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A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives

  • Graham J. Naylor (a1), J. M. Donald (a2), David Le Poidevin (a3) and Andrew H. Reid (a2)

Extract

The therapeutic effect of lithium in mania was first described by Cade (1949), but the possibility that lithium could have a prophylactic action in recurrent affective disorders was not suggested until some years later (Hartigan, 1963; Baastrup, 1964). The early studies of the prophylactic action of lithium were open trials, in which both investigator and patient knew that the patient was receiving the drug. More recently, controlled double-blind studies have confirmed these early reports (Melia, 1970; Coppen et al., 1971; Cundall et al., 19712).

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A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives

  • Graham J. Naylor (a1), J. M. Donald (a2), David Le Poidevin (a3) and Andrew H. Reid (a2)

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A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives

  • Graham J. Naylor (a1), J. M. Donald (a2), David Le Poidevin (a3) and Andrew H. Reid (a2)
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