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Le Flt3-ligand plasmatique, un bio-indicateur pronostique de l'atteinte radio-induite à la moelle osseuse

Published online by Cambridge University Press:  17 June 2005

J.-M. Bertho ,
J. Frick ,
C. Demarquay ,
J. Ph. Laporte ,
J. Aigueperse ,
N.-C. Gorin  and
P. Gourmelon
J.-M. Bertho
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
J. Frick
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
C. Demarquay
Affiliation:
Laboratoire de Radio-hématologie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France. Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France.
J. Ph. Laporte
Affiliation:
Service des maladies du sang, Hôpital St. Antoine, Paris, France.
J. Aigueperse
Affiliation:
Section autonome de radiologie appliquée à la médecine, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France.
N.-C. Gorin
Affiliation:
Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France. Service des maladies du sang, Hôpital St. Antoine, Paris, France.
P. Gourmelon
Affiliation:
Laboratoire de thérapie cellulaire et de radioprotection accidentelle, CHU St. Antoine, Paris, France. Département de protection de la santé de l'Homme et de dosimétrie, IPSN, BP 6, 92265 Fontenay-aux-Roses Cedex, France.
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Abstract

Plasma Flt3-ligand as a prognostic bio-indicator of radiation-induced bone marrow damage. Following an accidental irradiation, the choice between different therapeutic strategies mainly depends upon the estimated radiation-induced bone marrow damage. It was shown recently that the serum concentration of Flt3-ligand (FL), a cytokine mainly acting on immature haemopoietic cells, is highly elevated in either acquired or induced bone marrow aplasia. This suggested to us that FL measurement could be used as a bio-indicator of radiation-induced bone marrow damage. In order to verify this hypothesis, studies were conducted in a non human primate model as well as in humans undergoing radio and/or chemotherapy. Results showed that the increase in FL concentration on day 5 after irradiation is predictive of the evolution of the haemopoietic syndrome. Similar results were obtained in humans. Overall these results suggested that FL measurement could be used as a reliable bio-indicator of radiation-induced bone marrow damage in accidental irradiation situations.

Keywords

biological indicatorshaematopoietic systembone marrowexposure, acuteaccident
Type
Research Article
Information
Radioprotection , Volume 36 , Issue 3 , July 2001 , pp. 303 - 315
Copyright
© EDP Sciences, 2001

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