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ANK3 gene expression in bipolar disorder and schizophrenia

  • Katrine Verena Wirgenes, Martin Tesli, Elin Inderhaug (a1), Lavinia Athanasiu (a1), Ingrid Agartz (a2), Ingrid Melle (a3), Timothy Hughes (a4), Ole Andreas Andreassen (a3) and Srdjan Djurovic (a5)...

Summary

ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for further investigation of the underlying mechanisms in psychotic disorders.

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Corresponding author

Martin Tesli, NORMENT, KG Jebsen Centre for Psychosis Research – TOP Study, Building 49, Oslo University Hospital, Ullevål, Kirkeveien 166, PO Box 4956 Nydalen, 0424 Oslo, Norway. Email: m.s.tesli@medisin.uio.no

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These authors contributed equally to this work.

The work was supported by the Research Council of Norway, the South-East Norway Regional Health Authority and KG Jebsen Foundation.

Declaration of interest

None.

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References

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ANK3 gene expression in bipolar disorder and schizophrenia

  • Katrine Verena Wirgenes, Martin Tesli, Elin Inderhaug (a1), Lavinia Athanasiu (a1), Ingrid Agartz (a2), Ingrid Melle (a3), Timothy Hughes (a4), Ole Andreas Andreassen (a3) and Srdjan Djurovic (a5)...
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