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Life-Threatening Allergic Reaction to Clozapine

Published online by Cambridge University Press:  02 January 2018

Gabriela Stoppe*
Affiliation:
University of Goettingen, Department of Psychiatry, Von-Siebold-Str. 5, 3400 Goettingen, Germany
Peter Müller
Affiliation:
University of Goettingen, Department of Psychiatry, Von-Siebold-Str. 5, 3400 Goettingen, Germany
Thomas Fuchs
Affiliation:
University of Goettingen, Department of Dermatology, Von-Siebold-Str. 3, 3400 Goettingen, Germany
Eckart Rüther
Affiliation:
University of Goettingen, Department of Psychiatry, Von-Siebold-Str. 5, 3400 Goettingen, Germany
*
Correspondence

Abstract

Clozapine, an ‘atypical’ antipsychotic drug, rarely induces allergic complications, which usually present as cutaneous reactions. We report the case of a 69-year-old woman, suffering from chronic schizophrenia, who developed an allergic asthmatic reaction following clozapine therapy. Intensive-care treatment was necessary. The reaction could be repeated by further exposure to the drug. Skin tests for hypersensitivity were negative.

Type
Brief Reports
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

Bürki, H. B. (1983) Neuroleptika: Grundlagen und Therapie. In Psychopharmaka, Grundlagen und Therapie (eds Langer, G. & Heimann, H.), pp. 205300. Wien, New York: Springer.Google Scholar
Fisher-Cornelssen, K. A. & Ferner, U. J. (1976) An example of European multi-center trials: multispectral analysis of clozapine. Psychopharmacology, 99, S97S100.Google Scholar
Grohmann, R., Strauss, A., Gehr, Ch., et al (1980) Zur Praxis der klinischen Therapie mit Psychopharmaka. Pharmakopsychiatry, 13, 119.CrossRefGoogle Scholar
Grohmann, R., Ruther, E., Sassim, N., et al (1989) Adverse effects of clozapine. Psychopharmacology, 99, S101S104.Google Scholar
Honigfeld, G., Patin, J. & Singer, J. (1984) Clozapine: antipsychotic activity in treatment-resistant schizophrenics. Advances in Therapy, 1, 7797.Google Scholar
Kane, J., Honigfeld, G., Singer, J., et al (1988) Clozapine for the treatment resistant schizophrenic. Archives of General Psychiatry, 45, 789796.Google Scholar
Lieberman, J., Johns, C., Cooper, T., et al (1989) Clozapine pharmacology and tardive dyskinesia. Psychopharmacology, 99, S54S59.CrossRefGoogle ScholarPubMed
Marder, S. R. & Van Putten, T. (1988) Who should receive clozapine? Archives of General Psychiatry, 45, 865867.Google Scholar
Meltzer, H. Y. (1989) Clozapine: clinical advantages and biological mechanisms. In Schizophrenia: A Scientific Focus. International Conference on Schizophrenia (eds Schulz, C. & Tamminga, C.), pp. 302309. New York: Oxford University Press.Google Scholar
Meltzer, H. Y., Bastani, B., Ramirez, L., et al (1989) Clozapine: new research on efficacy and mechanism of action. European Archives of Psychiatry and Neurological Sciences, 238, 332339.Google Scholar
Povlsen, U. J., Noring, U., Fog, R., et al (1985) Tolerability and therapeutic effect of clozapine. Acta Psychiatrica Scandinavica, 71, 176185.CrossRefGoogle Scholar
Simpson, G. M. (1978) Clozapine in tardive dyskinesia. Psychopharmacology, 56, 7580.Google Scholar
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