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25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES)

  • Ga Eun Nam (a1), Do Hoon Kim (a1), Kyung Hwan Cho (a1), Yong Gyu Park (a2), Kyung Do Han (a2), Seon Mee Kim (a1), Seung Hwan Lee (a1), Byung Joon Ko (a1) and Min Ji Kim (a1)...

Abstract

Objective

Vitamin D insufficiency is known to be related to cardiometabolic disorders; however, the associations among serum 25-hydroxyvitamin D (25(OH)D) concentration and metabolic syndrome and cardiometabolic risk factors in children and adolescents have not yet been clearly delineated. For this reason, we investigated the relationship among serum 25(OH)D concentration and metabolic syndrome and cardiometabolic risk factors among Korean adolescents.

Design

We performed a cross-sectional analysis and used hierarchical multivariate logistic regression analysis models to adjust for confounding variables.

Setting

We used the data gathered during the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES).

Subjects

Our subjects included 1504 Korean adolescents aged 12–18 years who participated in the KNHANES.

Results

Vitamin D insufficiency, defined as 25(OH)D concentration <50 nmol/l, was found in 75·3 % of Korean adolescents and was associated with an increased risk of the prevalence of metabolic syndrome. Waist circumference and BMI were the most closely correlated cardiometabolic components of metabolic syndrome according to serum 25(OH)D status, but no significant relationship was found between serum 25(OH)D concentration and insulin resistance or for the risks for high blood pressure, hyperglycaemia, reduced HDL-cholesterol or hypertriacylglycerolaemia, with or without adjustment for confounding variables.

Conclusions

Low serum 25(OH)D concentration appears to be associated with several cardiometabolic risk factors and an increased risk of the prevalence of metabolic syndrome in Korean adolescents.

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Copyright

Corresponding author

*Corresponding author: Email chokh@korea.ac.kr

References

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