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DNA and RNA: NMR studies of conformations and dynamics in solution

Published online by Cambridge University Press:  17 March 2009

Dinshaw J. Patel
Affiliation:
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
Lawrence Shapiro
Affiliation:
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
Dennis Hare
Affiliation:
Infinity Systems, 14810 2156 Avenue NW, Woodinville, Washington 98072

Extract

The early NMR research on nucleic acids was of a qualitative nature and was restricted to partial characterization of short oligonucleotides in aqueous solution. Major advances in magnet design, spectrometer electronics, pulse techniques, data analysis and computational capabilities coupled with the availability of pure and abundant supply of long oligonucleotides have extended these studies towards the determination of the 3-D structure of nucleic acids in solution.

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Research Article
Copyright
Copyright © Cambridge University Press 1987

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