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Encode and a new landscape for psychiatric genetics

  • Akshay Nair (a1) and Robert Howard (a1)

Summary

Despite rigorous research into the genetics of neuropsychiatric disorders, the mechanism by which polygenic risk leads to complex clinical phenotypes remains unclear. The Encyclopedia of DNA Elements (ENCODE) project gives us new insight into gene regulation, and gene–gene and gene–environment interaction.

Better understanding of these key genomic mechanisms may provide the answers we have been searching for.

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Copyright

Corresponding author

Dr Akshay Nair, Department of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Email: akshay.nair@kcl.ac.uk.

Footnotes

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Declaration of interest

None.

Footnotes

References

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Encode and a new landscape for psychiatric genetics

  • Akshay Nair (a1) and Robert Howard (a1)

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