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Gonadotropin releasing hormone agonists and hormone replacement theory
Published online by Cambridge University Press: 03 June 2009
Extract
It has been clearly demonstrated that GnRHa is a powerful suppressant of ovarian steroidogenesis and, as a result, provides alternative strategies in dealing with certain gynaecological disorders. A concern for the deleterious effects of oestrogen deprivation is underscored by the potential long-term application of these compounds. Available studies indicate that concomitant HRT, whether physiological or pharmacological, may be utilized with good results. However, there is a great need to further explore the benefit and risks of supplementation therapy.
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- Copyright © Cambridge University Press 1996