Skip to main content Accessibility help
×
Home

Hypofrontality in men with first-episode psychosis

  • V. Molina (a1), J. Sanz (a2), S. Reig (a3), R. Martínez (a3), F. Sarramea (a4), R. Luque (a4), C. Benito (a5), J. D. Gispert (a6), J. Pascau (a6) and M. Desco (a6)...

Abstract

Background

Decreased metabolic activity in the prefrontal cortex during cognitive activation is a recurrent finding and a likely functional marker of schizophrenia.

Aims

To investigate the occurrence of hypofrontality in patients with first-episode psychosis, with or without evolution to schizophrenia.

Method

We used fluorodeoxyglucose positron emission tomography during the performance of an attention task and magnetic resonance imaging to study the dorsolateral prefrontal region in 13 men with a first episode of psychosis. Data from patients who progressed to schizophrenia were compared with those of patients who did not meet criteria for this diagnosis after 2 years.

Results

Patients who developed schizophrenia demonstrated a significant hypofrontality in the dorsolateral prefrontal cortex in comparison with the non-schizophrenia and control groups.

Conclusions

Our results suggest that hypofrontality could be a marker of schizophrenia at the time of the first psychotic episode, in agreement with neurodevelopmental theories of schizophrenia.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Hypofrontality in men with first-episode psychosis
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Hypofrontality in men with first-episode psychosis
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Hypofrontality in men with first-episode psychosis
      Available formats
      ×

Copyright

Corresponding author

Dr V. Molina, Department of Psychiatry, Hospital Cliníco de Salamanca, Paseo de San Vicente, 58-182, 37007b Salamanca, Spain. Tel: +34 923 291383; Fax: +34 923 229158; e-mail: vmolina@usal.es

Footnotes

Hide All

Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes

References

Hide All
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.
Andreasen, N. C., Rajarethinam, R., Cizadio, T., et al (1996) Automatic atlas-based volume estimation of human brain regions from MR images. Journal of Computer Assisted Tomography, 20, 98106.
Andreasen, N. C., O'Leary, D. S., Flaum, M., et al (1997) Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients. Lancet, 349, 17301734.
Anonymous (1998) Regional cerebral blood flow in first-episode schizophrenia patients before and after antipsychotic drug treatment. Scottish Schizophrenia Research Group. Acta Psychiatrica Scandinavica, 97, 440449.
Ashburner, J. & Friston, K. J. (1997) Multimodal image coregistration and partitioning – a unified framework. Neuroimage, 6, 209217.
Bartlett, E. J., Brodie, J. D., Simkowitz, P., et al (1994) Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects. American Journal of Psychiatry, 151, 681686.
Bartlett, E. J., Brodie, J. D., Simkowitz, P., et al (1998) Effect of a haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients. American Journal of Psychiatry, 155, 337343.
Blumberg, H. P., Stern, E., Ricketts, S., et al (1999) Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. American Journal of Psychiatry, 156, 19861988.
Blumberg, H. P., Stern, E., Martinez, D., et al (2000) Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry, 48, 10451052.
Buchsbaum, M. S., Haier, R. J., Potkin, S. G., et al (1992) Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Archives of General Psychiatry, 49, 935942.
Desco, M., Pascau, J., Reig, S., et al (2001) Multimodality image quantification using Talairach grid. In Proceedings of SPIE Medical Imaging, vol. 4332, pp. 13851392. San Diego, CA: IEEE.
First, M. B., Spitzer, R. L., Gibbon, M., et al (1997) Structured Clinical Interview for DSM–IV Axis I Disorders – Clinician Version. Washington, DC: American Psychiatric Association.
Frackowiak, R. S. J., Friston, K. J., Frith, C. D., et al (1997) Human Brain Function. San Diego, CA: Academic Press.
Gur, R. E., Cowell, P., Turetsky, B. I., et al (1998) A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry, 55, 145152.
Hollingshead, A. & Frederick, R. (1953) Social stratification and psychiatric disorders. American Sociological Review, 18, 163189.
Kates, W. R., Worsofsky, I. S., Patwardhan, A., et al (1999) Automated Talairach atlas-based parcellation and measurement of cerebral lobes in children. Psychiatry Research: Neuroimaging, 91, 1130.
Kay, S. R., Opler, L. A. & Fiszbein, A. (1992) Positive and Negative Syndrome Scale (PANSS): Manual. New York: Multi-Health Systems.
Marchal, G., Rioux, P., Petit-Taboue, M. C., et al (1992) Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. Archives of Neurology, 49, 10131020.
McGuire, P. K., Quested, D. J., Spence, S. A., et al (1998) Pathophysiology of ‘positive’ thought disorder in schizophrenia. British Journal of Psychiatry, 173, 231235.
Molina, V., Reig, S., Sarramea, F., et al (2003) Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia. Psychiatry Research: Neuroimaging, 124, 153161.
Nopoulos, P., Flaum, M. & Andreasen, N. C. (1997) Sex differences in brain morphology in schizophrenia. American Journal of Psychiatry, 154, 16481654.
Pantelis, C., Velakoulis, D., McGorry, P. D., et al (2003) Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MR comparison. Lancet, 361, 281288.
Peralta, V. & Cuesta, M. J. (2004) The deficit syndrome of the psychotic illness. A clinical and nosological study. European Archives of Psychiatry and Clinical Neurosciences, 254, 165171.
Rapoport, J. L., Giedd, J. N., Blumenthal, J., et al (1999) Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Archives of General Psychiatry, 56, 649654.
Rosvold, H., Mirsky, A., Sarason, I., et al (1956) A continuous-performance test of brain damage. Journal of Consulting Psychology, 20, 343352.
Rubin, P., Holm, S., Friberg, L., et al (1991) Altered modulation of prefrontal and subcortica brain activity in newly diagnosed schizophrenia and schizophreniform disorder. A regional cerebral blood flow study. Archives of General Psychiatry, 48, 987995.
Rubinsztein, J. S., Fletcher, P. C., Rogers, R. D., et al (2001) Decision-making in mania: a PET study. Brain, 124, 25502563.
Schroeder, J., Buchsbaum, M. S., Siegel, B. V., et al (1994) Patterns of cortical activity in schizophrenia. Psychological Medicine, 24, 947955.
Shihabuddin, L., Buchsbaum, M. S., Hazlett, E. A., et al (1998) Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task. Archives of General Psychiatry, 55, 235243.
Siegel, B. V., Buchsbaum, M. S., Bunney, W. E., et al (1993) Cortical – striatal – thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. American Journal of Psychiatry, 150, 13251336.
Talairach, J. & Tournoux, P. (1988) Co-Planar Stereotaxic Atlas of the Human Brain. New Tork: Thieme.
Volz, H., Gaser, C., Häger, F., et al (1999) Decreased frontal activation in schizophrenics during stimulation with the continuous performance test – a functional magnetic resonance imaging study. European Psychiatry, 14, 1724.
Woods, R. P., Mazziotta, J. C. & Cherry, S. R. (1993) MRI – PET registration with automated algorithm. Journal of Computer Assisted Tomography, 17, 536546.

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Hypofrontality in men with first-episode psychosis

  • V. Molina (a1), J. Sanz (a2), S. Reig (a3), R. Martínez (a3), F. Sarramea (a4), R. Luque (a4), C. Benito (a5), J. D. Gispert (a6), J. Pascau (a6) and M. Desco (a6)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *