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Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: Cluster randomised controlled trial

  • Richard Gray (a1), Til Wykes (a1), Melisa Edmonds (a1), Morven Leese (a1) and Kevin Gournay (a1)...

Abstract

Background

Non-compliance attenuates the efficacy of treatments for physical and mental disorders.

Aims

To assess the effectiveness of a medication management training package for community mental health nurses (CMHNs) in improving compliance and clinical outcomes in patients with schizophrenia.

Method

Pragmatic randomised controlled trial. Sixty CMHNs in geographical clusters were assigned randomly to medication management training or treatment as usual. Each CMHN identified two patients on their case-load who were assessed at baseline and again after 6 months by a research worker. The primary efficacy outcome of interest was psycho-pathology, measured using the Positive and Negative Syndrome Scale (PANSS).

Results

Nurses who had received medication management training produced a significantly greater reduction in patients' overall psychopathology compared with treatment as usual at the end of the 6-month study period (change in PANSS total scores: medication management – 16.62, treatment as usual 1.17; difference – 17.79; 95% CI – 24.12 to – 11.45; P<0.001).

Conclusions

Medication management training for CMHNs is effective in improving clinical outcomes in patients with schizophrenia.

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Copyright

Corresponding author

Dr Richard Gray, PO 30, Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. Tel: +44 (0)20 7848 0139; e-mail: R.Gray@iop.kcl.ac.uk

Footnotes

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Declaration of interest

The South London and Maudsley NHS Trust provided financial support.

Footnotes

References

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Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: Cluster randomised controlled trial

  • Richard Gray (a1), Til Wykes (a1), Melisa Edmonds (a1), Morven Leese (a1) and Kevin Gournay (a1)...
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