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A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis

  • MALI ILLANGASEKARE (a1) and MICHAEL YARUS (a1)

Abstract

A 29-nt RNA catalyst successively forms the aminoacyl ester phe-RNA, and then peptidyl-RNA (phe-phe-RNA), given phenylalanine adenylate (phe-AMP) as substrate. Catalysis of two related reactions at similar rates supports the argument that RNA catalysts would evolve as groups with similar mechanisms. In particular, successive aminoacyl- and peptidyl-RNA synthesis by one RNA suggests that uncoded but RNA-catalyzed peptide synthesis would evolve before the synthesis of coded peptides.

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Corresponding author

Reprint requests to: Michael Yarus, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA; e-mail: yarus@stripe.colorado.edu.

Keywords

A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis

  • MALI ILLANGASEKARE (a1) and MICHAEL YARUS (a1)

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