Skip to main content Accessibility help
×
Home

Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome

  • C. M. Bonnin (a1), C. Torrent (a1), C. Arango (a2), B. L. Amann (a3), B. Solé (a1), A. González-Pinto (a4), J. M. Crespo (a5), R. Tabarés-Seisdedos (a6), M. Reinares (a1), J. L. Ayuso-Mateos (a7), M. P. García-Portilla (a8), Á. Ibañez (a9), M. Salamero (a10), E. Vieta (a10), A. Martinez-Aran (a11) and CIBERSAM Functional Remediation Group...

Abstract

Background

Few randomised clinical trials have examined the efficacy of an intervention aimed at improving psychosocial functioning in bipolar disorder.

Aims

To examine changes in psychosocial functioning in a group that has been enrolled in a functional remediation programme 1 year after baseline.

Method

This was a multicentre, randomised, rater-masked clinical trial comparing three patient groups: functional remediation, psychoeducation and treatment as usual over 1-year follow-up. The primary outcome was change in psychosocial functioning measured by means of the Functioning Assessment Short Test (FAST). Group×time effects for overall psychosocial functioning were examined using repeated-measures ANOVA (trial registration NCT01370668).

Results

There was a significant group×time interaction for overall psychosocial functioning, favouring patients in the functional remediation group (F = 3.071, d.f. = 2, P = 0.049).

Conclusions

Improvement in psychosocial functioning is maintained after 1-year follow-up in patients with bipolar disorder receiving functional remediation.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome
      Available formats
      ×

Copyright

Corresponding author

Eduard Vieta, Bipolar Disorder Program, Clinical Institute of Neuroscience, Hospital Clinic of Barcelona, Villarroel, 170. 08036 Barcelona, Spain. Email address: evieta@clinic.ub.es

Footnotes

Hide All

This study was supported by an ETES grant from the Spanish Ministry of Economy and Competitiveness (PI080180 & PI08/90825, PI08/90327, PI08/90675, PI08/90224, PI08/90654, PI08/90189, PI08/90916, PI08/90416, PI08/90094). PI11/00637, PI12/00912, integrado en el Plan Nacional de I+D+I y cofinanciado por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”, the CIBERSAM and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2014 SGR 398).

M.R. was supported by Beatriu de Pinós, Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement, de la Generalitat de Catalunya i del programa COFUND de les Accions Marie Curie del 7è Programa marc de recerca i desenvolupament tecnològic de la Unió Europea. M.R.-C. (CIBERSAM Functional Remediation Group) was supported by a Sara Borrell Health Research Fellowship from the Institute of Health Carlos III, Spanish Ministry of Economy and Competitiveness, an Alicia Koplowitz Research Grant and Alicia Koplowitz Grant for Short-Term Placements from the Alicia Koplowitz Foundation (Madrid, Spain).

Declaration of interest

None.

Footnotes

References

Hide All
1 Rosa, AR, Reinares, M, Michalak, EE, Bonnin, CM, Sole, B, Franco, C, et al. Functional impairment and disability across mood states in bipolar disorder. Value Health 2010; 13: 984–8.
2 Martino, DJ, Marengo, E, Igoa, A, Scápola, M, Ais, ED, Perinot, L, et al. Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: a prospective 1 year follow-up study. J Affect Disord 2009; 116: 3742.
3 Bonnin, CM, Martinez-Aran, A, Torrent, C, Pacchiarotti, I, Rosa, AR, France, C, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: a long-term, follow-up study. J Affect Disord 2010; 121: 156–60.
4 Martinez-Aran, A, Vieta, E, Torrent, C, Sanchez-Moreno, J, Goikolea, JM, Salamero, M, et al. Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disord 2007; 9: 103–13.
5 Tabares-Seisdedos, R, Balanza-Martinez, V, Sanchez-Moreno, J, Martinez-Aran, A, Salazar-Fraile, J, Selva-Vera, G, et al. Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. J Affect Disord 2008; 109: 286–99.
6 Lewandowski, KE, Cohen, BM, Keshavan, MS, Sperry, SH, Ongür, D. Neuropsychological functioning predicts community outcomes in affective and non-affective psychoses: a 6-month follow-up. Schizophr Res 2013; 148: 34–7.
7 Martinez-Aran, A, Torrent, C, Sole, B, Bonnin, M, Rosa, AR, Sanchez-Moreno, J, et al. Functional remediation for bipolar disorder. Clin Pract Epidemiol Ment Health 2011; 7: 112–6.
8 Bonnin, CM, Torrent, C, Vieta, E, Martínez-Arán, A. Restoring functioning in bipolar disorder: functional remediation. Harv Rev Psychiatry 2014; 22: 326–30.
9 Torrent, C, Bonnin, CM, Martinez-Aran, A, Valle, J, Amann, BL, González-Pinto, A, et al. Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 2013; 170: 852–9.
10 Rosa, AR, Sanchez-Moreno, J, Martinez-Aran, A, Salamero, M, Torrent, C, Reinares, M, et al. Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder. Clin Pract Epidemol Ment Health 2007; 3: 5.
11 Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 5662.
12 Ramos-Brieva, JA, Cordero-Villafáfila, A. Validation of the Castillian version of the Hamilton Rating Scale for Depression [in Spanish]. Actas Luso Esp Neurol Psiquiatr Cienc Afines 1986; 14: 324–34.
13 Young, RC, Biggs, JT, Ziegler, VE, Meyer, DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429–35.
14 Colom, F, Vieta, E, Martinez-Aran, A, Garcia-Garcia, M, Reinares, M, Torrent, C, et al. Spanish version of a scale for the assessment of mania: validity and reliability of the Young Mania Rating Scale [in Spanish]. Med Clin (Barc) 2002; 119: 366–71.
15 Vieta, E, Torrent, C, Martinez-Aran, A. Functional Remediation for Bipolar Disorder. Cambridge University Press, 2014.
16 Colom, F, Vieta, E, Martinez-Aran, A, Reinares, M, Goikolea, JM, Benabarre, A, et al. A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry 2003; 60: 402–7.
17 Wechsler, D. The Wechsler Adult Intelligence Scale – III (WAIS-III). Harcourt Assessment, 1997.
18 Delis, DC, Kramer, JH, Kaplan, E, Ober, BA. California Verbal Learning Test. Psychological Corporation, 1987.
19 Wechsler, D. Wechsler Memory Scale (3rd edition). Harcourt Assessment, 1997.
20 Heaton, RK. Wisconsin Card Sorting Test Manual. Psychological Assessment Resources, 1981.
21 Reitan, RM. Validity of the Trailmaking Test as a indication of organic brain damage. Percept Mot Skills 1958; 8: 271–6.
22 Conners, CK. Conners' Continous Performance Test (CPT-II). Technical Guide and Software Manual (2002 edn). Multihealth Systems, 2002.
23 Laes, JR, Sponheim, SR. Does cognition predict community function only in schizophrenia? A study of schizophrenia patients, bipolar affective disorder patients, and community control subjects. Schizophr Res 2006; 84: 121–31.
24 Deckersbach, T, Nierenberg, AA, Kessler, R, Lund, HG, Ametrano, RM, Sachs, G, et al. RESEARCH: Cognitive rehabilitation for bipolar disorder: an open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 2010; 16: 298307.
25 Demant, KM, Almer, GM, Vinberg, M, Kessing, LV, Miskowiak, KW. Effects of cognitive remediation on cognitive dysfunction in partially or fully remitted patients with bipolar disorder: study protocol for a randomized controlled trial. Trials 2013; 14: 378.
26 Bauer, MS, McBride, L, Williford, WO, Glick, H, Kinosian, B, Altshuler, L, et al. Collaborative care for bipolar disorder: part II. Impact on clinical outcome, function, and costs. Psychiatr Serv 2006; 57: 937–45.
27 Fuentes-Dura, I, Balanza-Martinez, V, Ruiz-Ruiz, JC, Martínez-Arán, A, Girón, M, Solé, B, et al. Neurocognitive training in patients with bipolar disorders: current status and perspectives. Psychother Psychosom 2012; 81: 250–2.
28 Vieta, E. The bipolar maze: a roadmap through translational psychopathology. Acta Psychiatr Scand 2014; 129: 323–7.
29 Bonnin, CM, Gonzalez-Pinto, A, Sole, B, Reinares, M, González-Ortega, I, Alberich, S, et al. Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder. J Affect Disord 2014; 160: 50–4.
30 Preiss, M, Shatil, E, Cermakova, R, Cimermanová, D, Ram, I. Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Front Hum Neurosci 2013; 7: 108.

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Functional remediation in bipolar disorder: 1-year follow-up of neurocognitive and functional outcome

  • C. M. Bonnin (a1), C. Torrent (a1), C. Arango (a2), B. L. Amann (a3), B. Solé (a1), A. González-Pinto (a4), J. M. Crespo (a5), R. Tabarés-Seisdedos (a6), M. Reinares (a1), J. L. Ayuso-Mateos (a7), M. P. García-Portilla (a8), Á. Ibañez (a9), M. Salamero (a10), E. Vieta (a10), A. Martinez-Aran (a11) and CIBERSAM Functional Remediation Group...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *