A progress report of the MASTER project is presented here. MASTER is a system of three heterodyne receivers based on SIS (superconductor–insulator–superconductor) tunnel junction mixers. In our instrument these mixers will allow direct down-conversion from 94, 225, and 345 to 1.5 GHz, the IF where the signal will be detected. This instrument, coupled to a 2–4 m telescope like the one proposed for the DOME C base in Antarctica and in conjunction with an Acusto Optical Spectrometer, can be used to detect emission lines associated with molecular clouds in the interstellar medium. The current status of a 94 GHz receiver, the prototype of MASTER, will be presented too. The study of the optical coupling between the receiver and MITO telescope in the Italian Alps will also be described.