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Assessment of Familial Risks in the Functional Psychoses and their Application in Genetic Counselling

Published online by Cambridge University Press:  29 January 2018

D. W. K. Kay*
Affiliation:
The University of Tasmania, Royal Hobart Hospital, Hobart, Tasmania 7000, Australia

Extract

Now that the evidence for genetic factors in the major psychoses is very strong but still essentially circumstantial (what is transmitted is unknown), there is a danger that myths about the nonexistence of mental illness may be replaced by equally misleading myths about its inheritance. The need for genetic counselling is therefore likely to increase (counselling is advice given as a result of consultation). Admittedly, the literature on counselling in mental illness is scanty, the author's own experience slight, and the public demand small. Reed (1972) stated that less than 1 per cent of the 3,000 cases seen at the Dight Institute over 20 years were concerned with schizophrenia. Nevertheless, it is probable that much unrequested and ill-informed advice is being given.

Type
Review Article
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Abe, K. (1966) Susceptibility to psychoses and precipitating factors: a study of families with two or more psychotic members. Psychiatrie et Neurologie, 151, 276–90.Google Scholar
Angst, J. (1966) Zur aetiological und Nosologie endogener depressiver Psychosen. Berlin Springer.CrossRefGoogle Scholar
Bertelsen, A., Harvold, B. & Hauge, M. (1977) A Danish twin study of manic-depressive disorders. British Journal of Psychiatry, 130, 330.Google Scholar
Bleuler, M. (1974) The offspring of schizophrenics. Schizophrenia Bulletin, 8, 93107.CrossRefGoogle Scholar
Brown, G. W., Sklair, F., Harris, T. O. & Birley, J. L. T. (1973) Life events and psychiatric disorders, Part I: Some methodological issues. Psychological Medicine, 3, 74.CrossRefGoogle Scholar
Cadoret, R. J., Winokur, G. & Clayton, P. J. (1970) Family history studies: VII. Manic-depressive disease versus depressive disease. British Journal of Psychiatry, 116, 625.Google Scholar
Cadoret, R. J., Fowler, R. C., McCabe, M. S. & Winokur, G. (1974) Evidence for heterogeneity in a group of good-prognosis schizophrenics. Comprehensive Psychiatry, 15, 443.Google Scholar
Cadoret, R. J. (1976) The genetics of affective disorder and genetic counselling. Social Biology, 23, 116.Google Scholar
Carter, C., Evans, K., Fraser-Roberts, J. A. & Buck, A. (1971) Genetic clinic: a follow-up. Lancet, i, 281–5.Google Scholar
Cooper, A. F., Curry, A. R., Kay, D. W. K., Garside, R. F. & Roth, M. (1974) Hearing loss in paranoid and affective psychoses in the elderly. Lancet, ii, 851–60.Google Scholar
Crowe, R. R. (1975) An adoptive study of psychopathy: preliminary results from arrest records and psychiatric and hospital records. In Genetic Research in Psychiatry (eds Fieve, R. R. et al) John Hopkins.Google Scholar
Davison, K. & Bagley, C. R. (1969) Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry. British Journal of Psychiatry. Special Publication No. 4, 113–84.Google Scholar
Donner, D. L. & Fieve, R. R. (1975) Psychiatric illness in fathers of men with bipolar primary affective disorder. Archives of General Psychiatry, 32, 1134.Google Scholar
Donner, D. L., Fleiss, J. L., Addonizio, G. & Fieve, R. R. (1976) Assortative mating in primary affective disorder. Biological Psychiatry, 11, 43.Google Scholar
Essen-Möller, E. (1977) Evidence for polygenic inheritance in schizophrenia? Acta Psychiatrica Scandinavica, 55, 202.Google Scholar
Feighner, J. P., Robin, E., Guze, S. B., Woodruff, R. A. Jr., Winokur, A. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57.Google Scholar
Feldman, M. W. & Lewontin, R. C. (1975) The heritability hang-up. Science, 190, 1163.Google Scholar
Fischer, M. (1973) Genetic and environmental factors in schizophrenia. Acta Psychiatrica Scandinavica Supplement 238.Google Scholar
Fowler, R. C., Tsuang, M. T. & Cadoret, R. J. (1975) A clinical and family study of paranoid and non-paranoid schizophrenics. British Journal of Psychiatry, 124, 346–59.Google Scholar
Fowler, R. C., Tsuang, M. T. (1975) Spouses of schizophrenics: a blind comparative study. Comprehensive Psychiatry, 16:4, 339.Google Scholar
Fowler, R. C., Tsuang, M. T. & Cadoret, R. J. (1977) Psychiatric illness in the offspring of schizophrenics. Comprehensive Psychiatry, 18:2, 127.Google Scholar
Garmezy, N. (1974) Children at risk: the search for the antecedents of schizoprenia. Part I. Conceptual models and research methods. Schizophrenia Bulletin, 8, 1490.Google Scholar
Gershon, E. S., Dunner, D. L., Sturt, L. & Goodwin, F. K. (1973) Assortative mating in the affective disorders. Biological Psychiatry, 7, 6374.Google Scholar
Gershon, E. S. & Bunney, W. E. (1976) The question of X-linkage in bipolar manic-depressive illness. Journal of Psychiatric Research, 13, 99.Google Scholar
Gershon, E. S., Mark, A., Cohen, N., Belison, N., Baron, M. & Knobe, K. (1975a) Transmitted factors in the morbid risk of affective disorders: a controlled study. Journal of Psychiatric Research, 12, 283.Google Scholar
Gershon, E. S., Baron, M. & Leckman, J. F. (1975b) Genetic models of the transmission of affective disorders. Journal of Psychiatric Research, 12, 301.Google Scholar
Gittleson, N. L. (1966) Depressive psychosis in the obsessional neurotic. British Journal of Psychiatry, 112, 883–7Google ScholarPubMed
Goetzl, U., Green, R., Whybrow, P. & Jackson, R. (1974) X-linkage revisited. Archives of General Psychiatry, 31, 665.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Shields, J. (1976) A critical review of recent adoption, twin and family studies of schizophrenia: behavioural genetics perspectives. Schizophrenia Bulletin, 2, 360.Google Scholar
Gottesman, I. I. & Shields, J. (1972) Schizophrenia and Genetics. London: Academic Press.Google Scholar
Hays, P. (1976) Etiological factors in manic-depressive psychoses. Archives of General Psychiatry, 33, 1187.CrossRefGoogle ScholarPubMed
Heston, L. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry, 112, 819–25.Google Scholar
Helzer, J. E. & Winokur, G. (1974) A family interview study of male manic-depressive. Archives of General Psychiatry, 31, 73.Google Scholar
Hopkinson, G. & Ley, F. (1969) A genetic study of affective disorder. British Journal of Psychiatry, 115, 9172–2.Google Scholar
James, J. W. (1971) Frequency in relatives for an all-or-none trait. Annals of Human Genetics, 35, 47.CrossRefGoogle ScholarPubMed
James, M. M. & Chapman, C. J. (1975) A genetic study of bipolar affective disorder. British Journal of Psychiatry, 126, 449.Google Scholar
Kallmann, F. J. (1956) Psychiatric aspects of genetic counselling. American Journal of Human Genetics, 8, 97101.Google Scholar
Kay, D. W. K. (1963) Late paraphrenia and its bearing on the aetiology of schizophrenia. Acta Psychiatrica Scandinavica, 39, 159–69.Google Scholar
Kay, D. W. K., Roth, M., Atkinson, M. W., Stephens, D. A. & Garside, R. F. (1976a) Genetic hypotheses and environmental factors in the light of psychiatric morbidity in the families of schizophrenics. British Journal of Psychiatry, 127, 109–18.Google Scholar
Kay, D. W. K., Cooper, A. F., Garside, R. F. & Roth, M. (1976b) The differentiation of paranoid from affective psychoses by patients premorbid characteristics. British Journal of Psychiatry, 129, 207–15.Google Scholar
Kendell, R. E. & Gourlay, J. (1970) The clinical distinction between the affective psychoses and schizophrenia. British Journal of Psychiatry, 117, 261–6.Google ScholarPubMed
Kidd, K. K. & Cavalli-Sforza, (1973) An analysis of the genetics of schizophrenia. Social Biology, 20, 254.Google Scholar
Kohn, M. L. (1976) The interaction of social class and other factors in the etiology of schizophrenia. American Journal of Psychiatry, 133, 177–80.Google Scholar
Laing, R. D. (1960) The Divided Self London: Tavistock.Google Scholar
Larson, C. A. & Nyman, G. E. (1970) Age of onset in schizophrenia. Human Heredity, 20, 241–7.Google Scholar
Larson, C. A. & Nyman, G. E. (1973) Differential fertility in schizophrenia. Acta Psychiatrica Scandinavica, 49, 272.CrossRefGoogle ScholarPubMed
Larson, C. A. & Nyman, G. E. (1974) Schizophrenia: outcome in a birth year cohort. Psychiatrica Clinica, 7, 50–5.Google Scholar
Leff, J. P. (1975) The maintenance of schizophrenic patients in the community. Studies of Schizophrenia, British Journal of Psychiatry Special Publication No. 10, 132–41.Google Scholar
Leonhard, K., Korff, I. & Schulz, H. (1962) Die Temperamente in den Familien der Monopolaren und Bipolaren phasischen Psychosen. Psychiatrie und Neurologie (Basel), 143, 416–34.Google Scholar
Lidz, T. (1973) The Origin and Treatment of Schizophrenic Disorders. New York: Basic Books.Google Scholar
Loranger, A. W. (1975) X-linkage and manic-depressive illness. British Journal of Psychiatry, 127, 482–8.CrossRefGoogle ScholarPubMed
McCabe, M. S. (1975) Reactive psychoses: a clinical and genetic investigation. Acta Psychiatrica Scandinavica, Supplement 239, 133.Google Scholar
McCabe, M. S. & Stromgren, E. (1975) Reactive psychoses. Archives of General Psychiatry, 32, 447.Google Scholar
McCabe, M. S., Fowler, R. C., Cadoret, R. J., Winokur, G. (1971) Familial difference in schizophrenia with good and poor prognosis. Psychological Medicine, 1, 326–32.Google Scholar
McCabe, M. S. & Cadoret, R. J. (1976) Genetic investigations of atypical psychoses. I. Morbidity in parents and siblings. Comprehensive Psychiatry, 17, 347.Google Scholar
Mednick, S. A., Mura, E., Schulsinger, F. & Mednick, B. (1971) Perinatal conditions and infant development in children with schizophrenic parents. Social Biology, 18, 103–13.Google Scholar
Mendlewicz, J. & Fleiss, J. L. (1974) Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illnesses. Biological Psychiatry, 9, 261.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1974) Morbidity risk and genetic transmission in manic-depressive illness. American Journal of Human Genetics, 26, 692701.Google Scholar
Mendlewicz, J. (1976) Genetic studies in schizoaffective illness. In The Impact of Biology on Modern Psychiatry, (eds Gershon, E. S., Belmaker, R. H., Kety, S. S., Rosenbaum, M.). New York: Plenum Pub. Co.Google Scholar
Mirdal, G. M., Rosenthal, D., Wender, P. H., Schulsinger, F. (1977) Perinatal complications in offspring of psychotic parents. British Journal of Psychiatry, 130, 494505.Google Scholar
Ödegaro, Ö, (1963) The psychiatric disease entities in the light of a genetic investigation. Acta Psychiatrica Scandinavica, Supplement 169.Google Scholar
Ödegaro, Ö, (1972) The multifactorial theory of inheritance in predisposition to schizophrenia. In Genetic Factors in Schizophrenia, ed Kaplan, A. R., pp 256–75.Google Scholar
Perris, C. ed (1976) A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica Supplement 194, Copenhagen.Google Scholar
Perris, C. (1974) A study of cycloid psychoses. Acta Psychiatrica Scandinavica, Supplement 253.Google Scholar
Rainer, J. D. (1975) Genetic knowledge and heredity counsellings: new responsibilities for psychiatry. In Genetic Research and Psychiatry. (Eds Fieve, R. R., Rosenthal, D. and Brill, H.). London: Johns Hopkins University.Google Scholar
Reed, S. C. (1972) Genetic counselling in schizophrenia in Genetic Factors in ‘Schizophrenia’, ed Kaplan, A. R. Springfield Ill, Thomas, pp 315–24.Google Scholar
Reich, T., Clayton, P. H. & Winokur, G. (1969) Family history studies: V. The genetics of mania. American Journal of Psychiatry, 125, 1358.CrossRefGoogle ScholarPubMed
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics, 36, 163.Google Scholar
Rieder, R. O., Broman, S. H. & Rosenthal, D. (1977) The offspring of schizophrenics II. perinatal factors and I.Q. Archives of General Psychiatry, 34, 789.Google Scholar
Reisby, N. (1967) Psychoses in children of schizophrenic mothers. Acta Psychiatrica Scandinavica, 43, 820.Google Scholar
Robins, L. N. (1966) Deviant Children Grown Up. Baltimore: Williams and Williams.Google Scholar
Rosenthal, D., Wender, P. H., Kety, S. S., Welner, J. & Schulsinger, F. (1971) The adopted-away offspring of schizophrenics. American Journal of Psychiatry, 128, 307–11.Google Scholar
Rosenthal, E. (1974) The concept of subschizophrenic disorders. In Genetics, Environment and Psychopathology (eds Mednick, S. A., Schulsinger, F., Higgins, J. and Bell, B.). Oxford: North-Holland Pub Co.Google Scholar
Rosenthal, D., Wender, P., Kety, S. S., Schulsinger, F., Welner, J. & Rieder, R. (1975) Parent-child relationships and psychopathological disorder in the child. Archives of General Psychiatry, 32, 466.Google Scholar
Sameroff, S. J. & Zax, M. (1973) Perinatal characteristics of the schizophrenic woman. Journal of Nervous and Mental Diseases, 157, 191–9.Google Scholar
Scharfetter, C. (1970) On the hereditary aspects of symbiotic psychoses: a contribution towards the understanding of the schizophrenia-like psychoses. Psychiatrica Clinica, 3, 145–52.Google Scholar
Schulsinger, F. (1972) Psychopathy: heredity and environment. International Journal of Mental Health, 1, 190.Google Scholar
Schulsinger, H. (1976). A ten-year follow-up of children of schizophrenic mothers. Clinical assessment. Acta Psychiatrica Scandinavica, 53, 371.Google Scholar
Slater, E. & Glithero, E. (1963) The schizophrenia-like psychoses of epilepsy 3: genetical aspects. British Journal of Psychiatry, 109, 130–3.CrossRefGoogle Scholar
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders. London: Oxford University Press.Google Scholar
Stenstedt, A. (1952) A study in manic-depressive psychoses. Acta Psychiatrica Scandinavica, Suppl. 79.Google Scholar
Stenstedt, A. (1959) Involutional melancholia: an aetiological, clinical and social study of endogenous depression in later life. Acta Psychiatrica Scandinavica, Suppl. 127.Google Scholar
Stephens, D. A., Atkinson, M. W., Kay, D. W. K., Roth, M. & Garside, R. F. (1976) Psychiatric morbidity in parents and sibs of schizophrenics and non-schizophrenics. British Journal of Psychiatry, 127, 97108.Google Scholar
Taylor, M. & Abrams, R. (1973) A genetic study of early and late onset affective disorders. Archives of General Psychiatry, 28, 656.CrossRefGoogle ScholarPubMed
Tsuang, M. T. (1967) A study of pairs of sibs both hospitalised for mental disorder. British Journal of Psychiatry, 113, 283.Google Scholar
Tsuang, M. T., Dempsey, G. M. & Rauscher, F. (1976) A study of ‘atypical schizophrenia’. Archives of General Psychiatry, 33, 1157.Google Scholar
Tsuang, M. T., Fowler, R. C., Cadoret, R. J. & Monnelly, E. (1974) Schizophrenia among first-degree relatives of paranoid and non-paranoid schizophrenics. Comprehensive Psychiatry, 15, 295.Google Scholar
Van Grieff, H., McHugh, P. R. & Stokes, P. E. (1975) The familial history in 16 males with bipolar manic-depressive illness. In Genetic Research in Psychiatry (eds Fieve, R. R., Rosenthal, D. and Brill, H.). London: John Hopkins University.Google Scholar
Videbech, T. (1975) A study of genetic factors, childhood bereavement, and premorbid traits in patients with anancastic endogenous depression. Acta Psychiatrica Scandinavica, 52, 178.Google Scholar
Wender, P. H., Rosenthal, D., Kety, S. S., Schulsinger, F. & Welner, J. (1974) Crossfostering: a research strategy for clarifying the role of genetic and experimental factors in the etiology of schizophrenia. Archives of General Psychiatry, 30, 121.Google Scholar
World Health Organisation (1969) Genetic Counselling. World Health Organisation Technical Report Series No. 416.Google Scholar
Winokur, G. & Clayton, P. (1967) Family history studies I. Two types of affective disorders separated according to genetic and clinical factors. In Recent Advances in Biological Psychiatry. Vol 9 (ed Wortis, J.). New York: Plenum Press. pp 3550.Google Scholar
Winokur, G., Cadoret, R., Dorzab, J. & Baker, M. (1971) Depressive disease. Archives of General Psychiatry, 24, 135.Google Scholar
Winokur, G., Morrison, J., Clancy, J. & Crowe, R. (1974) Iowa 500: the clinical and genetic distinction of hebephrenic and paranoid schizophrenia. Journal of Nervous and Mental Disease, 159, 12–9.Google Scholar
Winokur, G., Clayton, P. J. & Reich, T. (1969) Manic Depressive Illness, C. V. Mosby Co. USA.Google Scholar
Wood, D., Othmer, S., Reich, T., Viesselman, J. & Rutt, C. (1977) Primary and secondary affective disorder. I. Past social history and current episodes in 92 depressed inpatients. Comprehensive Psychiatry, 18, 201–10.Google Scholar
Zerbin-Rudin, E. (1967) Endogene Psychosen. In Humangenetik: ein kurzes Handbuch. V/2 ed Becker, P. E. Stuttgart.Google Scholar
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