1Fan, E, Ferguson, ND. One for all and all for one? The globalization of critical care. Crit Care Med 2008; 36: 2942–43.
2Millibrandt, EB, Eldadah, B, Nayfield, Set al.Toward an Integrated research agenda for critical illness in aging. Am J Repir Crit Care Med 2010; 182: 995–1003.
3Nguyen, Y-L, Angus, DC, Boumendil, Aet al.The challenges of admitting the very elderly to intensive care. Ann Intensive Care 2011; 1: 29.
4Wilson, DM, Thurston, A, Lichlyter, Bet al.Should the oldest-old be admitted to the intensive care unit and receive advanced life-supporting care? Crit Care Med 2010; 38: 303–4.
5Boumendil, A, Somme, D, Garrouste-Orgeas, Met al.Should elderly patients be admitted to the intensive care unit? Intensive Care Med 2007; 33: 1252–62.
6Bagshaw, SM, Webb, SA, Delaney, Aet al.Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care 2009; 13: R45.
7de Rooij, SE, Govers, AC, Korevaar, JCet al.Cognitive, functional and quality of life outcomes of patients aged 80 or older who survived at least 1 year after planned or unplanned surgery or medical intensive care treatment. J Am Geriatr Soc 2008; 56: 816–22.
8Lerolle, N, Trinquart, L, Bornstein, Cet al.Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Crit Care Med 2010; 8: 59–64.
9Roch, A, Wiramus, S, Pauly, Vet al.Long term outcome in medical patients aged 80 or over following admission to an intensive care unit. Crit Care 2011; 15: R36
10Tabah, A, Philippart, F, Timsit, JFet al.Quality of life in patients aged 80 or over after ICU discharge. Crit Care 2010; 14: R2.
11Nathanson, BH, Higgins, TL, Brennan, MJet al.Do elderly patients fare well in ICU? Chest 2011; 139: 825–31.
12Fuchs, L, Chronaki, CE, Park, Set al.ICU admission characteristics and mortality rates among elderly and very elderly patients. Intensive Care Med doi: 10.1007/s00134-012-2629-6.
13Boumendil, A, Aegerter, P, Guidet, B. Treatment intensity and outcomes of patients aged 80 and older in intensive care units: a multi-center matched-cohort study. J Am Geriatr Soc 2005; 53: 88–93.
14Pisani, MA, Redlich, C, McNicholl, Let al.Under-recognition of pre-existing cognitive impairment by physicians in older ICU patients. Chest 2003; 124: 2267–74.
15Girard, T, Pandharipande, P, Ely, EW. Delirium in the intensive care unit. Crit Care 2008; 12: S3.
16Bo, M, Massaia, M, Raspo, Set al.Predictive factors of in-hospital mortality in older patients admitted to a medical intensive care unit. J Am Geriatr Soc 2003; 51: 529–33.
17Sprung, CL, Artigas, A, Kesecioglu, Jet al.The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: Intensive care benefit for elderly. Crit Care Med 2012; 40: 132–38.
18Boumendil, A, Angus, DC, Guitonneau, A-Let al.Variability of intensive care decisions for the very elderly. PLoS ONE 2012; 7: e34387. doi: 10.1371/journal.pone.0034387.
19de Rooij, Se, Abu-Hanna, A, Levi, Met al.Identification of high-risk subgroups in very elderly intensive care unit patients. Critical Care 2007; 11: R33.
20Angus, DC, Linde-Zwirble, WT, Lidicker, Jet al.Epidemiology of severe sepsis in the United States: analysis of incidence and outcome and associated costs of care. Crit Care Med 2001; 29: 303–10.
21Girard, TD, Opal, SM, Ely, EW. Insights into severe sepsis in older patients: from epidemiology to evidence-based management. Clinical Infectious Diseases 2005; 40: 719–27.
22Desterac, LA, Ely, EW. Sepsis in older patients: an emerging concern in critical care. Advances in Sepsis 2002; 2: 15–22.
23Gavazzi, G, Krause, KH. Ageing and infection. Lancet Infect Dis 2002; 2: 659–66.
24Norman, DC. Fever and aging. Infect Dis Clin Pract 1998; 7: 387–90.
25Bellmann-Weiler, R, Weiss, G. Pitfalls in the diagnosis and therapy of infections in elderly patients – a mini-review. Gerontology 2009; 55: 241–49.
26Scheutz, P, Christ-Crain, M, Muller, B. Procalcitonin and other biomarkers to improve assessment and antibiotic stewardship in infections – hope for hype? Swiss Med Wkly 2009; 139: 319–26.
27Martin, GS, Mannino, DM, Moss, M.The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006; 34: 15–21.
28Dellinger, RP, Levy, MM, Carlet, JMet al.Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock. Intensive Care Medicine 2008; 34: 17–60.
29Rivers, E, Nguyen, B, Havstad, Set al.Early goal directed therapy in the treatment of severe sepsis nad septic shock. N Engl J Med 2001; 345: 1368–77.
30The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301–8.
31Ranieri, VM, Thompson, BT, Barie, PSet al.Drotrcogin alfa (activated) in adults with septic shock. N Engl Med 2012; 366: 2055–64.
32Behrendt, CE. Acute respiratory failure in the United States: incidence and 31-day survival. Chest 2000; 118: 1100–5.
33Ray, P, Birolieau, S, Lefort, Yet al.Acute respiratory failure in the elderly: etiology, emergency diagnosis and prognosis. Critical Care 2006; 10: R82.
34Ely, EW, Wheeler, AP, Thompson, BTet al.Recovery rate and prognosis in older persons who develop acute lung injury and acute respiratory distress syndrome. Ann Intern Med 2002; 136: 25–36.
35Delerme, S, Ray, P. Acute respiratory failure in the elderly: diagnosis and prognosis. Age and Ageing 2008; 37: 251–57.
36Severansky, JE, Haponik, EF. Respiratory failure in elderly patients. Clin Geriatr Med 2003; 19: 205–24.
37Masip, J, Roque, M, Sánchez, Bet al.Non-invasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis. JAMA 2005; 294: 3124–30.
38Plant, PK, Owen, JL, Elliott, MW. A multicentre randomised controlled trial of the early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. Lancet 2000; 355: 1931–35.
39Confalonieri, M, Potena, , Carbone, Get al.Acute respiratory failure in patients with severe community acquired pneumonia. A prospective randomized evaluation of non-invasive ventilation. Am J Respir Crit Care Med 1999; 160: 1585–91.
40Niu, N, Lorente, JA, De Paula, Met al.Ageing increases the susceptibility to injurious mechanical ventilation. Intensive Care Med 2008; 34: 923–31.
41Herridge, MS, Cheung, AM, Tansey, CMet al.One-year outcome in survivors of acute respiratory distress syndrome. N Engl J Med 2003; 348: 683–93.
42Girard, TD, Kress, JP, Fuchs, BDet al.Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised control trial. Lancet 2008; 371: 126–34.
43Chelluri, L, Im, KA, Belle, SHet al.Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 2004; 32: 25–36.
44Joannidis, M, Metnitz, B, Bauer, Pet al.Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS3 database. Intensive Care Med 2009; 35: 1692–702.
45Chronopoulos, A, Rosner, MH, Cruz, Det al.Acute kidney injury in elderly intensive care patients: a review. Intensive Care Med 2010; 36: 1454–64.
46Feest, TG, Round, A, Hamad, S. Incidence of severe acute renal failure in adults: results of a community-based study. BMJ 1993; 306: 481–83.
47Uchino, S, Kellum, JA, Bellomo, Ret al.Acute renal failure in critically ill patients. A multinational, multicenter study. JAMA 2005; 294: 813–18.
48Rosner, MH. Acute kidney injury in the elderly: pathogenesis, diagnosis and therapy. Aging Health 2009; 5: 635–46.
49Joannidis, M, Druml, W, Forni, LGet al.Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the working group for nephrology, ESICM. Intensive Care Med 2010; 36: 392–411.
50Bellomo, R, Wan, L, May, C. Vasoactive drugs and acute kidney injury. Crit Care Med 2008; 36: S179–86.
51Pearse, R, Dawson, D, Fawcett, Jet al.Early goal directed therapy after major surgery reduces complications and duration of hospital stay. A randomised controlled trial. Critical Care 2005; 9: R687–93.
53Bagshaw, SM, Laupland, KB, Doid, CJet al.Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population- based study. Crit Care 2005; 9: R700–9.
54Girard, TD, Pandharipande, PP, Ely, EW. Delirium in the intensive care unit. Critical Care 2008; 12 (suppl 3): S3.
55Pun, BT, Ely, EW. The importance of diagnosing and managing delirium in ICU. Chest 2007; 132: 624–36.
56Ely, EW, Shintani, A, Truman, Bet al.Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291: 1753–62.
57Ely, EW, Gautam, S, Margolin, Ret al.The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001; 27: 1892–900.
58Hopkins, RO, Jackson, JC. Long-term neurocognitive function after critical illness. Chest 2006; 130: 869–78.
59Ely, EW, Inouye, SK, Bernard, GRet al.Delirium in mechanically ventilated patients: validity and reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). JAMA 2001; 286: 2703–10.
60Griffiths, RD, Jones, C. Seven lessons from 20 years of follow-up of intensive care survivors. Curr Opin Crit Care 2007; 13: 508–13.
61Griffiths, JA, Gager, M, Waldmann, C. Follow-up after intensive care. Continuing Education in Anaesth Crit Care and Pain 2004; 4: 202–5.
62Herridge, MS, Tansey, CM, Matté, Aet al.Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011; 364: 1293–304.
63Hopkins, RO, Weaver, LK, Collingridge, Det al.Two year cognitive, emotional and quality of life outcomes in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2005; 171: 340–47.
64O'Donnell, ML, Creamer, M, Holmes, ACet al.Post traumatic stress disorder after injury: does admission to intensive care unit increase risk. J Trauma 2010; 69: 627–32.