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The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma

  • Alyson Haslam (a1), Sara Wagner Robb (a1), James R Hébert (a2) (a3), Hanwen Huang (a1), Michael D Wirth (a2) (a3), Nitin Shivappa (a2) (a3) and Mark H Ebell (a1)...

Abstract

Objective

The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person’s diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition.

Design

Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models.

Setting

Ten cancer screening centres across the USA.

Subjects

Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Results

Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women.

Conclusions

Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.

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Copyright

Corresponding author

* Corresponding author: Email alhaslam@uga.edu

References

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1. Esposito, K & Giugliano, D (2006) Diet and inflammation: a link to metabolic and cardiovascular diseases. Eur Heart J 27, 1520.
2. Reuter, S, Gupta, SC, Chaturvedi, MM et al. (2010) Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 49, 16031616.
3. Conner, EM & Grisham, MB (1996) Inflammation, free radicals, and antioxidants. Nutrition 12, 274277.
4. Garcia-Lafuente, A, Guillamon, E, Villares, A et al. (2009) Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 58, 537552.
5. Coussens, LM & Werb, Z (2002) Inflammation and cancer. Nature 420, 860867.
6. Shivappa, N, Steck, SE, Hurley, TG et al. (2014) A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Public Health Nutr 17, 18251833.
7. Wood, LG, Shivappa, N, Berthon, BS et al. (2015) Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma. Clin Exp Allergy 45, 177183.
8. Shivappa, N, Bosetti, C, Zucchetto, A et al. (2015) Dietary inflammatory index and risk of pancreatic cancer in an Italian case–control study. Br J Nutr 113, 292298.
9. Shivappa, N, Bosetti, C, Zucchetto, A et al. (2015) Association between dietary inflammatory index and prostate cancer among Italian men. Br J Nutr 113, 278283.
10. Tabung, FK, Steck, SE, Ma, Y et al. (2015) The association between dietary inflammatory index and risk of colorectal cancer among postmenopausal women: results from the Women’s Health Initiative. Cancer Causes Control 26, 399408.
11. Shivappa, N, Prizment, AE, Blair, CK et al. (2014) Dietary inflammatory index and risk of colorectal cancer in the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev 23, 23832392.
12. Zamora-Ros, R, Shivappa, N, Steck, SE et al. (2015) Dietary inflammatory index and inflammatory gene interactions in relation to colorectal cancer risk in the Bellvitge colorectal cancer case–control study. Genes Nutr 10, 447.
13. Stone, WL, Krishnan, K, Campbell, SE et al. (2014) The role of antioxidants and pro-oxidants in colon cancer. World J Gastrointest Oncol 6, 5566.
14. Terzić, J, Grivennikov, S, Karin, E et al. (2010) Inflammation and colon cancer. Gastroenterology 138, 21012114.
15. Gohagan, JK (2000) The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials 21, Suppl. 6, 249S250S.
16. Prorok, PC, Andriole, GL, Bresalier, RS et al. (2000) Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials 21, Suppl. 6, 273S309S.
17. Hayes, RB, Reding, D, Kopp, W et al. (2000) Etiologic and early marker studies in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials 21, Suppl. 6, 349S355S.
18. Weissfeld, JL, Schoen, RE, Pinsky, PF et al. (2005) Flexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial. J Natl Cancer Inst 97, 989997.
19. Subar, AF, Ziegler, RG, Thompson, FE et al. (2001) Is shorter always better? Relative importance of questionnaire length and cognitive ease on response rates and data quality for two dietary questionnaires. Am J Epidemiol 153, 404409.
20. Cavicchia, PP, Steck, SE, Hurley, TG et al. (2009) A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein. J Nutr 139, 23652372.
21. Shivappa, N, Steck, SE, Hurley, TG et al. (2014) Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr 17, 16891696.
22. Haskell, WL, Lee, I-M, Pate, RR et al. (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 116, 10811093.
23. Akaike, H (1974) A new look at the statistical model identification. Autom Control IEEE Trans 19, 716723.
24. Grivennikov, SI, Greten, FR & Karin, M (2010) Immunity, inflammation, and cancer. Cell 140, 883899.
25. Kim, S, Keku, TO, Martin, C et al. (2008) Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res 68, 323328.
26. Lopez-Garcia, E, Schulze, MB, Meigs, JB et al. (2005) Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr 135, 562566.
27. Hennig, B, Toborek, M & McClain, CJ (2001) High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. J Am Coll Nutr 20, 97105.
28. Walston, J, Xue, Q, Semba, R et al. (2006) Serum antioxidants, inflammation, and total mortality in older women. Am J Epidemiol 163, 1826.
29. Dixon, LB, Subar, AF, Peters, U et al. (2007) Adherence to the USDA Food Guide, DASH Eating Plan, and Mediterranean dietary pattern reduces risk of colorectal adenoma. J Nutr 137, 24432450.
30. Whalen, KA, McCullough, M, Flanders, WD et al. (2014) Paleolithic and Mediterranean diet pattern scores and risk of incident, sporadic colorectal adenomas. Am J Epidemiol 180, 10881097.
31. Chrysohoou, C, Panagiotakos, DB, Pitsavos, C et al. (2004) Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA Study. J Am Coll Cardiol 44, 152158.
32. Ford, E, Mokdad, A & Liu, S (2005) Healthy Eating Index and C-reactive protein concentration: findings from the National Health and Nutrition Examination Survey III, 1988–1994. Eur J Clin Nutr 59, 278283.
33. Wirth, MD, Shivappa, N, Steck, SE et al. (2015) The dietary inflammatory index is associated with colorectal cancer in the National Institutes of Health–American Association of Retired Persons Diet and Health Study. Br J Nutr 113, 18191827.
34. Kim, S-E, Paik, HY, Yoon, H et al. (2015) Sex- and gender-specific disparities in colorectal cancer risk. World J Gastroenterol 21, 51675175.
35. Reedy, J, Wirfält, E, Flood, A et al. (2010) Comparing 3 dietary pattern methods – cluster analysis, factor analysis, and index analysis – with colorectal cancer risk: the NIH–AARP Diet and Health Study. Am J Epidemiol 171, 479487.
36. Hebert, JR, Ma, Y, Clemow, L et al. (1997) Gender differences in social desirability and social approval bias in dietary self-report. Am J Epidemiol 146, 10461055.
37. Robertson, DJ, Sandler, RS, Haile, R et al. (2005) Fat, fiber, meat and the risk of colorectal adenomas. Am J Gastroenterol 100, 27892795.
38. Randi, G, Edefonti, V, Ferraroni, M et al. (2010) Dietary patterns and the risk of colorectal cancer and adenomas. Nutr Rev 68, 389408.
39. Reedy, J, Mitrou, PN, Krebs-Smith, et al. (2008) Index-based dietary patterns and risk of colorectal cancer the NIH–AARP Diet and Health Study. Am J Epidemiol 168, 3848.

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