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The inflammatory process in aging

  • Hae Young Chung (a1), Hyon Jeen Kim (a1), Kyung Jin Jung (a1), Ji Sung Yoon (a1), Mi Ae Yoo (a1), Kyu Won Kim (a1) and Byung Pal Yu (a1)...

Abstract

Aging processes are time-dependent, deteriorative functional changes. These functional changes lead to a progressive loss of the organism’s ability to withstand both internal and environmental stresses, causing the failure of cellular homeostasis. Among the modern hypotheses, the ‘Oxidative Stress Hypothesis’ offers the best mechanistic elucidation of aging phenomena. Based on the ‘Free Radical Theory of Aging’, this hypothesis has gained popularity among researchers in the field of gerontology as well as other biomedical fields. Its primary premise proposes that aging and its related disease processes are the net result of free radical-induced damage, asserting further that an organism’s inability to produce counterbalancing antioxidative defences, i.e. defences that offset disturbances in the redox state, underlies its cause.

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Corresponding author

Address for correspondence: Byung Pal Yu, Department of Molecular Biology, Pusan National University, Gumjung-Ku, Pusan 609-735, Korea.

The inflammatory process in aging

  • Hae Young Chung (a1), Hyon Jeen Kim (a1), Kyung Jin Jung (a1), Ji Sung Yoon (a1), Mi Ae Yoo (a1), Kyu Won Kim (a1) and Byung Pal Yu (a1)...

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