Adam, M. J., Lu, S., Jivan, S., et al (1997) Simplified purification and synthesis of F-18 setoperone. Journal of Labeled Compounds and Radiopharmaceuticals, 40, 258.
Anderson, G. M., Young, J. G., Cohen, D. J., et al (1981) Liquid-chromatographic determination of serotonin and tryptophan in whole blood and plasma. Clinical Chemistry, 27, 775–776.
Blackshear, M. A. & Sanders-Bush, E. (1982) Serotonin receptor sensitivity after acute and chronic treatment with mianserin. Journal of Pharmacology and Experimental Therapeutics, 221, 303–308.
Blin, J., Sette, G., Fiorelli, M., et al (1990) A method for the in vivo investigation of the serotonergic 5-HT2 receptors in the human cerebral cortex using positron emission tomography and 18F-labeled setoperone. Journal of Neurochemistry, 54, 1744–1754.
Breier, A., Su, T. P., Saunders, R., et al (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proceedings of the National Academy of Sciences USA, 94, 2569–2574.
Bremner, J. D., Innis, R. B., Salomon, R. M., et al (1997) Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Archives of General Psychiatry, 54, 364–374.
Butler, P. D., Pranzatelli, M. R. & Barkai, A. I. (1990) Regional central serotonin-2 receptor binding and phosphoinositide turnover in rats with 5,7-dihydroxytryptamine lesions. Brain Research Bulletin, 24, 125–129.
Cross, J. A. & Horton, R. W. (1988) Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5-HT2 binding site changes. British Journal of Pharmacology, 93, 331–336.
Crouzel, C., Venet, M., Irie, T., et al (1988) Labelling of a serotonergic ligand with 18F: 18F-setoperone. Journal of Labeled Compounds and Radiopharmaceuticals, 25, 403–414.
Delgado, P. L., Miller, H. L., Salomon, R. M., et al (1999) Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry, 46, 212–220.
Friston, K. J., Frith, C. D., Liddle, P. F., et al (1991) Comparing function (PET) images: the assessment of significant change. Journal of Cerebral Blood Flow and Metabolism, 11, 690–699.
Friston, K. J., Holmes, A. P., Worsley, K. J., et al (1995) Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping, 2, 189–210.
Goodnough, D. B. & Baker, G. B. (1994) 5-Hydroxytryptaimine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination. Journal of Neurochemistry, 62, 2262–2268.
Hensler, J. G. & Truett, K. A. (1998) Effect of chronic serotonin-2 receptor agonist or antagonist administration on serotonin-IA receptor sensitivity. Neuropsychopharmacology, 19, 354–364.
Hrdina, P. D. & Vu, T. B. (1993) Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study. Synapse, 14, 324–331.
Kellar, K. J. & Stockmeier, C. A. (1986) Effects of electroconvulsive shock and serotonin axon lesions on beta-adrenergic and serotonin-2 receptors in rat brain. Annals of the New York Academy of Sciences, 462, 76–90.
Klimek, V., Zak-Knapik, J. & Mackowiak, M. (1994) Effect of repeated treatment with fluoxetine and citalopram, 5-HTuptake inhibitors, on 5-HT1A and 5-HT2 receptors in the rat brain. Journal of Psychiatry and Neuroscience, 19, 63–67.
Lam, R. W., Bowering, T. A., Tam, E. M., et al (2000) Effects of rapid tryptophan depletion in patients with seasonal affective disorder in natural summer remission. Psychological Medicine, 30, 79–87.
Laruelle, M., D'Souza, C. D., Baldwin, R. M., et al (1997) Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology, 17, 162–174.
Leysen, J. E. (1990) Gaps and peculiarities in 5-HT2A receptor studies. Neuropsychopharmacology, 3, 361–369.
Leysen, J. E., Geerts, R., Gommeren, W., et al (1982) Regional distribution of serotonin-2-receptor binding sites in the brain and effects of neuronal lesions. Archives of International Pharmacodynamics, 256, 301–305.
Leysen, J. E. & Pauwels, P. J. (1990) 5-HT2A receptors, roles, and regulation. Annals of the New York Academy of Sciences, 600, 183–191.
Mason, G. A., Walker, C. H. & Little, K. Y. (1993) Effects of concurrent subchronic treatments with desmethylimipramine and propranolol on beta-adrenergic and serotonin2 receptors in rat brain. Psychopharmacology, 110, 110–114.
McNair, D. M., Lorr, D. & Droppelman, L. F. (1988) Manual for the Profile of Mood States.
San Diego, CA: Education Testing Services.
Nishizawa, S., Benkelfat, C., Young, S. N., et al (1998) Differences between males and females in rates of serotonin synthesis in human brain. Proceedings of the National Academy of Sciences USA, 94, 5308–5313.
Paul, I. A., Duncan, G. E., Powell, K. R., et al (1988) Regionally specific neural adaptation of beta adrenergic and 5-hydroxytrytpamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment. Journal of Pharmacology and Experimental Therapeutics, 246, 956–962.
Peroutka, S. J. & Snyder, S. H. (1980) Long-term antidepressant treatment decreases spiroperidollabeled serotonin receptor binding. Science, 210, 88–90.
Petit-Tabou, M.-C., Landeau, B., Barre, L., et al (1999) Parametric PET imaging of 5HT2A-receptor distribution with 18F-setoperone in the normal human neocortex. Journal of Nuclear Medicine, 40, 25–32.
Pietrzyk, U., Herholz, K., Fink, G., et al (1994) An interactive technique for three-dimensional image registration: validation for PET, SPECT, MRI, and CT brain studies. Journal of Nuclear Medicine, 35, 2011–2018.
Poline, J. B., Worsley, K. J., Evans, A. C., et al (1997) Combining spatial extent and peak intensity to test for activations in functional imaging. Neuroimage, 5, 83–96.
Spitzer, R. L., Williams, J. B. W., Gibbon, M., et al (1992) Structured Clinical Interview for DSM–III–R, Nonpatient Edition.
Washington, DC: American Psychiatric Association.
SPSS (1996) SPSS for Windows (Version 7.5).
Chicago, IL: SPSS.
Williams, J. B. W., Link, M. & Rosenthal, N. E. (1991) Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH–SAD).
New York: New York Psychiatric Institute.
Worsley, K. J. (1994) Local maxima and the expected Euler characteristic of excursion sets of Chi2, F and t fields. Advanced Applied Probability, 26, 13–42.
Yatham, L. N., Liddle, P. F., Dennie, J., et al (1999) Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment: a positron emission tomography study with fluorine 18-labeled setoperone. Archives of General Psychiatry, 56, 705–711.