Abud, S., Souza, P.I.M., Moreira, C.T., Andrade, S.R.M., Ulbrich, A.V., Vianna, G.R., Rech, E.L. and Aragão, F.J.L. (2003) Gene flow in transgenic soybean in the Cerrado region, Brazil. Pesquisa Agropecuaria Brasileira 38, 1229–1235.
Abud, S., Souza, P.I.M., Vianna, G.R., Leonardecz, E., Moreira, C.T., Faleiro, F.G., Junior, J.N., Monteiro, P.M.F.O., Rech, E.L. and Aragão, F.J.L. (2007) Gene flow from transgenic to nontransgenic soybean plants in the Cerrado region of Brazil. Genetics and Molecular Research 6, 445–452.
Altpeter, F., Baisakh, N., Beachy, R., Bock, R., Capell, T., Christou, P., Daniell, D., Datta, K., Datta, S., Dix, P., Fauquet, C., Huang, N., Kohli, A., Mooibroek, H., Nicholson, L., Nguyen, T., Nugent, G., Raemakers, K., Romano, A., Somers, D., Stoger, E., Taylor, N. and Visser, R. (2005) Particle bombardment and the genetic enhancement of crops: myths and realities. Molecular Breeding 15, 305–327.
Aragão, F.J.L., Sarokin, L., Vianna, G.R. and Rech, E.L. (2000) Selection of transgenic meristematic cells utilizing a herbicidal molecule results in the recovery of fertile transgenic soybean (Glycine max (L.) Merril) plants at a high frequency. Theoretical and Applied Genetics 101, 1–6.
Aragão, F.J.L., Vianna, G.R., Carvalheira, S.B.R.C. and Rech, E.L. (2005) Germ line genetic transformation in cotton (Gossypium hirsutum L.) by selection of transgenic meristematic cells with a herbicide molecule. Plant Science 168, 1227–1233.
Ash, C., Jasny, B.R., Malakoff, D.A. and Sudgen, A.M. (2010) Feeding the future. Science 327, 797.
Babino, A., Pritsch, O., Oppezzo, P., Du Pasquier, R., Roseto, A., Osinaga, E. and Alzari, P.M. (1997) Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active Single-Chain Fv Fragment. Hybridoma 16, 317–324.
Barrett, C.L., Kim, T.Y., Kim, H.U., Palsson, B. and Lee, S.Y. (2006) Systems biology as a foundation for genome-scale synthetic biology. Current Opinion in Biotechnology 17, 488–492.
Baulcombe, D. (2010) Reaping benefits of crop research. Science 327, 761.
Bittencourt, D., Souto, B.M., Verza, N.C., Vinecky, F., Dittmar, K., Silva, P.I. Jr, Andrade, A.C., da Silva, F.R., Lewis, R.V. and Rech, E.L. (2007) Spidroins from the Brazilian spider Nephilengys cruentata (Araneae: Nephilidae). Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology 147, 597–606.
Bittencourt, D., Dittmar, K., Lewis, R.V. and Rech, E.L. (2010) A MaSp2-like gene found in the Amazon mygalomorph spider Avicularia juruensis. Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology 155, 419–426.
Bonfim, K., Faria, J.C., Nogueira, E.O.P.L., Mendes, E.A. and Aragão, F.J.L. (2007) RNAi-mediated resistance to Bean golden mosaic virus in genetically engineered common bean (Phaseolus vulgaris). Molecular Plant Microbe Interaction 20, 717–726.
Boothe, J.G., Saponja, J.A. and Parmenter, D.L. (1997) Molecular farming in plants: oilseeds as vehicles for the production of pharmaceutical proteins. Drug Development Research 42, 172–181.
Boothe, J., Nykiforuk, C., Shen, Y., Zaplachinski, S., Szarka, S., Kuhlman, P., Murray, E., Morck, D. and Moloney, M.M. (2010) Seed-based expression systems for plant molecular farming. Plant Biotechnology Journal 8, 588–606.
Botos, I., O'Keefe, B.R., Shenoy, S.R., Cartner, L.K., Ratner, D.M., Seeberger, P.H., Boyd, M.R. and Wlodawer, A. (2002) Structures of the complexes of a potent anti-HIV protein Cyanovirin-N and high mannose oligosaccharides. Journal of Biological Chemistry 277, 34 336–34 342.
Brookes, G. and Barfoot, P. (2008) Global impact of biotech crops: socio-economic and environmental effects. AgBioForum 11, 21–38.
Caldas, C., Coelho, V., Kalil, J., Moro, A.M., Maranhão, A.Q. and Brígido, M.M. (2003) Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen. Molecular Immunology 39, 941–952.
Cavazzoni, J., Volk, T., Bugbee, B. and Dougher, T. (1999) Phasic temperature and photoperiod control for soybean using a modified CROPGRO model. Life Support Biosphysical Science 6, 273–278.
Chen, Z.L., Schuler, M.A. and Beachy, R.N. (1986) Functional analysis of regulatory elements in a plant embryo-specific gene. Proceedings of the National Academy of Sciences, USA 83, 8560–8564.
Cunha, N.B., Murad, A.M., Cipriano, T.M., Araújo, A.C.G., Aragão, F.J.L., Leite, A., Vianna, G.R., McPhee, T.R., Souza, G.H.M.F., Waters, M.J. and Rech, E.L. (2010a) Expression of functional recombinant human growth hormone in transgenic soybean seeds. Transgenic Research 20, 811–826.
Cunha, N.B., Murad, A.M., Ramos, G.L., Maranhão, A.Q., Brigido, M.M., Araújo, A.C.G., Lacorte, C., Aragão, F.J.L., Covas, D.T., Fontes, A.M., Souza, G.H.M.F., Vianna, G.R. and Rech, E.L. (2010b) Accumulation of functional recombinant human coagulation factor IX in transgenic soybean seeds. Transgenic Research 20, 841–855.
Cunha, N.B., Araújo, A.C.G., Leite, A., Murad, A.M., Vianna, G.R. and Rech, E.L. (2010c) Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds. Genetics and Molecular Research 9, 1163–1170.
Daniell, H., Streatfield, S.J. and Wycoff, K. (2001) Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends in Plant Science 6, 219–226.
Endy, D. (2005) Foundations for engineering biology. Nature 438, 449–453.
Fedoroff, N.V., Battisti, D.S., Beachy, R.N., Cooper, P.J., Fischhoff, D.A., Hodges, C.N., Knauf, V.C., Lobell, D., Mazur, B.J., Molden, D., Reynolds, M.P., Ronald, P.C., Rosegrant, M.W., Sanchez, P.A., Vonshak, A. and Zhu, J.-K. (2010) Radically rethinking agriculture for the 21st century. Science 327, 833–834.
Gnjatic, S.H., Nishikawa, H., Jungbluth, A.A., Gure, A.O., Ritter, G., Jager, E., Knuth, A., Chen, Y.-T. and Old, L.J. (2003) NY-ESO-1: Review of an immunogenic tumor antigen. Advances in Cancer Research 95, 1–30.
Godfray, H.C.J., Beddington, J.R., Crute, I.R., Haddad, L., David Lawrence, D., Muir, J.F., Pretty, J., Robinson, S., Thomas, S.M. and Toulmin, C. (2010) Food security: the challenge of feeding 9 billion people. Science 327, 812–817.
Gullison, R.E., Frumhoff, P.C., Canadell, J.G., Field, C.B., Nepstad, D.C., Hayhoe, K., Avissar, R., Curran, L.M., Friedlingstein, P., Jones, C.D. and Nobre, C. (2007) Tropical forests and climate policy. Science 316, 985–986.
Imoto, Y., Yamada, T., Kitamura, K. and Kanazawa, A. (2008) Spatial and temporal control of transcription of the soybean beta-conglycinin alpha subunit gene is conferred by its proximal promoter region and accounts for the unequal distribution of the protein during embryogenesis. Genes Genetics Systems 83, 469–476.
James, C. (2010) .
Jolliffe, N.A., Craddock, C.P. and Frigerio, L. (2005) Pathways for protein transport to seed storage vacuoles. Biochemical Society Transactions 33, 1016–1018.
Kantolic, A.G. and Slafer, G.A. (2007) Development and seed number in indeterminate soybean as affected by timing and duration of exposure to long photoperiods after flowering. Annals of Botany 99, 925–933.
Kawakatsu, T. and Takaiwa, F. (2010) Cereal seed storage protein synthesis: fundamental processes for recombinant protein production in cereal grains. Plant Biotechnology Journal 8, 939–953.
Lewis, R.V. (2006) Spider silk: ancient ideas for new biomaterials. Chemical Review 106, 3762–3774.
Ma, J.K., Drake, P.M. and Christou, P. (2003) The production of recombinant pharmaceutical proteins in plants. Nature Reviews Genetics 4, 794–805.
McElroy, D. (2003) Sustaining agbiotechnology through lean times. Nature Biotechnology 21, 996–1002.
McElroy, D. (2004) Valuing the product development cycle in agricultural biotechnology – what's in a name. Nature Biotechnology 22, 817–822.
Merry, F.D., Amacher, G.S., Lima, E. and Nepstad, D.C. (2003) A risky forest policy in the Amazon? Science 299, 21.
Nagel, H., Laskawi, R., Eiffert, H. and Schlott, T. (2003) Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Journal of Clinical Pathology: Molecular Pathology 56, 226–231.
Nepstad, D., Schwartzman, B., Bamberger, B., Santilli, M., Ray, D., Schlesinger, P., Lefebcre, P., Alencar, A., Prinz, E., Fiske, G. and Rolla, A. (2006a) Inhibition of Amazon deforestation and fire by parks and indigenous lands. Conservation Biology 20, 65–73.
Nepstad, D., Sticker, C.M. and Almeida, O.T. (2006b) Globalization of the Amazon soy and beef industries: opportunities for conservation. Conservation Biology 20, 1595–1603.
Obembe, O.O., Popoola, J.O., Leelavathi, S. and Reddy, S.V. (2011) Advances in plant molecular farming. Biotechnology Advances 29, 210–222.
OECD/FAO (2010) The growing problem. Nature 466, 546–547.
O'Keefe, B.R., Vojdani, F., Buffa, V., Shattock, R.J., Montefiori, D.C., Bakke, J., Mirsalis, J., d'Andrea, A.-L., Hume, S.D., Bratcher, B., Saucedo, C.J., McMahon, J.B., Pogue, G.P. and Palmer, K.P. (2009) Scalable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proceedings of the National Academy of Sciences, USA 106, 6099–6104.
Pennisi, E. (2010) Sowing the seeds for the ideal crop. Science 327, 802–803.
Peres, C.A. and Terborgh, J.W. (1995) Amazonian nature reserves: an analysis of the defensibility status of existing conservation units and design criteria for the future. Conservation Biology 9, 34–46.
Ratter, J.A., Bridgewater, S. and Ribeiro, J.F. (2003) Analysis of the floristic composition of the Brazilian cerrado vegetation III: comparison of the woody vegetation of 376 areas. Edinburgh Journal of Botany 60, 57–109.
Rech, E.L., Vianna, G.R. and Aragão, F.J.L. (2008) High-efficiency transformation by biolistics of soybean, common bean and cotton transgenic plants. Nature Protocols 3, 410–418.
Robić, G., Farinas, C.S., Rech, E.L., Bueno, S.M.A. and Miranda, E.A. (2006) Downstream process engineering evaluation of transgenic soybean seeds as host for recombinant protein production. Biochemical Engineering Journal 32, 7–12.
Robić, G., Farinas, C.S., Rech, E.L. and Miranda, E.A. (2010) Transgenic soybean seed as protein expression system: aqueous extraction of recombinant beta-glucuronidase. Applied Biochemistry and Biotechnology 160, 1157–1167.
Sachs, J., Remans, R., Smukler, S., Winowiecki, L., Andelman, S.J., Cassman, K., Castle, D., DeFries, R., Denning, G., Fanzo, J., Jackson, L.E., Leemans, R., Lehmann, J., Milder, J.C., Naeem, S., Nziguheba, G., Palm, C.A., Pingalli, P.L., Reganold, J.P., Richter, D.D., Scherr, S.J., Sircely, J., Sullivan, C., Tomich, T.P. and Sanchez, P.A. (2010) Monitoring the world's agriculture. Nature 466, 558–560.
Sathasivan, K., Haughn, G.W. and Murai, N. (1990) Nucleotide sequence of a mutant acetolactate synthase gene from an imidazolinone resistant Arabidopsis thaliana var. Columbia. Nucleic Acids Research 18, 2188.
Schwartzman, S., Moreira, A.G. and Nepstad, D.C. (2000) Rethinking tropical forest conservation: perils in parks. Conservation Biology 14, 1351–1357.
Shaner, D.L., Anderson, P.C. and Stidham, M.A. (1984) Imidazolinones: potent inhibitors of acetohydroxyacid synthase. Plant Physiology 76, 534–546.
Silva, W.A. Jr, Gnjatic, S., Erika Ritter, E., Chua, R., Cohen, T., Hsu, M., Jungbluth, A.A., Altorki, N.K., Chen, Y.-T., Old, L.J., Simpson, A.J.G. and Caballero, O.L. (2007) A trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses. Cancer Immunity 7, 18–27.
Soares-Filho, B.S., Nepstad, D.C., Curran, L.M., Cerqueira, G.C., Garcia, R.A., Ramos, C.A., Voll, E., McDonald, A., Lefebvre, P. and Schlesinger, P. (2006) Modelling conservation in the Amazon basin. Nature 440, 520–523.
Spök, A., Twyman, R.M., Fischer, R., Ma, J.K.C. and Sparrow, A.C. (2008) Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants. Trends in Biotechnology 26, 506–517.
Stoger, E., Ma, J.K., Fischer, R. and Christou, P. (2005) Sowing the seeds of success: pharmaceutical proteins from plants. Current Opinion in Biotechnology 16, 167–173.
Streatfield, S.J. (2007) Approaches to achieve high-level heterologous protein production in plants. Plant Biotechnology Journal 5, 2–15.
Teulé, F., Cooper, A.R., Furin, W.A., Bittencourt, D., Rech, E.L., Brooks, A. and Lewis, R.V. (2009) A protocol for the production of recombinant spider silk-like proteins for artificial fiber spinning. Nature Protocols 4, 341–355.
Tollefson, J.T. (2010) The global farm. Nature 466, 554–556.
Van den Eynde, B., Peeters, O., De Backer, O., Gaugler, B., Lucas, S. and Boon, T. (1995) A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. Journal of Experimental Medicine 182, 689–698.
Weber, W. and Fusseneger, M. (2009) The impact of synthetic biology on drug discovery. Drug Discovery Today 14, 956–963.
Xiong, C., O'Keefe, B.R., Botos, I., Wlodawer, A. and McMahon, J.B. (2006) Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expression and Purification 46, 233–239.