema, T, Sasaki, M. Abnormal regional cerebral blood flow in childhood autism. Brain 2000; 123: 1838–44.
29 Happe, F, Ehlers, S, Fletcher, P, Frith, U, Johansson, M, Gillberg, C, Dolan, R, Frackowiak, R, Frith, C. ‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome. Neuroreport 1996; 8: 197201.
30 Luna, B, Minshew, NJ, Garver, KE, Lazar, NA, Thulborn, KR, Eddy, WF, Sweeney, JA. Neocortical system abnormalities in autism: an fMRI study of spatial working memory. Neurology 2002; 59: 834–40.
31 Waiter, GD, Williams, JH, Murray, AD, Gilchrist, A, Perrett, DI, Whiten, A. Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation. Neuroimage 2005; 24: 455–61.
32 Allman, JM, Watson, KK, Tetreault, NA, Hakeem, AY. Intuition and autism: a possible role for Von Economo neurons. Trends Cogn Sci 2005; 9: 367–73.
33 Murphy, DG, Daly, E, Schmitz, N, Toal, F, Murphy, K, Curran, S, Erlandsson, K, Eersels, J, Kerwin, R, Ell, P, Travis, M. Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study. Am J Psychiatry 2006; 163: 934–6.
34 Haznedar, MM, Buchsbaum, MS, Hazlett, EA, LiCalzi, EM, Cartwright, C, Hollander, E. Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. Am J Psychiatry 2006; 163: 1252–63.
35 Haznedar, MM, Buchsbaum, MS, Metzger, M, Solimando, A, Spiegel-Cohen, J, Hollander, E. Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. Am J Psychiatry 1997; 154: 1047–50.
36 Delgado, MR, Labouliere, CD, Phelps, EA. Fear of losing money? Aversive conditioning with secondary reinforcers. Soc Cogn Affect Neurosci 2006; 1: 250–9.
37 Chung, MK, Dalton, KM, Alexander, AL, Davidson, RJ. Less white matter concentration in autism: 2D voxel-based morphometry. Neuroimage 2004; 23: 242–51.
38 Schmitz, N, Rubia, K, Daly, E, Smith, A, Williams, S, Murphy, DG. Neural correlates of executive function in autistic spectrum disorders. Biol Psychiatry 2006; 59: 716.
39 Sowell, ER, Thompson, PM, Holmes, CJ, Jernigan, TL, Toga, AW. In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nat Neurosci 1999; 2: 859–61.
40 Paus, T, Koski, L, Caramanos, Z, Westbury, C. Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies. Neuroreport 1998; 9: R37R47.
41 Baron-Cohen, S, Ring, HA, Wheelwright, S, Bullmore, ET, Brammer, MJ, Simmons, A, Williams, SC. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci 1999; 11: 1891–8.
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Neural correlates of reward in autism

  • Nicole Schmitz (a1), Katya Rubia (a2), Therese van Amelsvoort (a3), Eileen Daly (a4), Anna Smith (a4) and Declan G. M. Murphy (a5)...
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