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Frontier methods in coherent X-ray diffraction for high-resolution structure determination

Published online by Cambridge University Press:  12 December 2016

Marcus Gallagher-Jones ,
Jose A. Rodriguez  and
Jianwei Miao
Marcus Gallagher-Jones
Affiliation:
Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA
Jose A. Rodriguez*
Affiliation:
Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, California 90095, USA
Jianwei Miao*
Affiliation:
Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA
*
*Author for correspondence: J. A. Rodriguez and J. Miao, Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA. Tel.: 310-206-2645; Fax: 310-206-5668; Email: jrodriguez@mbi.ucla.edu or miao@physics.ucla.edu
*Author for correspondence: J. A. Rodriguez and J. Miao, Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA. Tel.: 310-206-2645; Fax: 310-206-5668; Email: jrodriguez@mbi.ucla.edu or miao@physics.ucla.edu
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Abstract

In 1912, Max von Laue and collaborators first observed diffraction spots from a millimeter-sized crystal of copper sulfate using an X-ray tube. Crystallography was born of this experiment, and since then, diffraction by both X-rays and electrons has revealed a myriad of inorganic and organic structures, including structures of complex protein assemblies. Advancements in X-ray sources have spurred a revolution in structure determination, facilitated by the development of new methods. This review explores some of the frontier methods that are shaping the future of X-ray diffraction, including coherent diffractive imaging, serial femtosecond X-ray crystallography and small-angle X-ray scattering. Collectively, these methods expand the current limits of structure determination in biological systems across multiple length and time scales.

Type
Review
Information
Quarterly Reviews of Biophysics , Volume 49 , 2016 , e20
Copyright
Copyright © Cambridge University Press 2016 

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