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The structure of branched DNA species

Published online by Cambridge University Press:  17 March 2009

David M. J. Lilley
CRC Nucleic Acid Structure Group, Department of Biochemistry, The University, Dundee DD1 4HN, U.K.
Robert M. Clegg
Abteilung Molekulare Biologie, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg, D-3400 Göttingen, Federal Republic of Germany


Branched DNA molecules provide a challenging set of structural problems. Operationally we define branched DNA species as molecules in which double helical segments are interrupted by abrupt discontinuities, and we draw together a number of different kinds of structure in the class, including helical junctions of different orders, and base bulges (Fig. 1).

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