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        Impact of screening for risk of suicide: randomised controlled trial
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        Impact of screening for risk of suicide: randomised controlled trial
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Abstract

Background

Concerns have been expressed about the impact that screening for risk of suicide may have on a person's mental health.

Aims

To examine whether screening for suicidal ideation among people who attend primary care services and have signs of depression increases the short-term incidence of feeling that life is not worth living.

Method

In a multicentre, single-blind, randomised controlled trial, 443 patients in four general practices were randomised to screening for suicidal ideation or control questions on health and lifestyle (trial registration: ISRCTN84692657). The primary outcome was thinking that life is not worth living measured 10–14 days after randomisation. Secondary outcome measures comprised other aspects of suicidal ideation and behaviour.

Results

A total of 443 participants were randomised to early (n = 230) or delayed screening (n = 213). Their mean age was 48.5 years (s.d. = 18.4, range 16–92) and 137 (30.9%) were male. The adjusted odds of experiencing thoughts that life was not worth living at follow-up among those randomised to early compared with delayed screening was 0.88 (95% CI 0.66–1.18). Differences in secondary outcomes between the two groups were not seen. Among those randomised to early screening, 37 people (22.3%) reported thinking about taking their life at baseline and 24 (14.6%) that they had this thought 2 weeks later.

Conclusions

Screening for suicidal ideation in primary care among people who have signs of depression does not appear to induce feelings that life is not worth living.

Footnotes

The study was funded by an educational grant from Imperial College London and supported by St Mary's Paddington Charitable Trust.

Declaration of interest

None.

Suicide is a major cause of premature mortality, which results in over 1 million deaths worldwide per year. 1 Previous research demonstrating high levels of contact with primary care in the period prior to completed suicide 24 has highlighted the role that such services might play in efforts to reduce the incidence of suicide. 5 A central component of guidelines for the assessment and treatment of depression in primary care is asking patients about suicidal ideas and intent. 6 Despite the emphasis placed on screening for risk of suicide among people with signs of depression, studies have found low levels of assessment among people treated in primary care. 79 Reasons for this include concerns about the impact on patients of being asked such questions. 8,10 In a vignettes-based study of 170 general practitioners (GPs) in Germany, 1 in 5 stated that they would not assess suicide risk among elderly patients with depression because they feared that asking such questions could ‘induce’ suicidal thoughts and behaviour. 11 A more recent survey of GPs in England revealed that a quarter believed that screening for suicidal ideation could induce a person to have thoughts of self-harm. 12 General practitioners that took part in this study stated that young people and those with personality disorder may be especially susceptible to the effects of being asked such questions.

Support for the notion that suicidal ideation can be ‘transmitted’ by exposure to this subject comes from observational studies showing clustering of suicidal behaviour on in-patient mental health units 13 and short-term increase in the incidence of suicidal behaviour following media coverage of incidents of suicide. 1416

It has been argued that before screening for health-related problems is introduced, the potential harms as well as potential benefits need to be examined. 17 The impact of screening for suicidal ideation among people with signs of depression in primary care has not been examined. An official inquiry into methods for preventing suicide in the USA concluded that, for this reason, screening for suicide risk in primary care could not be supported. 18 In the light of the uncertainty about the impact of screening for suicidal ideation in primary care, we set out to conduct a clinical trial among people who have signs of depression and are treated in this setting. Our primary aim was to find out whether being screened for suicidal ideation had a short-term impact on the extent to which patients subsequently felt that their life was not worth living.

Method

We conducted a randomised trial (trial registration: ISRCTN84692657) among people attending primary care services in north and west London. We recruited study participants from four practices where we had established links with local clinicians. The practices are all in inner-city areas that have a relatively young and ethnically diverse population. 19 The practices each serve between 7000 and 9000 local residents. Recruitment took place over a 22-month period (March 2007 to December 2008).

Study procedures

People registered with these practices who were aged over 18 were screened for depression using a two-item screening questionnaire (‘During the past month, have you often been bothered by feeling down, depressed or hopeless?’ and ‘During the past month, have you often been bothered by little interest or pleasure in doing things?’). 20

Those who responded ‘yes’ to either or both items were given written and verbal information about the study and asked to provide consent to take part. In most instances a researcher (P.B. or L.T.) asked the screening questions prior to the clinical consultation. In a minority of instances, clinical staff working in the practice used the screening questions during the clinical consultation or as part of routine health checks.

Potential participants were told that we were conducting a clinical trial that aimed to find out how people respond to being screened for ‘health and emotional problems’ – no mention was made of depression, suicidal thoughts or behaviour. Those who agreed to take part in the study and had sufficient command of English to complete the baseline interview were randomised to screening for suicidal ideation or questions on health and lifestyle. We used simple randomisation based on a central computer-generated list. All study participants were interviewed on the telephone on two occasions separated by between 10 and 14 days. During the first of these interviews, which was usually conducted by the researcher that recruited the participant (P.B. or L.T.), we repeated the two-item screening questionnaire for depression, collected basic demographic data and assessed participants’ mental health using the 12-item General Health Questionnaire (GHQ). 21 A score of three or more on this questionnaire is taken to indicate caseness. 22 In addition, participants were asked six further questions on either suicidal ideation and behaviour or health and lifestyle depending on their allocation status.

Questions on suicidal ideation and behaviour were based on those widely used in previous studies examining public mental health 2325 which have been recommended as helpful for assessing suicide risk. 26 They were: ‘In the last 2 weeks: Have you felt that life was not worth living? Have you wished that you were dead – for instance, that you would go to sleep and not wake up? Have you thought of taking your life even if you would not really do it? Have you seriously considered taking your life? Have you attempted to take your life?’ We also asked participants about exposure to suicidal behaviour among people close to them as this has been highlighted as an important factor to consider when assessing for risk of suicide. 26 We asked participants: ‘Has any member of your family or someone else you are close to attempted to harm themselves or commit suicide in the past?’ Control questions on diet and lifestyle were taken from the Preventive Nutrition Project. 27

All follow-up interviews were conducted by a different researcher who was masked to the participant's allocation status. On this occasion all participants were asked the six questions on suicidal ideation and behaviour. In response to concerns expressed by some healthcare professionals that people with personality disorder may be susceptible to negative effects of screening for suicidal ideation, 12 we used an eight-item screening tool to assess personality (the Standardised Assessment of Personality – Abbreviated Scale, SAPAS). 28 We used a cut-off point of three or more on the SAPAS to indicate ‘probable personality disorder’. Finally, we asked four questions on social support taken from the Close Persons’ Questionnaire. 29

When participants described thoughts that life was not worth living the researcher made further assessment of suicide risk, encouraged the person to make use of resources already available to them (such as discussing their feelings with healthcare staff), and provided information about helplines and other sources of help. In rare instances where participants reported suicidal plans, the researcher asked for verbal consent to contact clinical staff on their behalf. Brent Medical Ethics Committee approved the study prior to the start of data collection (06/Q048/73).

Sample size

Data from a previous population-based study of mental health in England suggests that 31% of people who have evidence of depression have thought that life was not worth living during the previous week. 25 In order to have 80% power and 5% level of significance to detect an increase in the proportion who felt their life was not worth living from 30 to 45%, we needed to recruit a sample of 326 individuals. To take account of the clustered nature of the study sample and in anticipation of 15% loss to follow-up we increased the sample size to 429 participants.

Data analysis

All analyses were based on the intention-to-treat principle using a complete case analysis. Simple descriptive statistics were used to examine differences in the characteristics of those randomised to screening for suicidal ideation or questions on health and lifestyle. Differences in primary and secondary outcomes were examined by calculating odds ratios (OR) with 95% confidence intervals (95% CI). To identify factors associated with feeling life was not worth living during the follow-up interview, we used hierarchical logistic regression. All potential confounders (both demographic variables such as age and gender and clinical factors such as mental health) and interaction terms were included in the first step. The non-significant terms were eliminated one by one until the final model was obtained. The statistical methodology used in the analysis took account of the hierarchical structure of the data: people nested within general practices. This was an important consideration since we expected people from the same service to have more in common than people from other services. This analysis was carried out by gllamm, a programme written in STATA for Windows, version 10.

Results

The trial profile is shown inFig. 1. In total, 443 people were recruited. Their mean age was 48.5 years (s.d. = 18.4, range 16–92), 137 (30.9%) were male and 191 (43.1%) participants were married or in long-term relationships. Of the 421 that provided information about employment status, 201 (47.7%) were working or in training, 134 (31.87%) were unemployed and 86 (20.4%) were retired. All participants scored at least one out of two on the two depression screening questions, with 255 (57.6%) scoring positively on both. Mean score on the GHQ was 5.5 (s.d. = 3.6), with 278 (62.8%) meeting threshold for psychiatric caseness. Overall, 213 participants were randomised to screening for suicidal ideation and 230 to control questions. There were no deviations from random allocation, and data on one person (aged 16) who was erroneously randomised were included in the analysis. Baseline characteristics of those randomised to each arm of the trial are presented inTable 1.

Table 1 Baseline characteristics of 443 participants randomised to screening for suicidal ideation or questions on health and lifestyle

Characteristic Screening for suicidal ideation n = 230 Questions on health and lifestyle n = 213 Difference in means or proportions (95% CI)
Age, years: mean (s.d.) 48.5 (18.4) 48.4 (18.4) 0.07 (–3.5 to 3.4)
Women, n (%) 157 (69.2) 149 (70.0) – 0.8 (–9.3 to 7.7)
Not married, n (%) 125 (54.3) 127 (59.6) – 5.3 (–14.3 to 3.9)
Completed higher education, n (%) 70 (31.8) 76 (37.1) 5.3 (–3.6 to 14.2)
Employment,a n (%)
     Employed or in education 101 (47.2) 100 (48.3) – 1.1 (–110.6 to 8.4)
     Unemployed 67 (31.3) 67 (32.4) – 1.1 (–9.9 to 7.8)
     Retired 46 (21.5) 40 (19.3) 2.2 (–5.5 to 9.8)
GHQ score, mean (s.d.) 5.3 (3.7) 5.8 (3.6) 0.6 (–1.2 to 1.3)

Follow-up data were obtained on the primary outcome measure for 351 (79.2%) participants. Characteristics of those who were and were not followed up at 2 weeks are presented inTable 2. Demographic characterises and mental health of those who were and were not followed up appear to be similar.

Table 2 Baseline characteristics of participants who did and did not provide follow-up data on primary outcome measure

Characteristic Followed up n = 351 Not followed up n = 92 Difference in means or proportions (95% CI)
Age, years: mean (s.d.) 49.2 (18.6) 45.4 (17.2) 3.9 (–0.5 to 8.2)
Women, n (%) 245 (69.8) 61 (68.5) 1.3 (–8.8 to 12.5)
Not married, n (%) 197 (56.1) 55 (59.8) – 3.7 (–14.4 to 7.8)
Completed higher education, n (%) 112 (32.9) 34 (40.0) – 7.1 (–18.7 to 4.0)
Employment, n (%)
     Employed or in education 151 (44.7) 50 (60.2) – 15.6 (–26.7 to –3.5)
     Unemployed 116 (34.3) 18 (18.1) 12.6 (1.5 to 21.8)
     Retired 71 (21.0) 15 (18.1) 2.9 (–7.4 to 11.2)
GHQ score, mean (s.d.) 5.5 (3.7) 5.5 (3.6) 0.01 (–0.8 to 0.9)

At the 2-week follow-up interview, 46 (28.0%) of those randomised to screening for suicidal ideation and 45 (24.1%) of those randomised to control questions reported feeling that their life was not worth living (OR = 1.23, 95% CI 0.76–1.98). Of those randomised to questions on suicidal ideation, 38 (23.2%) reported wishing they were dead compared with 43 (22.9%) of those randomised to questions on health and lifestyle (OR = 1.01, 95% CI 0.61–1.66). Of those screened for suicidal ideation, 24 (14.7%) reported having thought of taking their life compared with 21 (11.3%) asked questions on health and lifestyle (OR = 1.36, 95% CI 0.72–2.54). One person who was randomised to control questions reported having attempted to take their life at follow-up; no one among those randomised to screening for suicidal ideation reported having done so.

Fig. 1 Trial profile.

Among those who were randomised to baseline screening for suicidal ideation and followed up, 37 (22.5%) of 164 people reported thinking about taking their life during the previous 2 weeks. Of 164 participants, 24 (14.6%) reported thinking about taking their life 2 weeks later, and 5 (3.9%) of 129 people who denied thinking about ending their life at baseline reported thinking so during the 2 weeks after screening. In contrast, 17 (45.9%) of the 37 people who had thought about ending their life at baseline denied having this thought at follow-up.

Factors associated with feeling life was not worth living adjusted for clustering at the level of general practice are presented inTable 3. The odds of feeling that life was not worth living among those screened for suicidal ideation compared with those asked questions on health and lifestyle was 0.88 (95% CI 0.66–1.18). In this model, the thought that life was not worth living at follow-up varied between the four general practices and was strongly associated with baseline mental health and the presence of probable personality disorder. Associations between the primary outcome with age and level of social support were not found. An interaction between being randomised to screening for suicidal ideation and employment status was found, suggesting that among those who were screened at baseline, suicidal ideation at follow-up was less likely among those who were retired compared with those who were unemployed. Interactions between personality status and age and the impact of being screened for suicidal ideation during the baseline interview were not found.

Table 3 Factors associated with feeling life is not worth living among 351 study participants who completed follow-up interviews

Factor Odds ratio Standard error 95% CI P
Screened for suicidal ideation at baseline 0.88 0.13 0.66–1.18 0.38
General practice
     Practice 1 Reference
     Practice 2 0.75 0.08 0.61–0.93 0.01
     Practice 3 1.67 0.26 1.22–2.27 0.01
     Practice 4 0.82 0.07 0.69–0.97 0.02
Psychiatric caseness according to GHQ 1.28 0.04 1.20–1.37 <0.001
Probable personality disorder 2.55 0.56 1.66–3.92 <0.001
Employment status
     Unemployed reference
     Employed 0.13 0.07 0.05–0.37 <0.001
     Retired 0.95 0.45 0.38–2.38 0.91
Living alone 0.51 0.22 0.22–1.19 0.12
Interactions
     Suicide screening × employed 4.72 4.40 0.76–29.30 0.10
     Suicide screening × retired 0.42 0.04 0.35–0.52 <0.001
     Living alone × employed 6.19 6.30 0.84–45.48 0.07
     Living alone × unemployed 7.33 8.45 0.76–70.22 0.08

Discussion

Our findings confirm that many people who have signs of depression and are treated in primary care experience suicidal ideation. More than 1 in 8 people who took part in the study reported that they had thought of taking their life during the previous 2 weeks, although fewer than 1 in 20 reported having given serious consideration to ending their life. We found no evidence to support the view that screening for suicidal ideation among people in primary care leads to an increase in feelings that life is not worth living.

Strengths and limitations

The main strengths of the study were that it was randomised and that researchers collecting follow-up data were masked to allocation status. By focusing on people who had signs of depression, we included those patients for whom screening for suicidal ideation has been recommended. 6 We focused our collection of follow-up data on the first 2 weeks after screening because data from observational studies suggest that if increases in suicidal ideation were to be found it would be within this period. 14

There are four main limitations associated with the study design. First, although we achieved the study sample we aimed to recruit and this was sufficient to detect clinically important differences in thoughts that life was not worth living, the power of the study was insufficient to explore differences in subgroups of patients, or to detect differences in other aspects of suicidal ideation or behaviour. With an incidence of 3 per 1000 in the 2-week period that we studied, we would have needed to have randomised over a million people to have had sufficient power to examine differences in the incidence of self-harm during this period. However, feelings that life is not worth living provide a sensitive (if not specific) indication of those at increased risk of suicidal behaviour 24 and we believe that this outcome provided a sensitive measure of the potential impact of screening on the emotional health of study participants.

Second, we could not collect baseline data on levels of suicidal ideation or behaviour among those randomised to questions on health and lifestyle, as to do so would have undermined the central aim of the study. As a result, we do not know whether levels of suicidal ideation differed between study groups at baseline. However, we were able to assess general mental health, a factor which was strongly associated with suicidal ideation, and we believe that the adjusted odds ratios we have presented therefore provide a more accurate estimate of the true relationship between screening and future suicidal ideation.

Third, study participants were all recruited from relatively deprived inner-city practices. Almost 40% of adults of working age that took part in the study were unemployed. Although we have no reason to believe that screening for suicidal ideation would be associated with different outcomes among people living in less deprived areas, we cannot be certain of this.

Finally, the method we used to screen for suicidal ideation in the study differed from the approach that would normally be taken in clinical practice. Interviews with participants were conducted on the telephone after their visit to the GP rather than face to face as part of a clinical consultation. Although the external validity of the study would have been greater if participants had been asked about suicidal thoughts during the session with the doctor, GPs told us that it would be impractical for them to randomise patients during the clinical consultation.

Clinical implications

This is the first time that the impact of screening for suicidal ideation has been examined experimentally among adults. However, a previous attempt was made to examine the impact of screening school-aged children for risk of suicide using a self-completed questionnaire. 30 Two days after completing the survey, the mental health of those that had been asked questions about suicidal thoughts was no worse than that of children who had not been asked these questions. As with our study, confidence limits around the odds ratio for suicidal ideation were broad (OR = 1.2, 95% CI 0.72–2.00), but sufficient for the authors to conclude that screening did not increase the likelihood of such thoughts. 30

Although our findings have implications primarily for those working in primary care settings, we believe that in the absence of evidence on the impact of screening for suicidal ideation in general hospital settings, these data have wider implications. Researchers investigating the epidemiology of suicidal behaviour face a variety of ethical challenges, 31 and concerns about the impact of assessing suicidal ideation in research projects have been raised in the past. 32 Ethics committees have expressed concerns about the impact of research participants being asked such questions, and these findings may help reassure those reviewing proposals for new studies that asking questions about risk of suicide does not appear to have a short-term detrimental effect on people's mental health.

Among those who were randomised to screening for suicidal ideation, we found that very few people who did not have thoughts of ending their life at baseline reported having these thoughts at follow-up. In contrast almost half of those who reported thinking of ending their life at baseline denied having this thought during the following 2 weeks. These findings support those of a population-based study by Gunnell and colleagues who found that most people who experience thoughts of ending their life no longer do so 18 months later. 33 They also provide support for the view that ‘watchful waiting’ of those with suicidal ideation is appropriate in primary care, in the absence of firmer evidence of risk of suicide such as a suicide plan. 6

Although these data provide evidence that screening for suicidal ideation does not have an impact on the likelihood of subsequent suicidal ideation, they do not provide information about how patients feel about being asked such questions. For some healthcare practitioners and patients the topic of suicide remains a sensitive one 10,12 and such enquiry needs to be handled in a sensitive manner. Our data suggest that when these questions are asked in such a manner they do not appear to increase the likelihood of people starting to think their life may not be worth living.

This study did not examined whether screening for suicidal ideation in primary care leads to improved patient outcomes. Previous research examining the impact of a primary care-based intervention following self-harm found no evidence of patient benefit. 34 Further research is required to examine the process and outcomes of screening for suicide risk in primary care to establish the impact of current guidelines which advocate this practice.

In summary, screening for risk of suicide does not appear to increase the likelihood of a person having thoughts that life is not worth living. Primary care workers should have the confidence to screen for suicide risk among people with signs of depression.

Funding

The study was funded by an educational grant from Imperial College London and supported by St Mary's Paddington Charitable Trust.

Acknowledgements

We thank Christine Lyons, Elena Borreani and Melissa Patel for their help with data collection.

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