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Waist-to-height ratio, inflammation and CVD risk in obese children

  • Josune Olza (a1), Concepcion M Aguilera (a1), Mercedes Gil-Campos (a2), Rosaura Leis (a3), Gloria Bueno (a4), Miguel Valle (a5), Ramon Cañete (a2), Rafael Tojo (a3), Luis A Moreno (a6) and Angel Gil (a1)...

Abstract

Objective

To evaluate the association between waist-to-height ratio (WHtR) and specific biomarkers of inflammation, CVD risk and endothelial dysfunction in prepubertal obese children.

Design

Prospective, multicentre case–control study matched by age and sex.

Setting

Children were recruited between May 2007 and May 2010 from primary-care centres and schools in three cities in Spain (Cordoba, Santiago de Compostela and Zaragoza).

Subjects

Four hundred and forty-six (223 normal weight and 223 obese) Caucasian prepubertal children aged 6–12 years.

Results

WHtR was higher in the obese than in the normal-weight children. Blood pressure, waist circumference, weight, height, insulin, plasma lipids, leptin, resistin, abnormal neutrophil and monocyte counts, C-reactive protein, IL-6, IL-8, TNF-α, myeloperoxidase, soluble intercellular adhesion molecule-1, selectin and plasminogen activator inhibitor-1 levels were higher in the obese than in the normal-weight group. Adiponectin and HDL-cholesterol were lower and glucose and metalloproteinase-9 showed no differences. Resistin, TNF-α and active plasminogen activator inhibitor-1 were associated with WHtR, a sensitive indicator of central obesity.

Conclusions

Our results lead to the hypothesis that changes in biomarker levels of insulin resistance, inflammation and CVD risk before puberty might induce metabolic consequences of obesity in obese children before reaching adulthood.

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Copyright

Corresponding author

*Corresponding author: Email jolza@ugr.es

References

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1.Ouchi, N, Parker, JL, Lugus, JJet al. (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11, 8597.
2.Tzanavari, T, Giannogonas, P & Karalis, KP (2010) TNF-α and obesity. Curr Dir Autoimmun 11, 145156.
3.Schwartz, DR & Lazar, MA (2011) Human resistin found in translation from mouse to man. Trends Endocrinol Metab 22, 259265.
4.Weyer, C, Yudkin, JS, Stehouwer, CDet al. (2002) Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 161, 233242.
5.Lloyd, LJ, Langley-Evans, SC & McMullen, S (2010) Childhood obesity and adult cardiovascular disease risk: a systematic review. Int J Obes (Lond) 34, 1828.
6.Browning, LM, Hsieh, SD & Ashwell, M (2010) A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0·5 could be a suitable global boundary value. Nutr Res Rev 23, 247269.
7.Soto González, A, Bellido, D, Buño, MMet al. (2007) Predictors of the metabolic syndrome and correlation with computed axial tomography. Nutrition 23, 3645.
8.Ashwell, M, Cole, TJ & Dixon, AK (1996) Ratio of waist circumference to height is strong predictor of intraabdominal fat. BMJ 313, 559560.
9.Li, M, Fisette, A, Zhao, XYet al. (2009) Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents. Int J Obes (Lond) 33, 424439.
10.Mantovani, RM, Rios, DR, Moura, LCet al. (2011) Childhood obesity: evidence of an association between plasminogen activator inhibitor-1 levels and visceral adiposity. J Pediatr Endocrinol Metab 24, 361367.
11.Huang, RC, de Klerk, N, Mori, TAet al. (2011) Differential relationships between anthropometry measures and cardiovascular risk factors in boys and girls. Int J Pediatr Obes 6, e271e282.
12.Cossio, S, Messiah, SE, Garibay-Nieto, Net al. (2009) How do different indices of obesity correlate with cardiometabolic disease risk factors in multiethnic youths? Endocr Pract 15, 403409.
13.Corvalan, C, Uauy, R, Kain, Jet al. (2010) Obesity indicators and cardiometabolic status in 4-y-old children. Am J Clin Nutr 91, 166174.
14.Kleiser, C, Schienkiewitz, A, Schaffrath Rosario, Aet al. (2011) Indicators of overweight and cardiovascular disease risk factors among 11- to 17-year-old boys and girls in Germany. Obes Facts 4, 379385.
15.Brooks, GC, Blaha, MJ & Blumenthal, RS (2010) Relation of C-reactive protein to abdominal adiposity. Am J Cardiol 106, 5661.
16.Cole, TJ, Bellizzi, MC, Flegal, KMet al. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320, 12401243.
17.Cole, TJ, Freeman, JV & Preece, MA (1990) Body mass index reference curves for the UK, 1990. Arch Dis Child 73, 2529.
18.McCrindle, BW (2010) Assessment and management of hypertension in children and adolescent. Nat Rev Cardiol 7, 155163.
19.Madjid, M, Awan, I, Willerson, JTet al. (2004) Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol 44, 19451956.
20.Skinner, AC, Steiner, MJ, Henderson, FWet al. (2010) Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. Pediatrics 125, e801e809.
21.Hara, M, Saitou, E, Iwata, Fet al. (2010) Waist-to-height ratio is the best predictor of cardiovascular disease risk factors in Japanese school children. J Atheroscler Thromb 9, 127132.
22.Ruiz, JR, Ortega, FB, Loit, HMet al. (2007) Body fat is associated with blood pressure in school-aged girls with low cardiorespiratory fitness: the European Youth Heart Study. J Hypertens 25, 20272034.
23.Botton, J, Heude, B, Kettaneh, Aet al. (2007) Cardiovascular risk factor levels and their relationships with overweight and fat distribution in children: the Fleurbaix Laventie Ville Santé II study. Metabolism 56, 614622.
24.Freedman, DS, Dietz, WH, Srinivasan, SRet al. (2009) Risk factors and adult body mass index among overweight children: the Bogalusa Heart Study. Pediatrics 123, 750757.
25.DeBoer, MD (2013) Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions. Nutrition 29, 379386.
26.Hickman, TB, Briefel, RR, Carroll, MDet al. (1998) Distributions and trends of serum lipid levels among United States children and adolescents ages 4–19 years: data from the Third National Health and Nutrition Examination Survey. Prev Med 27, 879890.
27.National Heart, Lung, and Blood Institute, National Cholesterol Education Program (1991) Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Publication no. NIH91-2732. Bethesda, MD: National Institutes of Health.
28.Steene-Johannessen, J, Kolle, E, Reseland, JEet al. (2010) Waist circumference is related to low-grade inflammation in youth. Int J Pediatr Obes 5, 313319.
29.Stofkova, A (2010) Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul 44, 2536.
30.Cigolini, M, Targher, G, Bergamo Andreis, IAet al. (1996) Visceral fat accumulation and its relation to plasma hemostatic factors in healthy men. Arterioscler Thromb Vasc Biol 16, 368374.
31.Caballeros, AE, Bousquet-Santos, K, Robles-Osorio, Let al. (2008) Overweight Latin children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance. Diabetes Care 31, 576582.
32.Janand-Delenne, B, Chagnaud, C, Raccah, Det al. (1998) Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women. Int J Obes Relat Metab Disord 22, 312317.
33.Wu, SH, Shu, XO, Chow, WHet al. (2013) Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women. Dis Markers 34, 279293.

Keywords

Waist-to-height ratio, inflammation and CVD risk in obese children

  • Josune Olza (a1), Concepcion M Aguilera (a1), Mercedes Gil-Campos (a2), Rosaura Leis (a3), Gloria Bueno (a4), Miguel Valle (a5), Ramon Cañete (a2), Rafael Tojo (a3), Luis A Moreno (a6) and Angel Gil (a1)...

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