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Monoamine Oxidase (Mao) of Platelets, Plasma, Lymphocytes and Granulocytes in Schizophrenia

  • Peter A. Bond (a1), Richard L. Cundall (a1) and Ian R. H. Falloon (a1)

Summary

Monoamine oxidase (MAO) levels in plasma, platelets, lymphocytes and granulocytes have been compared in schizophrenics and controls using three substrates. No significant difference was found between MAO levels in controls and the schizophrenic group as a whole, but platelets and lymphocytes of the latter (tyramine or benzylamine substrate) showed greater variation and in some cases higher values than controls, irrespective of treatment. Schizophrenics who experienced auditory hallucinations had significantly lower MAO levels in lymphocytes and platelets than those who did not.

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Belmaker, R., Murphy, D. L., Wyatt, R. J. & Loriaux, L. (1974) Human platelet monoamine oxidase changes during the menstrual cycle. Archives of General Psychiatry, 31, 553–6.
Berger, P. A., Ginsburg, R. A., Barchas, J. D., Murphy, D. L. & Wyatt, R. J. (1978) Platelet monoamine oxidase in chronic schizophrenic patients. American Journal of Psychiatry, 135, 95–9.
Bond, P. A. & Cundall, R. L. (1977) Properties of monoamine oxidase (MAO) in human blood platelets, plasma, lymphocytes and granulocytes. Clinica Chimica Acta, 80, 317–26.
Boyum, A. (1974) Separation of blood leucocytes, granulocytes and lymphocytes. Tissue Antigens, 4, 269–74.
Brockington, I., Crow, T. J., Johnstone, E. C. & Owen, F. (1976) An investigation of platelet monoamine oxidase activity. In Schizophrenia and Schizoaffective Psychosis. CIBA Foundation Symposium, 39, 353–69.
Friedman, E., Shopsin, B., Sathananthan, G. & Gershon, S. (1974) Blood platelet monoamine oxidase activity in psychiatric patients. American Journal of Psychiatry, 131, 1392–4.
Meltzer, H. Y. & Stahl, S. M. (1974) Platelet monoamine oxidase activity and substrate preferences in schizophrenic patients. Research Communications in Chemical Pathology and Pharmacology, 7, 419–31.
Murphy, D. L. & Wyatt, R. J. (1972) Reduced monoamine oxidase activity in blood platelets from schizophrenic patients. Nature (London), 238, 225–6.
Murphy, D. L., Belmaker, R., Carpenter, W. T. & Wyatt, R. J. (1977) Monoamine oxidase in chronic schizophrenia. Studies of hormonal and other factors affecting enzyme activity. British Journal of Psychiatry, 130, 151–8.
Murphy, D. L., Donnelly, C. H., Miller, L. & Wyatt, R. J. (1976) Platelet monoamine oxidase in schizophrenia. Some enzyme characteristics relevant to reduced activity. Archives of General Psychiatry, 33, 1377–81.
Nies, A., Robinson, D. S., Harris, L. S. & Lamborn, K. R. (1974) Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives and controls. In Neuropsychopharmacology of Monoamines and their Regulatory Enzymes. 5970. Raven Press.
Owen, F., Bourne, R., Crow, T. J., Johnstone, E. C., Bailey, A. R. & Hershon, H. I. (1976) Platelet monoamine oxidase in schizophrenia. Archives of General Psychiatry, 33, 1370–3.
Owen, F., Cookson, I. B. & Ridges, A. P. (1974) Monoamine oxidase activity—a genetic marker for schizophrenia? Acta Geneticae Medicae et Gemellologiae, 23, 371–6.
Robinson, D. S., Lovenberg, W., Keiser, H. & Sjoerdoma, A. (1968) Effects of drugs on human blood platelets and plasma amine oxidase in vitro and in vivo. Biochemical Pharmacology, 17, 109–19.
Sandler, M. & Youdim, M. B. H. (1972) Multiple forms of monoamine oxidase functional significance. Pharmacological Reviews, 24, 331–49.
Schildkraut, J. J., Herzog, J. M., Orsulak, P. J., Edelman, S. E., Shein, H. M. & Frazier, S. H. (1976) Reduced platelet monoamine oxidase activity in a subgroup of schizophrenic patients. American Journal of Psychiatry, 133, 438–40.
Schildkraut, J. J., Orsulak, P. J., Schalzberg, A. F., Cole, J. O., Gudeman, J. E. & Rohde, W. A. (1978) Elevated platelet monoamine oxidase activity in schizophrenia—related depressive disorders. American Journal of Psychiatry, 135, 110–12.
Schneider, K., (1959) Clinical Psychopathology. New York: Grune & Stratton.
Shaskan, E. G. & Becker, R. E. (1975) Platelet monoamine oxidase in schizophrenics. Nature, 253, 659–60.
Tipton, K. F. & Youdim, M. B. H. (1976) Assay of monoamine oxidase. CIBA Foundation Symposium, 39, 393403.
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press.
Youdim, M. B. H. (1976) Preparation of human platelets. CIBA Foundation Symposium, 39, 405–6.
Youdim, M. B. H., Woods, H. F., Grahame-Smith, D. G., Mitchell, B. & Callender, S. (1975) Human platelet monoamine oxidase activity in iron-deficiency anaemia. Clinical Science and Molecular Medicine, 48, 289–95.
Young, D. S. & Hicks, J. M. (1965) Method for the automatic determination of serum iron. Journal of Clinical Pathology, 18, 98102.

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Monoamine Oxidase (Mao) of Platelets, Plasma, Lymphocytes and Granulocytes in Schizophrenia

  • Peter A. Bond (a1), Richard L. Cundall (a1) and Ian R. H. Falloon (a1)
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