Skip to main content Accessibility help
×
Home

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

  • G. C. Dunbar (a1), J. B. Cohn (a2), L. F. Fabre (a3), J. P. Feighner (a4), R. R. Fieve (a5), J. Mendels (a6) and R. K. Shrivastava (a7)...

Abstract

To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with imipramine. Paroxetine had a possible earlier antidepressant effect than imipramine, and a possible earlier beneficial effect on anxiety symptoms associated with depression.

Copyright

Corresponding author

47–49 London Road, Reigate, Surrey RH2 9YF

References

Hide All
American Psychiatric Association (1960) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington DC: APA.
Cooper, S. M., Jackson, D., London, J. M., et al (1989) The psychomotor effects of paroxetine alone and in combination with haloperidol, amylobarbitone, oxazepam or alcohol. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 5355.
Covi, L., Rickels, K., Lipman, O. S., et al (1981) Effects of psychotropic agents on primary depression. Psychopharmacology Bulletin, 17, 100101.
Doogan, D. P. & Caillard, V. (1988) Sertraline: a new antidepressant. Journal of Clinical Psychiatry, 49 (suppl. 8), 4651.
Feighner, J. P. & Boyer, W. F. (1989) Paroxetine in the treatment of depression: a comparison with imipramine and placebo. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 125129.
Food and Drug Administration (1989) ‘COSTART’ Coding Symbols for Thesaurus of Adverse Reaction Terms (3rd edn). Rockville, Md: FDA.
Haddock, R. E., Johnson, A. M., Langley, P. F., et al (1989) Metabolic pathway of paroxetine in animals and man and the comparative pharmacological properties of its metabolites. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 2426.
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.
Herman, J. B., Brotman, A. W., Pollack, M. H., et al (1990) Fluoxetine-induced sexual dysfunction. Journal of Clinical Psychiatry, 51, 2527.
Johnson, A. (1989) An overview of the animal pharmacology of paroxetine. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 1420.
Kaye, C. M., Haddock, R. E., Langley, P. F., et al (1989) A review of the metabolism and pharmacokinetics of paroxetine in man. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 6075.
Marsden, C. A. (1987) Changes in human whole blood 5-HT and platelet 5-HT during treatment with paroxetine, a selective 5-HT uptake inhibitor. Journal of Psychopharmacology, 1, 244250.
Mas, M., Zahrandisk, M. A., Martino, V., et al (1985) Stimulation of spinal serotonergic receptors stimulates seminal emission and suppresses penile erectile reflexes. Brain Research, 342, 128134.
McClelland, G. R. & Raptopoulus, P. (1984) EEG and blood levels of the potential antidepressant paroxetine after a single oral dose to normal volunteers. Psychopharmacology, 83, 327329.
McClelland, G. R. & Raptopoulus, P. Jackson, D. (1989) The effect of paroxetine on the quantitative EEG. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 5052.
Montgomery, S. A. & Asberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382389.
Okuyama, S., Shimamura, H., Hashimoto, S., et al (1987) Relation between yawning behaviour and central serotonergic neuronal system in rats. Archives of Pharmacology, 335, 667672.
Raptopoulus, P., McClelland, G. R. & Jackson, D. (1989) The clinical pharmacology of paroxetine in healthy subjects. Acta Psychiatrica Scandinavica, 80 (suppl. 350), 4648.
Raskin, A., Schulterbrandt, J., Rectig, N., et al (1969) Replication of factors of psychopathology in interview, ward behaviour, and self report ratings of hospitalised depressives. Journal of Nervous and Mental Disease, 148, 8798.
Renji, L. (1986) The effect of selective 5-HT uptake inhibitors on 5-methoxy-N, N dimethyl tryptamine-induced ejaculation in the rat. British Journal of Pharmacology, 87, 639648.
Thomas, D. R., Nelson, D. R. & Johnson, A. M. (1987) Biochemical effect of the antidepressant paroxetine, a specific 5-HT (hydroxytryptamine) uptake inhibitor. Psychopharmacology, 93, 193200.

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

  • G. C. Dunbar (a1), J. B. Cohn (a2), L. F. Fabre (a3), J. P. Feighner (a4), R. R. Fieve (a5), J. Mendels (a6) and R. K. Shrivastava (a7)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

  • G. C. Dunbar (a1), J. B. Cohn (a2), L. F. Fabre (a3), J. P. Feighner (a4), R. R. Fieve (a5), J. Mendels (a6) and R. K. Shrivastava (a7)...
Submit a response

eLetters

We encountered an error trying to retrieve eLetters for this article. Please try again or contact Customer Services

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *