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A Comparison of the Antidepressant Action of Citalopram and Amitriptyline

  • D. M. Shaw (a1), D. R. Thomas (a1), M. H. Briscoe (a1), R. Crimmins (a1), B. Harris (a2), J. Lovett (a2), M. Raj (a3), A. T. Lloyd (a3), C. Osborne (a4), G. Hughes (a4), W. Waheed (a5), J. Davies (a5), A. B. Rolfe (a5), E. Satheesan (a5), A. Snape (a5), V. M. Evans (a5), N. Patel (a5) and M. A. Bari (a5)...

Extract

The response of patients with major depressive illness to citalopram of amitriptyline was compared in a double-blind multi-centre trial. No differences in efficacy were observed, but citalopram had less hypnotic effect and a remarkably lower profile of side-effects.

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Department of Psychological Medicine, University of Wales College of Medicine, Whitchurch Hospital, Whitchurch, Cardiff CF4 7XB

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Principal participants.

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References

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Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and prediction of ECT responses. British Journal of Psychiatry, 111, 659674.
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) (DSM-III). Washington, DC: APA.
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social & Clinical Psychology, 6, 278296.
Montgomery, S. A. & Asberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382389.
Snaith, R. P., Bridge, G. W. K. & Hamilton, M. (1976) The Leeds Scales for the self-assessment of anxiety and depression. British Journal of Psychiatry, 128, 156165.

A Comparison of the Antidepressant Action of Citalopram and Amitriptyline

  • D. M. Shaw (a1), D. R. Thomas (a1), M. H. Briscoe (a1), R. Crimmins (a1), B. Harris (a2), J. Lovett (a2), M. Raj (a3), A. T. Lloyd (a3), C. Osborne (a4), G. Hughes (a4), W. Waheed (a5), J. Davies (a5), A. B. Rolfe (a5), E. Satheesan (a5), A. Snape (a5), V. M. Evans (a5), N. Patel (a5) and M. A. Bari (a5)...

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A Comparison of the Antidepressant Action of Citalopram and Amitriptyline

  • D. M. Shaw (a1), D. R. Thomas (a1), M. H. Briscoe (a1), R. Crimmins (a1), B. Harris (a2), J. Lovett (a2), M. Raj (a3), A. T. Lloyd (a3), C. Osborne (a4), G. Hughes (a4), W. Waheed (a5), J. Davies (a5), A. B. Rolfe (a5), E. Satheesan (a5), A. Snape (a5), V. M. Evans (a5), N. Patel (a5) and M. A. Bari (a5)...
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