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Understanding the relative contributions of direct environmental effects and passive genotype–environment correlations in the association between familial risk factors and child disruptive behavior disorders

  • M. A. Bornovalova (a1), J. R. Cummings (a1), E. Hunt (a1), R. Blazei (a2), S. Malone (a2) and W. G. Iacono (a2)...



Previous work reports an association between familial risk factors stemming from parental characteristics and offspring disruptive behavior disorders (DBDs). This association may reflect (a) the direct effects of familial environment and (b) a passive gene–environment correlation (r GE), wherein the parents provide both the genes and the environment. The current study examined the contributions of direct environmental influences and passive r GE by comparing the effects of familial risk factors on child DBDs in genetically related (biological) and non-related (adoptive) families.


Participants were 402 adoptive and 204 biological families. Familial environment was defined as maternal and paternal maladaptive parenting and antisociality, marital conflict and divorce; offspring DBDs included attention deficit hyperactivity disorder (ADHD), conduct disorder (CD) and oppositional defiant disorder (ODD). Mixed-level regressions estimated the main effects of familial environment, adoption status and the familial environment by adoption status interaction term, which tested for the presence of passive r GE.


There was a main effect of maternal and paternal maladaptive parenting and marital discord on child DBDs, indicating a direct environmental effect. There was no direct environmental effect of maternal or paternal antisociality, but maternal and paternal antisociality had stronger associations with child DBDs in biological families than adoptive families, indicating the presence of a passive r GE.


Many familial risk factors affected children equally across genetically related and non-related families, providing evidence for direct environmental effects. The relationship of parental antisociality and offspring DBDs was best explained by a passive r GE, where a general vulnerability toward externalizing psychopathology is passed down by the parents to the children.


Corresponding author

* Address for correspondence: Dr M. A. Bornovalova, Department of Psychology and Department of Mental Health Law and Policy, University of South Florida, 4202 East Fowler Avenue, PCD4118G, Tampa, FL 33620, USA. (Email:


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Blazei, RW, Iacono, WG, McGue, M (2008). Father-child transmission of antisocial behavior: the moderating role of father's presence in the home. Journal of the American Academy of Child & Adolescent Psychiatry 47, 406415.
Bornovalova, MA (2010). Familial transmission and heritability of childhood disruptive disorders. American Journal of Psychiatry 167, 14141414.
Bornovalova, MA, Blazei, R, Malone, SH, McGue, M, Iacono, WG (2012). Disentangling the relative contribution of parental antisociality and family discord to child disruptive disorders. Personality Disorders: Theory, Research, and Treatment. Published online: 13 August 2012 . doi:10.1037/a0028607.
Braungartrieker, J, Rende, RD, Plomin, R, Defries, JC, Fulker, DW (1995). Genetic mediation of longitudinal associations between family environment and childhood behavior problems. Development and Psychopathology 7, 233245.
Burt, S, Barnes, AR, McGue, M, Iacono, WG (2008). Parental divorce and adolescent delinquency: ruling out the impact of common genes. Developmental Psychology 44, 16681677.
Burt, SA (2009). Rethinking environmental contributions to child and adolescent psychopathology: a meta-analysis of shared environmental influences. Psychological Bulletin 135, 608637.
Burt, SA, Krueger, RF, McGue, M, Iacono, WG (2003). Parent-child conflict and the comorbidity among childhood externalizing disorders. Archives of General Psychiatry 60, 505513.
Burt, SA, McGue, M, Krueger, RF, Iacono, WG (2007). Environmental contributions to adolescent delinquency: a fresh look at the shared environment. Journal of Abnormal Child Psychology 35, 787800.
Caspi, A, Moffitt, TE, Morgan, J, Rutter, M, Taylor, A, Arseneault, L, Tully, L, Jacobs, C, Kim-Cohen, J, Polo-Tomas, M (2004). Maternal expressed emotion predicts children's antisocial behavior problems: using monozygotic-twin differences to identify environmental effects on behavioral development. Developmental Psychology 40, 149161.
Denham, SA, Workman, E, Cole, PM, Weissbrod, C, Kendziora, KT, Zahn-Waxler, C (2000). Prediction of externalizing behavior problems from early to middle childhood: the role of parental socialization and emotion expression. Development and Psychopathology 12, 2345.
D'Onofrio, BM, Turkheimer, E, Emery, RE, Maes, HH, Silberg, JL, Eaves, LJ (2007). A Children of Twins Study of parental divorce and offspring psychopathology. Journal of Child Psychology and Psychiatry 48, 667675.
D'Onofrio, BM, Turkheimer, E, Emery, RE, Slutske, WS, Heath, AC, Madden, PAF (2005). A genetically informed study of marital instability and its association with offspring psychopathology. Journal of Abnormal Psychology 114, 570586.
Dunn, J, Plomin, R (1986). Determinants of maternal behavior towards 3-year-old siblings. British Journal of Developmental Psychology 4, 127137.
Dunn, JF, Plomin, R, Daniels, D (1986). Consistency and change in mothers' behavior toward young siblings. Child Development 57, 348356.
Dunn, JF, Plomin, R, Nettles, M (1985). Consistency of mothers' behavior toward infant siblings. Developmental Psychology 21, 11881195.
Elkins, IJ, King, SM, McGue, M, Iacono, WG (2006). Personality traits and the development of nicotine, alcohol, and illicit drug disorders: prospective links from adolescence to young adulthood. Journal of Abnormal Psychology 115, 2639.
Elkins, IJ, McGue, M, Iacono, WG (1997). Genetic and environmental influences on parent-son relationships: evidence for increasing genetic influence during adolescence. Developmental Psychology 33, 351363.
Gartstein, MA, Fagot, B (2003). Parental dysphoria, related family/parenting variables, and child externalizing behaviors: effortful control as a potential mediator. Journal of Applied Developmental Psychology 24, 143177.
Hanley, JA, Negassa, A, Edwardes, MDD, Forrester, JE (2003). Statistical analysis of correlated data using generalized estimating equations: an orientation. American Journal of Epidemiology 157, 364375.
Harden, KP, Turkheimer, E, Emery, RE, D'Onofrio, BM, Slutske, WS, Heath, AC, Martin, NG (2007). Marital conflict and conduct problems in children of twins. Child Development 78, 118.
Herndon, RW, Iacono, WG (2005). Psychiatric disorder in the children of antisocial parents. Psychological Medicine 35, 18151824.
Jaffee, SR, Price, TS (2008). Genotype-environment correlations: implications for determining the relationship between environmental exposures and psychiatric illness. Psychiatry 7, 496499.
Johnson, JG, Cohen, P, Kasen, S, Smailes, E, Brook, JS (2001). Association of maladaptive parental behavior with psychiatric disorder among parents and their offspring. Archives of General Psychiatry 58, 453460.
Kendler, KS, Baker, JH (2007). Genetic influences on measures of the environment: a systematic review. Psychological Medicine 37, 615626.
Kessler, RC, Merikangas, KR, Berglund, P, Eaton, WW, Koretz, DS, Walters, EE (2003). Mild disorders should not be eliminated from the DSM-V. Archives of General Psychiatry 60, 11171122.
Keyes, M, Legrand, LN, Iacono, WG, McGue, M (2008). Parental smoking and adolescent problem behavior: an adoption study of general and specific effects. American Journal of Psychiatry 165, 13381344.
King, SM, Keyes, M, Malone, SM, Elkins, I, Legrand, LN, Iacono, WG, McGue, M (2009). Parental alcohol dependence and the transmission of adolescent behavioral disinhibition: a study of adoptive and non-adoptive families. Addiction 104, 578586.
Loeber, R, Stouthamer-Loeber, M (1986). Family factors as correlates and predictors of juvenile conduct problems and delinquency. In Crime and Justice, vol. 7 (ed. Tonry, M. and Morris, N.), pp. 219339. University of Chicago Press: Chicago, IL.
McGue, M, Keyes, M, Sharma, A, Elkins, I, Legrand, L, Johnson, W, Iacono, WG (2007). The environments of adopted and non-adopted youth: evidence on range restriction from the Sibling Interaction and Behavior Study (SIBS). Behavior Genetic 37, 449462.
McGue, M, Lykken, DT (1992). Genetic influence on risk of divorce. Psychological Science 3, 368373.
McGue, M, Sharma, A, Benson, P (1996). The effect of common rearing on adolescent adjustment: evidence from a US adoption cohort. Developmental Psychology 32, 604613.
Narusyte, J, Neiderhiser, JM, Andershed, AK, D'Onofrio, BM, Reiss, D, Spotts, E, Ganiban, J, Lichtenstein, P (2011). Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation. Journal of Abnormal Psychology 120, 365376.
Neiderhiser, JA, Reiss, D, Lichtenstein, P, Spotts, EL, Ganiban, J (2007). Father-adolescent relationships and the role of genotype-environment correlation. Journal of Family Psychology 21, 560571.
Neiderhiser, JM, Reiss, D, Pedersen, NL, Lichtenstein, P, Spotts, EL, Hansson, K (2004). Genetic and environmental influences on mothering of adolescents: a comparison of two samples. Developmental Psychology 40, 335351.
O'Connor, TG, Caspi, A, DeFries, JC, Plomin, R (2000). Are associations between parental divorce and children's adjustment genetically mediated? An adoption study. Developmental Psychology 36, 429437.
Pickles, A, Rowe, R, Simonoff, E, Foley, D, Rutter, M, Silberg, J (2001). Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significance. British Journal of Psychiatry 179, 230235.
Pike, A, McGuire, S, Hetherington, EM, Reiss, D, Plomin, R (1996). Family environment and adolescent depressive symptoms and antisocial behavior: a multivariate genetic analysis. Developmental Psychology 32, 590603.
Plomin, R (1994). Genetics and Experience: The Developmental Interplay Between Nature and Nurture. Sage: Newbury Park, CA.
Reiss, D, Neiderhiser, JM, Hetherington, EM, Plomin, R (2000). The Relationship Code: Deciphering Genetic and Social Influences on Adolescent Development. Harvard University Press: Cambridge, MA.
Rende, RD, Slomkowski, CL, Stocker, C, Fulker, DW, Plomin, R (1992). Genetic and environmental influences on maternal and sibling interaction in middle childhood: a sibling adoption study. Developmental Psychology 28, 484490.
Rhee, SH, Waldman, ID (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin 128, 490529.
Rothbaum, F, Weisz, J (1994). Parental converging and child externalizing behavior in nonclinical samples: a meta-analysis. Psychological Bulletin 116, 5574.
Silberg, JL, Maes, H, Eaves, LJ (2012). Unraveling the effect of genes and environment in the transmission of parental antisocial behavior to children's conduct disturbance, depression and hyperactivity. Journal of Child Psychology and Psychiatry 53, 668677.
Spanier, GB (1976). Measuring dyadic adjustment: new scales for assessing the quality of marriage and similar dyads. Journal of Marriage and the Family 38, 1528.
Spitzer, RL, Williams, JBW, Gibbons, M, First, MB (1987). Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II). Biometrics Research Division, New York State Psychiatric Institute: New York, NY.
Spotts, EL, Neiderhiser, JM, Towers, H, Hansson, K, Lichtenstein, P, Cederblad, M, Pederson, NL, Reiss, D (2004). Genetic and environmental influences on marital relationships. Journal of Family Psychology 18, 107119.
Spotts, EL, Prescott, C, Kendler, K (2006). Examining the origins of gender differences in marital quality: a behavior genetic analysis. Journal of Family Psychology 20, 605613.
Stanger, C, Dumenci, L, Kamon, J, Burstein, M (2004). Parenting and children's externalizing problems in substance-abusing families. Journal of Clinical Child and Adolescent Psychology 33, 590600.
Stormshak, EA, Bierman, KL, McMahon, RJ, Lengua, LJ (2000). Parenting practices and child disruptive behavior problems in early elementary school. Journal of Clinical Child Psychology 29, 1729.
Welner, Z, Reich, W, Herjanic, B, Jung, K, Amado, H (1987). Reliability, validity, and parent-child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA). Journal of the American Academy of Child and Adolescent Psychiatry 26, 649653.


Understanding the relative contributions of direct environmental effects and passive genotype–environment correlations in the association between familial risk factors and child disruptive behavior disorders

  • M. A. Bornovalova (a1), J. R. Cummings (a1), E. Hunt (a1), R. Blazei (a2), S. Malone (a2) and W. G. Iacono (a2)...


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