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Can Computerised Tomography be Used to Predict Early Treatment Response in Schizophrenia?

Published online by Cambridge University Press:  06 August 2018

J. Schröder ,
F. J. Geider  and
H. Sauer
J. Schröder*
Affiliation:
Department of Psychiatry
F. J. Geider
Affiliation:
Department of Psychiatry
H. Sauer
Affiliation:
Institute of Psychology; University of Heidelberg
*
∗Department of Psychiatry, University of Heidelberg, Voss Str. 4, D-69115 Heidelberg, Germany
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Extract

The relationship between early treatment response and CT variables was investigated in 50 consecutively admitted patients with DSM-III schizophrenia. Treatment response was defined as the absolute BPRS improvement during patients' hospital stay and was found to be significantly correlated (P<0.05) with the frontal horn ratio (r = −0.36), ventricular ratio (r = −0.32), width of the third ventricle (r= −0.37), width of the frontal interhemispheric fissure (r = −0.33), and average width of the three largest cortical sulci (r = −0.46). According to the results of multiple regression analysis, 35% of the variance in the treatment response was accounted for by the average width of the three largest cortical sulci, the ventricular ratio and the frontal horn ratio. Thus, cerebral abnormalities associated with poor treatment response do not seem to be limited to one particular morphological site, but involve different brain regions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S21: Prediction in Psychopharmacology , September 1993 , pp. 13 - 15
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III). Washington, DC: APA.Google Scholar
Barr, A. N., Heinze, W. J., Dobben, C. D., et al (1978) Bicaudate index in computerized tomography of Huntington disease and cerebral atrophy. Neurology, 28, 1196–1200.CrossRefGoogle ScholarPubMed
Baumann, U., Fahnrich, E., Stieglitz, R.-D., et al (1990) Probleme der Veränderungsmessung in Psychiatry und klinischer Psychologie. in Veränderungsmessung in Psychiatry und klinischer Psychologie (eds U. Baumann, E. Fähnrich, R.-D. Stieglitz, et at). München: Profil.Google Scholar
Bogerts, B., Falkai, P., Klieser, E., et al (1992) Can CT and MRT predict the early treatment response of schizophrenia? Pharmacopsychiatry, 25, 80.Google Scholar
Buchsbaum, M. S. (1990) The frontal lobes, basal ganglia, schizophrenia. Schizophrenia Bulletin, 16, 379–389.CrossRefGoogle ScholarPubMed
Davis, J. M. (1974) Dose equivalence of the antipsychotic drugs. Journal of Psychiatric Research, 11, 65–69.CrossRefGoogle ScholarPubMed
Kane, J., Honigfeld, G., Singer, J., et al (1988) Clozapine for the treatment-resistant schizophrenic. Archives of General Psychiatry, 45, 789–796.CrossRefGoogle ScholarPubMed
Kolakowska, T., Williams, A. O., Ardern, M., et al (1985) Schizophrenia with good and poor outcome - I. Early clinical features, response to neuroleptics and signs of organic dysfunction. British Journal of Psychiatry, 146, 229–246.CrossRefGoogle ScholarPubMed
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry, 160, 179–186.CrossRefGoogle ScholarPubMed
Naber, D., Leppig, M., Grohmann, R., et al (1989) Efficacy and adverse effects of clozapine in the treatment of schizophrenia and tardive dyskinesia - a retrospective study of 387 patients. Psychopharmacology, 99, 73–76.CrossRefGoogle ScholarPubMed
Overall, J. E. & Gorham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
SAS Institute (1985) SAS User's Guide: Basics, Statistics (5th edn). Raleigh: SAS Institute.Google Scholar
Schröder, J., Geider, F. J., Binkert, M., et al (1992) Subsyndromes in chronic schizophrenia: do their psychopathological characteristics correspond to cerebral alterations? Psychiatry Research, 42, 209–220.CrossRefGoogle ScholarPubMed
Shelton, R. C. & Weinberger, D. R. (1987) Brain morphology in schizophrenia. In Psychopharmacology: The Third Generation of Progress (ed. Meltzer, H. Y.), pp. 773–781. New York: Raven Press.Google Scholar
Vogel, H. (1986) Masse und Normwerte in der Computertomographie. Landsberg/Lech: Ecomed Verlagsgesellschaft.Google Scholar
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