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Intermittent Medication, Coping and Psychotherapy Interactions in Relapse Prevention and Course Modification

  • Peter Müller (a1), Borwin Bandelow (a1), Wolfgang Gaebel (a2), Wolfgang Köpcke (a2), Michael Linden (a2), Franz Müller-Spahn (a1), Adolf Pietzcker (a2), Elke Schaefer (a1) and Joachim Tegeler (a3)...

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There has been increasing interest in intermittent medication as a viable alternative to continuous neuroleptic treatment for chronic schizophrenic patients. Considerations supporting the plausibility of a targeted-medication approach include the fact that long-term medication involves certain risks, and that neither favourable outcome in the long-term nor risk of relapse are necessarily dependent on the continuous administration of neuroleptic drugs. An intermittent-targeted administration strategy was developed by Herz et al (1989) in an attempt to abort relapses at an early stage and to stabilise or to improve the course taken by illness.

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Aitken, R. C. B. (1969) Measurement of feeling using visual analogue scales. Proceedings of the Royal Society of Medicine, 62, 989993.
Böker, W., Brenner, H. D. & Alberti, L. (1982) Über eine Untersuchung subjektiver Neuroleptikawirkung bei Schizophrenen. In Psychopharmakotherapie (ed. Haase, H. J.), pp. 87108. Erlangen: Perimed.
Böker, W., Brenner, H. D. & Alberti, L. (1983) Selbstheilungsversuche Schizophrener. Nervenarzt, 54, 578589.
Böker, W., Brenner, H. D. & Würgler, S. (1989) Vulnerabilitätsverbundene Defizienzen, Psychopathologie und Bewältigungsverhalten bei Schizophrenen und deren Angehörigen. In Schizophrenie als Systemische Störung (eds W. Böker & H. D. Brenner), pp. 283299. Bern: Huber.
Brenner, H. D. (1989) Die Therapie basaler psychischer Dysfunktionen aus systemischer Sicht. In Schizophrenie als Systemische Störung (eds W. Böker & H. D. Brenner), pp. 170188. Bern: Huber.
Brenner, H. D., Böker, W. & Rui, C. (1986) Subjektive Neuroleptikawirkung bei Schizophrenen und ihre Bedeutung für die Therapie. In Seiteneffekte und Störwirkungen der Psychopharmaka (eds H. Hinterhuber, H. Schubert & F. Kulhanek), pp. 97107. Stuttgart: Schattauer.
Brenner, H. D., Böker, W., Müller, J., et al (1987) On autoprotective efforts of schizophrenics, neurotics and controls. Acta Psychiatrica Scandinavica, 75, 405414.
Carpenter, W. T., Heinrichs, D. W. & Hanlon, T. E. (1987) A comparative trial of pharmacologic strategies in schizophrenia. American Journal of Psychiatry, 144, 14661470.
Carpenter, W. T., Heinrichs, D. W. & Hanlon, T. E., et al (1990) Continuous v. targeted medication in schizophrenic outpatients: outcome results. American Journal of Psychiatry, 147, 11381142.
Heinrich, K. & Tegeler, J. (1983) Dyskognitive, apathische und extrapyramidale Syndrome bei Langzeit-Neurolepsie. In Therapie mit Neuroleptika (eds H. Hippius & H. E. Klein), pp. 194202. Erlangen: Perimed.
Herz, M. I., Glazer, W., Mirza, M., et al (1989) Die Behandlung prodromaler Episoden zur Prävention von Rückfällen in der Schizophrenic In Schizophrenie als Systemische Stöning (eds W. Böker & H. D. Brenner), pp. 270282. Bern: Huber.
Herz, M. I., Glazer, W., Mostert, M. A., et al (1991) Intermittent vs maintenance medication in schizophrenia. Archives of General Psychiatry, 48, 333339.
Jerusalem, M. (1990) Persönliche Ressourcen, Vulnerability und Stresserleben. Göttigen: Psychologic
Jolley, A. G., Hirsch, S. R., McRink, A., et al (1989) Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical outcome at one year. British Medical Journal, 298, 985990.
Jolley, A. G., Hirsch, S. R., Morrison, E., et al (1990) Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical and social outcome at two years. British Medical Journal, 301, 837842.
Linden, M., Nather, J. & Wilms, H. U. (1988) Zur Definition, Bedeutung und Messung der Krankheitskonzepte von Patienten. Die Krankheitskonzeptskala (KK-Skala) für schizophrene Patienten. Fortschritte der Neurologie und Psychiatrie, 56, 3543.
Müller, P. (1983) Was sollen wir Schizophrenen raten: Medikamentöse Langzeitprophylaxe oder Intervallbehandlung? Nervenarzt, 54, 477485.
Müller, P. (1990) Neuroleptikainduzierte Depressionen – Tatsache oder Fiktion? In Leitlinien neuroleptischer Therapie (ed. Heinrich, K.), pp. 239248. Berlin: Springer.
Müller, P. (1991) Psychotherapie bei schizophrenen Psychosen – historische Entwicklung, Effizienz und gegenwärtig Anerkanntes. Fortschritte in Neurologie und Psychiatrie, 59, 277285.
Pietzcker, A., Gaebel, W., Köpcke, W., et al (1986) A German multicenter study on the neuroleptic long-term therapy of schizophrenic patients. Preliminary report. Pharmacopsychiatry, 19, 161166.
Pietzcker, A., Gaebel, W., Köpcke, W., et al (1992) Intermittent vs maintenance neuroleptic long-term treatment in schizophrenia – two year results of a German multicenter study (unpublished).
Post, R. M., Ruvinow, D. R. & Ballenger, J. C. (1986) Conditioning and sensitisation in the longitudinal course of affective illness. British Journal of Psychiatry, 149, 191201.
Süllwold, L. (1982) Zum Einfluss von Sekundärreaktionen auf die Langzeitentwicklung schizophrener Psychosen. In Biologische Psychiatrie (Ed. H. Beckmann). Stuttgart: Thieme.
Von Zerssen, D. & V. Koeller, D. M. (1976) Paranoid-Depressivitats-Skala. Weinheim: Beltz.

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Intermittent Medication, Coping and Psychotherapy Interactions in Relapse Prevention and Course Modification

  • Peter Müller (a1), Borwin Bandelow (a1), Wolfgang Gaebel (a2), Wolfgang Köpcke (a2), Michael Linden (a2), Franz Müller-Spahn (a1), Adolf Pietzcker (a2), Elke Schaefer (a1) and Joachim Tegeler (a3)...
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