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Folate and vitamin B12 status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam

  • Vu Thi Thu Hien (a1), Nguyen Thi Lam (a1), Nguyen Cong Khan (a1), Nguyen Tri Dung (a1), C Murray Skeaff (a2), Bernard J Venn (a2), Trevor Walmsley (a3), Peter M George (a3), Judy McLean (a4), Matthew R Brown (a4) and Timothy J Green (a2) (a4)...

Abstract

Objectives

To assess the folate and vitamin B12 status of a group of Vietnamese women of reproductive age and to estimate the rate of neural tube defects (NTD) based on red blood cell (RBC) folate concentrations.

Design and subjects

A representative sample of non-pregnant women (15–49 years) living in Hanoi City (n 244) and Hai Duong Province (n 245).

Measures

RBC folate, plasma vitamin B12 and plasma holo-transcobalamin (holoTC), a sensitive indicator of vitamin B12 status.

Results

Mean (95 % CI) concentrations of RBC folate, plasma B12 and plasma holoTC were 856 (837, 876) nmol/l, 494 (475, 513) pmol/l and 78 (74, 82) pmol/l, respectively. Only 3 % and 4 % of women had plasma B12 and holoTC concentrations indicative of deficiency. No woman had an RBC folate concentration indicative of deficiency (<317 nmol/l). Only 47 % of women had an RBC folate concentration ≥905 nmol/l. Accordingly, we predict the NTD rate in these regions of Vietnam to be 14·7 (14·2, 15·1) per 10 000 pregnancies.

Conclusion

There was no evidence of folate and vitamin B12 deficiency among this population of Vietnamese women. However, suboptimal folate status may be placing three out of five women at increased risk of NTD. Reductions in NTD rates are still possible and women would benefit from additional folic acid during the periconceptional period from either supplements or fortified foods.

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Copyright

Corresponding author

*Corresponding author: Email tim.green@ubc.ca

References

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1.MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338, 131137.
2.Berry, RJ, Li, Z, Erickson, JD et al. (1999) Prevention of neural-tube defects with folic acid in China. China–US Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 341, 14851490.
3.French, AE, Grant, R, Weitzman, S, Ray, JG, Vermeulen, MJ, Sung, L, Greenberg, M & Koren, G (2003) Folic acid food fortification is associated with a decline in neuroblastoma. Clin Pharmacol Ther 74, 288294.
4.Centers for Disease Control and Prevention (CDC) (2004) Spina bifida and anencephaly before and after folic acid mandate – United States, 1995–1996 and 1999–2000. MMWR Morb Mortal Wkly Rep 53, 362365.
5.Castilla, EE, Orioli, IM, Lopez-Camelo, JS, Dutra Mda, G & Nazer-Herrera, J (2003) Preliminary data on changes in neural tube defect prevalence rates after folic acid fortification in South America. Am J Med Genet A 123, 123128.
6.De Wals, P, Tairou, F, Van Allen, MI et al. (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357, 135142.
7.Daly, LE, Kirke, PN, Molloy, A, Weir, DG & Scott, JM (1995) Folate levels and neural tube defects. Implications for prevention. JAMA 274, 16981702.
8.Hao, L, Ma, J, Stampfer, MJ, Ren, A, Tian, Y, Tang, Y, Willett, WC & Li, Z (2003) Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr 133, 36303635.
9.Ray, JG & Blom, HJ (2003) Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM 96, 289295.
10.Ray, JG, Wyatt, PR, Thompson, MD, Vermeulen, MJ, Meier, C, Wong, PY, Farrell, SA & Cole, DE (2007) Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 18, 362366.
11.O’Broin, S & Kelleher, B (1992) Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol 45, 344347.
12.Gibson, RS (2005) Principles of Nutritional Assessment. Auckland: Oxford University Press.
13.Campbell, AK, Miller, JW, Green, R, Haan, MN & Allen, LH (2003) Plasma vitamin B-12 concentrations in an elderly Latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake. J Nutr 133, 27702776.
14.Puwastien, P (2002) Issues in the development and use of food composition databases. Public Health Nutr 5, 991999.
15.Tu, G, Ha, K, Bui, D, Huynh, N, Ha, D & Le, M (2000) Nutritive Composition Table of Vietnamese Foods. Hanoi: Medical Publishing House.
16.Green, TJ, Skeaff, CM, Venn, BJ et al. (2007) Red cell folate and predicted neural tube defect rate in three Asian cities. Asia Pac J Clin Nutr 16, 269273.
17. National Institute of Nutrition, Vietnam (2003) General Nutrition Survey 2000. Hanoi: Medical Publishing House.
18.Green, TJ, Skeaff, CM, Rockell, JE & Venn, BJ (2005) Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age. Asia Pac J Clin Nutr 14, 173178.
19.Ogle, BM, Johansson, M, Tuyet, HT & Johannesson, L (2001) Evaluation of the significance of dietary folate from wild vegetables in Vietnam. Asia Pac J Clin Nutr 10, 216221.
20.Hyun, TH & Tamura, T (2005) Trienzyme extraction in combination with microbiologic assay in food folate analysis: an updated review. Exp Biol Med (Maywood) 230, 444454.
21.Stabler, SP & Allen, RH (2004) Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 24, 299326.
22.Allen, LH (2004) Folate and vitamin B12 status in the Americas. Nutr Rev 62, S29S33.
23.Pathak, P, Kapil, U, Yajnik, CS, Kapoor, SK, Dwivedi, SN & Singh, R (2007) Iron, folate, and vitamin B12 stores among pregnant women in a rural area of Haryana State, India. Food Nutr Bull 28, 435438.
24.Yajnik, CS, Deshpande, SS, Lubree, HG, Naik, SS, Bhat, DS, Uradey, BS et al. (2006) Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians. J Assoc Physicians India 54, 775782.
25.Hao, L, Ma, J, Zhu, J, Stampfer, MJ, Tian, Y, Willett, WC et al. (2007) Vitamin B-12 deficiency is prevalent in 35- to 64-year-old Chinese adults. J Nutr 137, 12781285.
26.Scarlett, JD, Read, H & O’Dea, K (1992) Protein-bound cobalamin absorption declines in the elderly. Am J Hematol 39, 7983.
27.Gunter, EW, Bowman, BA, Caudill, SP, Twite, DB, Adams, MJ & Sampson, EJ (1996) Results of an international round robin for serum and whole-blood folate. Clin Chem 42, 16891694.
28.Thorpe, SJ, Heath, A, Blackmore, S, Lee, A, Hamilton, M, O’Broin, S, Nelson, BC & Pfeiffer, C (2007) International standard for serum vitamin B(12) and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B(12) and folate content. Clin Chem Lab Med 45, 380386.
29.Wald, NJ, Law, MR, Morris, JK & Wald, DS (2001) Quantifying the effect of folic acid. Lancet 358, 20692073.
30.Ogle, BM, Hung, PH & Tuyet, HT (2001) Significance of wild vegetables in micronutrient intakes of women in Vietnam: an analysis of food variety. Asia Pac J Clin Nutr 10, 2130.

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