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Hereditary Agoraphobia and Obsessive-Compulsive Behaviour in Relatives of Patients with Gilles de la Tourette's Syndrome

Published online by Cambridge University Press:  02 January 2018

D. E. Comings  and
B. G. Comings
D. E. Comings*
Affiliation:
City of Hope Medical Center
B. G. Comings
Affiliation:
Private Practice
*
Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
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Extract

We present 11 pedigrees in which a propositus with Gilles de la Tourette's syndrome had first or second-degree relatives with obsessive-compulsive behaviour or agoraphobia with panic attacks, but only partially expressed the TS gene (i.e. had only motor tics or vocal tics, or neither). Of 90 females over the age of 18 presenting with TS, or with motor or vocal tics alone, nine had severe agoraphobia with panic attacks. There may be genetic subtypes of both obsessive-compulsive disorder and agoraphobia with panic attacks that are due to partial expression of the TS gene.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 2 , August 1987 , pp. 195 - 199
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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