Skip to main content Accessibility help
×
Home

Selenium level is associated with apoE ε4 in rural elderly Chinese

  • Sujuan Gao (a1), Yinlong Jin (a2), Kathleen S Hall (a3), Chaoke Liang (a2), Frederick W Unverzagt (a3), Feng Ma (a2), Yibin Cheng (a2), Jianzhao Shen (a1), Jingxiang Cao (a2), Janetta Matesan (a1), Ping Li (a4), Jianchao Bian (a5), Hugh C Hendrie (a3) (a6) (a7) and Jill R Murrell (a8)...

Abstract

Objective

Se is an essential trace element in human nutrition associated with antioxidant activity. Previous studies on predictors of toenail Se or serum Se have mostly concentrated on demographic factors such as age and gender. The present paper examines the association between apoE genotype and Se levels in nail samples in a rural elderly Chinese cohort.

Design

Two thousand Chinese aged 65 years and over from four counties in China were enrolled in a cohort to study the association of Se with cognitive decline. Nail samples were collected from each participant and analysed for Se levels. Dietary Se intake was estimated from an FFQ using Se contents measured in food items collected from each village. Blood samples on filter cards were collected and analysed for apoE genotype. Mixed-effect models were constructed with nail Se level as the dependent variable and each village as the random effect, which controlled for the potential confounding effect from correlation in Se measures obtained from participants residing in the same village.

Results

In this elderly Chinese cohort, carriers of the apoE ε4 allele had significantly lower Se levels measured in nail samples than non-carriers after adjusting for other significant covariates and controlling for estimated dietary Se intake. There was no significant difference between the two genotypes on estimated Se dietary intake (P = 0·6451).

Conclusions

Future studies are needed to examine the mechanism underlying the association between the apoE ε4 allele and Se levels, including the role of oxidative stress and that of reduced lipid metabolism in the apoE ε4 carriers.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Selenium level is associated with apoE ε4 in rural elderly Chinese
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Selenium level is associated with apoE ε4 in rural elderly Chinese
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Selenium level is associated with apoE ε4 in rural elderly Chinese
      Available formats
      ×

Copyright

Corresponding author

*Corresponding author: Email sgao@iupui.edu

References

Hide All
1.Flatt, A, Pearce, N, Thomson, CD, Sears, MR, Robinson, MF & Beasley, R (1990) Reduced selenium in asthmatic subjects in New Zealand. Thorax 45, 9599.
2.Rayman, MP (2000) The importance of selenium to human health. Lancet 356, 233241.
3.Niskar, AS, Paschal, DC, Kieszak, SM, Flegal, KM, Bowman, B, Gunter, EW, Pirkle, JL, Rubin, C, Sampson, EJ & McGeehin, M (2003) Serum selenium levels in the US population: Third National Health and Nutrition Examination Survey, 1988–1994. Biol Trace Elem Res 91, 110.
4.Vogt, TM, Ziegler, RG, Patterson, BH & Graubard, BI (2007) Racial differences in serum selenium concentration: analysis of US population data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 166, 280288.
5.World Health Organization (1987) Selenium. A Report of the International Programme on Chemical Safety. Environmental Health Criteria Series no. 58. Geneva: WHO.
6.Gao, S, Jin, Y, Hall, KS et al. (2007) Selenium level and cognitive function in rural elderly Chinese. Am J Epidemiol 165, 955965.
7.Stone, WL, Stewart, ME, Nicholas, C & Pavuluri, S (1986) Effects of dietary selenium and vitamin E on plasma lipoprotein cholesterol levels in male rats. Ann Nutr Metab 30, 94103.
8.Stone, WL, Scott, RL, Stewart, EM & Kheshti, A (1994) Lipoprotein alterations in the spontaneously hypertensive rat fed diets deficient in selenium and vitamin E. Proc Soc Exp Biol Med 206, 130137.
9.Sengupta, A, Carlson, BA, Hoffmann, VJ, Gladyshev, VN & Hatfield, DL (2008) Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun 365, 446452.
10.Li, M, Cao, J & Sun, S (1991) Micro-fluorometric determination of trace amount of selenium in blood, hair and milk powder. Chinese J Public Health 10, 306308.
11.Yang, M, Hendrie, HC, Hall, KS, Oluwole, OS, Hodes, ME & Sahota, A (1996) Improved procedure for eluting DNA from dried blood spots. Clin Chem 42, 11151116.
12.Hixson, JE & Vernier, DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31, 545548.
13.Chen, J, Campbell, TC, Li, J & Peto, R (1990) Diet, Lifestyle and Mortality in China. Oxford/Ithaca, NY/Beijing: Oxford University Press/Cornell University Press/People’s Publishing House.
14.Cao, J, Chen, S & Sun, S (1993) A comparison of methods for estimating large population dietary fluoride intake in coal burning high fluoride communities. J Hyg Res 22, 5254.
15.Zhai, F, Popkin, BM, Ma, L, Yu, W, Guo, X, Jin, S & Ge, K (1996) The evaluation of 24-hour individual dietary recall method in China. J Hyg Res 25, 5156.
16.Cao, J, Yan, B & Zhang, S (1996) Relations between heavy exposure of selenium-fluoride and human health. J Hyg Res 25, 287290.
17.He, L (2003) Summary for method and application of food frequency survey. J Foreign Med Sci: Hyg Sect 30, 368371.
18.van den Brandt, PA, Goldbohm, RA, van’t Veer, P, Bode, P, Hermus, RJ & Sturmans, F (1993) Predictors of toenail selenium levels in men and women. Cancer Epidemiol Biomarkers Prev 2, 107112.
19.Hunter, DJ, Morris, JS, Chute, CG, Kushner, E, Colditz, GA, Stampfer, MJ, Speizer, FE & Willett, WC (1990) Predictors of selenium concentration in human toenails. Am J Epidemiol 132, 114122.
20.Virtanen, SM, van’t Veer, P, Kok, F, Kardinaal, AF & Aro, A (1996) Predictors of adipose tissue tocopherol and toenail selenium levels in nine countries: the EURAMIC study. European Multicentre Case–Control Study on Antioxidants, Myocardial Infarction, and Cancer of the Breast. Eur J Clin Nutr 50, 599606.
21.Akbaraly, NT, Hininger-Favier, I, Carriere, I, Arnaud, J, Gourlet, V, Roussel, AM & Berr, C (2007) Plasma selenium over time and cognitive decline in the elderly. Epidemiology 18, 5258.
22.Mahley, RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622630.
23.Mahley, RW & Rall, SC Jr (2000) Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 1, 507537.
24.Weisgraber, KH & Mahley, RW (1996) Human apolipoprotein E: the Alzheimer’s disease connection. FASEB J 10, 14851494.
25.Talmud, PJ, Stephens, JW, Hawe, E, Demissie, S, Cupples, LA, Hurel, SJ, Humphries, SE & Ordovas, JM (2005) The significant increase in cardiovascular disease risk in APOEε4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4. Ann Hum Genet 69, 613622.
26.Smith, JD, Miyata, M, Poulin, SE, Neveux, LM & Craig, WY (1998) The relationship between apolipoprotein E and serum oxidation-related variables is apolipoprotein E phenotype dependent. Int J Clin Lab Res 28, 116121.
27.Jolivalt, C, Leininger-Muller, B, Bertrand, P, Herber, R, Christen, Y & Siest, G (2000) Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids. Free Radic Biol Med 28, 129140.
28.Miyata, M & Smith, JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nat Genet 14, 5561.
29.Shea, TB, Rogers, E, Ashline, D, Ortiz, D & Sheu, MS (2002) Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic Biol Med 33, 11151120.
30.Rosenblat, M & Aviram, M (1998) Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies. Free Radic Biol Med 24, 305317.
31.Mazur, A, Nassir, F, Gueux, E, Moundras, C, Bellanger, J, Grolier, P, Rock, E & Rayssiguier, Y (1996) Diets deficient in selenium and vitamin E affect plasma lipoprotein and apolipoprotein concentrations in the rat. Br J Nutr 76, 899907.
32.Aviram, M, Maor, I, Keidar, S, Hayek, T, Oiknine, J, Bar-El, Y, Adler, Z, Kertzman, V & Milo, S (1995) Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated. Biochem Biophys Res Commun 216, 501513.
33.Lavy, A, Brook, GJ, Dankner, G, Ben Amotz, A & Aviram, M (1991) Enhanced in vitro oxidation of plasma lipoproteins derived from hypercholesterolemic patients. Metabolism 40, 794799.
34.Keidar, S, Kaplan, M, Shapira, C, Brook, JG & Aviram, M (1994) Low density lipoprotein isolated from patients with essential hypertension exhibits increased propensity for oxidation and enhanced uptake by macrophages: a possible role for angiotensin II. Atherosclerosis 107, 7184.
35.Beaudeux, JL, Guillausseau, PJ, Peynet, J, Flourie, F, Assayag, M, Tielmans, D, Warnet, A & Rousselet, F (1995) Enhanced susceptibility of low-density lipoprotein to in vitro oxidation in type 1 and type 2 diabetic patients. Clin Chim Acta 239, 131141.
36.Luoma, PV, Nayha, S, Sikkila, K & Hassi, J (1995) High serum α-tocopherol, albumin, selenium and cholesterol, and low mortality from coronary heart disease in northern Finland. J Intern Med 237, 4954.
37.Zimmermann, C, Winnefeld, K, Streck, S, Roskos, M & Haberl, RL (2004) Antioxidant status in acute stroke patients and patients at stroke risk. Eur Neurol 51, 157161.
38.Chang, CY, Lai, YC, Cheng, TJ, Lau, MT & Hu, ML (1998) Plasma levels of antioxidant vitamins, selenium, total sulfhydryl groups and oxidative products in ischemic-stroke patients as compared to matched controls in Taiwan. Free Radic Res 28, 1524.
39.Virtamo, J, Valkeila, E, Alfthan, G, Punsar, S, Huttunen, JK & Karvonen, MJ (1985) Serum selenium and the risk of coronary heart disease and stroke. Am J Epidemiol 122, 276282.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed