Skip to main content Accessibility help
×
Home

Childhood Attentional Dysfunctions Predict Social Deficits in Unaffected Adults at Risk for Schizophrenia

  • Barbara A. Cornblatt (a1), Mark F. Lenzenweger (a2), Robert H. Dworkin (a3) and L. Erlenmeyer-Kimling (a4)

Extract

Converging lines of evidence suggest that attentional dysfunctions are indicators of a biological susceptibility to some forms of schizophrenia. More specifically, following the criteria outlined by Holzman (1983), impaired attention can be considered a potential biological marker because of the: (a) well replicated association between schizophrenia and attentional dysfunctions in patients, both when in episode and in remission (Nuechterlein & Dawson, 1984); (b) evidence that attentional problems can be detected in unaffected first-degree adult relatives of schizophrenic patients (Wood & Cook, 1979; Keefe et al, 1989, Steinhauer et al, 1991) (c) reports from a number of high-risk studies that attentional deficits pre-date clinical symptoms by many years (Rutschmann et al, 1977; Nuechterlein, 1983; Cornblatt & Erlenmeyer-Kimling, 1985; Mirsky et al, 1986; Erlenmeyer-Kimling & Cornblatt, 1987b; Mirsky, 1988) and (4) preliminary results suggesting that attention per se is genetically transmitted (Cornblatt et al, 1988).

Copyright

Corresponding author

Correspondence

References

Hide All
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington DC: APA.
Bellack, A. S., Morrison, R. L., Wixted, J. T., et al (1990) An analysis of social competence in schizophrenia. British Journal of Psychiatry, 156, 809818.
Cattell, R. B. (1966) The Scree test for the number of factors. Multivariate Behavioral Research, 1, 245276.
Cornblatt, B. & Erlenmeyer-Kimling, L. (1985) Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology, 94, 470486.
Cornblatt, B., Risch, N., Faris, G., et al (1988) The Continuous Performance Test, Identical Pairs Version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research, 26, 223238.
Cornblatt, B., Winters, L. & Erlenmeyer-Kimling, L. (1989) Attentional markers of schizophrenia: evidence from the New York High-Risk Study. In Schizophrenia: Scientific Progress (eds S. C. Schulz & C. A. Tamminga), pp. 8392. New York: Oxford University Press.
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia (SADS). Archives of General Psychiatry, 35, 837844.
Erlenmeyer-Kimling, L. & Cornblatt, B. (1978) Attentional measures in a study of children at high-risk for schizophrenia. Journal of Psychiatric Research, 14, 9398.
Erlenmeyer-Kimling, L. & Cornblatt, B. (1987a) The New York high-risk project: A follow-up report. Schizophrenia Bulletin, 13, 451463.
Erlenmeyer-Kimling, L. & Cornblatt, B. (1987b) High-risk research in schizophrenia: a summary of what has been learned. Journal of Psychiatric Research, 21, 401411.
Holzman, P. S. (1983) Smooth pursuit eye movements in psychopathology. Schizophrenia Bulletin, 9, 3336.
Iacono, W. G. (1988) Eye movement abnormalities in schizophrenia and affective disorders. In Neuropsychology of Eye Movements (eds C. S. Johnston & F. J. Pirozzolo), pp. 115145. NJ: Lawrence Erlbaum Associates.
Keefe, R. S. E., Mohs, R. C., Siever, L. J., et al (1989) Relations among eye tracking, CPT and backward masking deficits in schizophrenic patients and their relatives. Biological Psychiatry, 25, 102.
Knight, R. A. (1984) Converging models of cognitive deficit in schizophrenia. In Nebraska Symposium on Motivation, 1983: Theories of Schizophrenia and Psychosis (eds W. D. Spaulding & J. K. Cole), pp. 93156. Lincoln: University of Nebraska Press.
Knight, R. A., A., R., Elliott, D. S., Roff, J. D., et al (1986) Concurrent and predictive validity of components of disordered thinking in schizophrenia. Schizophrenia Bulletin, 12, 427446.
Loranger, A. W., Susman, V. L., Oldham, J. M., et al (1987) The personality disorder examination: a preliminary report. Journal of Personality Disorders, 1, 113.
Matthysse, S. & Holzman, P. S. (1987) Genetic latent structure models: implication for research on schizophrenia. Psychological Medicine, 17, 271274.
Mirsky, A. (1988) The Israeli high-risk study. In Relatives at Risk for Mental Disorder (eds D. L. Dunner, E. S. Gershon & J. E. Barrett), pp. 279297. New York: Raven Press.
Mirsky, A., Duncan, C., Silberman, E., et al (1986) Early neuropsychological and other behavioral predictors of later psychotic disorders. In Biological Psychiatry (eds C. Shagass, G. Simpson, W. Bridger, et al), pp. 11181120. New York: Elsevier.
Morrison, R. L. & Bellack, A. S. (1987) Social functioning of schizophrenic patients: clinical and research issues. Schizophrenia Bulletin, 13, 715725.
Nuechterlein, K. H. (1983) Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology, 92, 428.
Nuechterlein, K. H. & Dawson, M. E. (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophrenia Bulletin, 10, 160203.
Rutschmann, J., Cornblatt, B. & Erlenmeyer-Kimling, L. (1977) Sustained attention in children at risk for schizophrenia. Archives of General Psych iatry, 34, 571575.
Siever, L. J. (1985) Biological markers in schizotypal personality disorder. Schizophrenia Bulletin, 11, 564575.
Spitzer, R. L. & Endicott, J. (1977) Schedule for Affective Disorders and Schizophrenia Lifetime Version (SADS-L) (3rd edn). New York: New York State Psychiatric Institute, Biometrics Unit.
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute, Biometrics Unit.
Squires-Wheeler, E., Skodol, A. E., Bassett, A., et al (1989) DSM-III-R Schizotypal personality traits in offspring of schizophrenia disorder, affective disorder, and normal control parents. Journal of Psychiatric Research, 23, 229239.
Steinhauer, S. R., Zubin, J., Condray, R., et al (1991) Electrophysiological and behavioral signs of attentional disturbance in schizophrenics and their siblings. In Schizophrenia Research: Advances in Neuropsychiatry and Psychopharmacology, Vol. 1 (eds Tamminga, C. A. & Schulz, S. C.), pp. 169178. New York: Raven Press.
Wechsler, D. (1949) The Wechsler Intelligence Scale for Children. New York: The Psychological Corporation.
Weissberg, R., Ruff, H. A. & Lawson, K. R. (1990) The usefulness of reaction time tasks in studying attention and organization of behavior in young children. Journal of Developmental & Behavioral Pediatrics, 11, 5964.
Winer, B. J. (1971) Statistical Principles in Experimental Designs (2nd edn). New York: McGraw-Hill.
Wood, R. L. & Cook, M. (1979) Attentional deficit in the siblings of schizophrenics. Psychological Medicine, 9, 465467.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Childhood Attentional Dysfunctions Predict Social Deficits in Unaffected Adults at Risk for Schizophrenia

  • Barbara A. Cornblatt (a1), Mark F. Lenzenweger (a2), Robert H. Dworkin (a3) and L. Erlenmeyer-Kimling (a4)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *