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Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and elderly adults

  • Mian-Li Xiao (a1), Jie-Sheng Lin (a1), Yi-Hong Li (a1), Meng Liu (a1), Yun-Yang Deng (a1), Chang-Yi Wang (a2) and Yu-Ming Chen (a1)...

Abstract

Objective:

Previous studies have shown that the Dietary Approaches to Stop Hypertension (DASH) diet might contribute to managing risk factors of non-alcoholic fatty liver disease (NAFLD), but evidence is limited. We examined the association of DASH diet score (DASH-DS) with NAFLD, as well as the intermediary effects of serum retinol-binding protein-4 (RBP4), serum high-sensitivity C-reactive protein (hs-CRP), serum TAG, homeostasis model assessment of insulin resistance (HOMA-IR) and BMI.

Design:

We performed a cross-sectional analysis of a population-based cohort study. Dietary data and lifestyle factors were assessed by face-to-face interviews and the DASH-DS was then calculated. We assessed serum RBP4, hs-CRP and TAG and calculated HOMA-IR. The presence and degree of NAFLD were determined by abdominal sonography.

Setting:

Guangzhou, China.

Participants:

Guangzhou Nutrition and Health Study participants, aged 40–75 years at baseline (n 3051).

Results:

After adjusting for potential covariates, we found an inverse association between DASH-DS and the presence of NAFLD (Ptrend = 0·009). The OR (95 % CI) of NAFLD for quintiles 2–5 were 0·78 (0·62, 0·98), 0·74 (0·59, 0·94), 0·69 (0·55, 0·86) and 0·77 (0·61, 0·97), respectively. Path analyses indicated that a higher DASH-DS was associated with lower serum RBP4, hs-CRP, TAG, HOMA-IR and BMI, which were positively associated with the degree of NAFLD.

Conclusions:

Adherence to the DASH diet was independently associated with a marked lower prevalence of NAFLD in Chinese adults, especially in women and those without abdominal obesity, and might be mediated by reducing RBP4, hs-CRP, TAG, HOMA-IR and BMI.

Copyright

Corresponding author

*Corresponding authors: Email chenyum@mail.sysu.edu.cn; wangchangyi2002@163.com

Footnotes

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Mian-Li Xiao and Jie-Sheng Lin contributed equally to this article.

Footnotes

References

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Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower presence of non-alcoholic fatty liver disease in middle-aged and elderly adults

  • Mian-Li Xiao (a1), Jie-Sheng Lin (a1), Yi-Hong Li (a1), Meng Liu (a1), Yun-Yang Deng (a1), Chang-Yi Wang (a2) and Yu-Ming Chen (a1)...

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