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Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population

  • Ralph E. Hoffman (a1), Scott W. Woods (a1), Keith A. Hawkins (a1), Brian Pittman (a1), Mauricio Tohen (a2), Adrian Preda (a3), Alan Breier (a2), Jill Glist (a4), Jean Addington (a5), Diana O. Perkins (a6) and Thomas H. McGlashan (a4)...

Summary

A tendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to shizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year 1 followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

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Corresponding author

Dr Ralph Hoffman, Yale – New Haven Psychiatric Hospital, 184 Liberty Street LV 108, New Haven, CT 06519, USA. Tel: +1 (203) 688 9734; fax: +1 (203) 688-9709; email: ralph.hoffman@yale.edu

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Declaration of interest

This was an investigator-initiated study supported by Eli Liily & Co. (T.HM). A.B. and M.T. are employed by Eli Lilly SWW R.E.H. T.H.M. and D.O.P. have received support from Eli Lilly previously.

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References

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McGlashan, T. H. Zipursky, R. B. Perkins, D. et al (2006) The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis: efficacy and safety results of one year of treatment and one year of no-treatment follow-up. American Journal of Psychiatry, 163 790799.
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Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population

  • Ralph E. Hoffman (a1), Scott W. Woods (a1), Keith A. Hawkins (a1), Brian Pittman (a1), Mauricio Tohen (a2), Adrian Preda (a3), Alan Breier (a2), Jill Glist (a4), Jean Addington (a5), Diana O. Perkins (a6) and Thomas H. McGlashan (a4)...
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