Agren, H. (1980). Symptoms patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid. II. Suicide. Psychiatric Research 3, 225–236.
Andrews, C. D., Fernando, J. C. R. & Curzon, G. (1982). Differential involvement of dopamine-containing tracts in 5-hydroxytryptamine – dependent behaviours caused by amphetamine in large doses. Neuropharmacology 21, 63–68.
Antelman, S. M., Szechtman, H., Chin, P. & Fisher, A. E. (1975). Tail pinch-induced eating, gnawing and licking behaviour in rats: dependence on the nigrostriatal dopamine system. Brain Research 99, 319–337.
Aprison, M. H., Takahashi, R. & Tachiki, K. (1978). Hypersensitive serotonergic receptors involved in clinical depression – a theory. In Neuropharmacology and Behaviour (ed. Haber, B. and Aprison, M. H.), pp. 23–53. Plenum: New York.
Åsberg, M., Traskman, L. & Thoren, P. (1976). 5HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry 33, 1193–1197.
Banki, C. M., Molnar, G. & Vojnik, M. (1981). Cerebrospinal fluid amine metabolites, tryptophan and clinical parameters in depression. Journal of Affective Disease 3, 91–99.
Beaudet, A. & Descarries, L. (1978). The monoamine innervation of rat cerebral cortex: synaptic and non-synaptic axon terminals. Neuroscience 3, 851–860.
Berger, P. A., Faull, K. F., Kilkowski, J., Anderson, P. J., Kraemer, H., Davis, K. L. & Barchas, J. D. (1980). CSF monoamine metabolites in depression and schizophrenia. American Journal of Psychiatry 137, 174–180.
Birkmayer, W. & Riederer, P. (1975). Biochemical post-mortem findings in depressed patients. Journal of Neural Transmission 37. 95–109.
Brodie, B. B. & Shore, P. H. (1957). A concept for a role of serotonin and norepinephrine as chemical mediators in the brain. Annals of the New York Academy of Sciences 66, 631–642.
Chiodo, L. A. & Antelman, S. M. (1980). Electroconvulsive shock: progressive dopamine autoreceptor subsensitivity independent of repeated treatment. Science 210, 799–801.
Coppen, A., Shaw, D. M. & Farrell, J. P. (1963). Potentiation of the anti-depressive effect of a monoamine-oxidase inhibitor by tryptophan. Lancet i, 79–81.
Crawley, J. N., Maas, J. W. & Roth, R. H. (1980). Evidence against specificity of electrical stimulation of the nucleus locus coeruleus in activating the sympathetic nervous system in the rat. Brain Research 183, 301–311.
Curzon, G., Kantamaneni, B. D., Lader, M. H. & Greenwood, M. H. (1979). Tryptophan disposition in psychiatric patients. Psychological Medicine 9, 457–463.
Curzon, G., Fernando, J. C. R. & Lees, A. J. (1980 a). Behaviour provoked by simultaneous release of dopamine and serotonin: possible relevance to psychotic behaviour. In Enzymes and Neurotransmitters in Mental Disease (ed. Usdin, E., Sourkes, T. L. and Youdim, M. B. H.), pp. 411–430. Wiley: New York.
Curzon, G., Kantamaneni, B. D., Van Boxel, P., Gillman, P. K., Bartlett, J. R. & Bridges, P. K. (1980 b). Substances related to 5-hydroxytryptamine in plasma, and in lumbar and ventricular fluids of psychiatric patients. Acta psychiatrica scandinavica, Supplement 280, 3–19.
Fillion, G. & Fillion, M. P. (1981). Modulation of affinity of postsynaptic serotonin receptors by antidepressant drugs. Nature 292, 349–351.
Fuller, R. W. & Molloy, B. B. (1974). Recent studies with 4-chloroamphetamine and some analogues. Advances in Biochemical Psychopharmacology 10, 195–205.
Fuxe, K., Ogren, S. O., Agnati, L. F., Eneroth, P., Holm, A. C. & Andersson, K. (1981). Long term treatment with zimelidine leads to a reduction in 5-hydroxytryptamine neurotransmission within the central nervous system of the mouse and rat. Neuroscience Letters 21, 57–62.
Gillman, P. K., Bartlett, J. R., Bridges, P. K., Hunt, A., Patel, A. J., Kantamaneni, B. D. & Curzon, G. (1981). Indolic substances in plasma, cerebrospinal fluid and frontal cortex of human subjects infused with saline or tryptophan. Journal of Neurochemistry 37, 410–417.
Goodwin, F. K. & Post, R. M. (1975). Studies of amine metabolites in affective illness and schizophrenia: a comparative analysis. Research Publications of the Association for Research on Nervous and Mental Disease 54, 299–332.
Green, A. R. (1980). Changes in monoamine function in rats after electroconvulsive shocks: possible mechanisms involved and their relevance to ECT. In The Biochemistry of Psychiatric Disturbances (ed. Curzon, G.), pp. 35–52. Wiley: New York.
Green, A. R. & Deakin, J. F. W. (1980). Brain noradrenaline depletion prevents ECS-induced enhancement of serotonin and dopamine mediated behaviour. Nature 285, 232–233.
Hall, H. & Ogren, S. O. (1981). Effects of antidepressant drugs on different receptors in the brain. European Journal of Pharmacology 70, 393–407.
Hallberg, H., Almgren, O. & Svensson, T. H. (1981). Increased brain serotonergic and noradrenergic activity after repeated systemic administration of the beta-2 adrenoceptor agonist salbutamol, a putative antidepressant drug. Psychopharmacology 73, 201–204.
Handley, S. L., Dunn, R. L., Waldron, G. & Baker, J. M. (1980). Tryptophan, cortisol and puerperal mood. British Journal of Psychiatry 136, 498–508.
Hokfelt, T., Johansson, O., Ljungdahl, A., Lundberg, J. M. & Schultzberg, M. (1980). Peptidergic neurones. Nature 284, 515–521.
Huet, P. M., Pomier-Layrargues, G., Duguay, L. & DuSouich, P. (1981). Blood–brain transport of tryptophan and phenylalanine: effect of portacaval shunt in dogs. American Journal of Physiology 241, G163–169.
Hwang, E. C., Magnussen, I. & Van Woert, M. (1980). Effects of chronic fluoxetine administration on serotonin metabolism. Research Communications in Chemical Pathology and Pharmacology 29, 79–98.
Jones, R. S. G. (1980). Enhancement of 5-hydroxytryptamine-induced behavioural effects following chronic administration of antidepressant drugs. Psychopharmacology 69, 307–311.
Jones, R. S. G. (1981). In vivo pharmacological studies on the interactions between tryptamine and 5-hydroxytryptamine. British Journal of Pharmacology 73, 485–493.
Jouvet, M. (1977). Neuropharmacology of the sleep–waking cycle. In Handbook of Psychopharmacology, vol. 8 (ed. Iversen, L. L., Iversen, S. D. and Snyder, S. H.), pp. 233–293. Plenum: New York.
Karoum, F., Wyatt, R. & Costa, E. (1974). Estimation of the contribution of peripheral and central noradrenergic neurones to urinary 3-methoxy-4-hydroxy-phenylglycol in the rat. Neuropharmacology 13, 165–176.
Keller, K. J., Cascio, C. S., Butler, J. A. & Kurtzke, R. N. (1981). Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. European Journal of Pharmacology 69, 515–518.
Kelly, P. H. (1977). Drug induced motor behaviour. In Handbook of Psychopharmacology, vol. 8 (ed. Iversen, L. L., Iversen, S. D. and Snyder, S. H.), pp. 295–331. Plenum: New York.
Kennett, G. A. & Joseph, M. H. (1981). The functional importance of increased brain tryptophan in the serotonergic response to restraint stress. Neuropharmacology 20, 39–43.
Lebrecht, U. & Nowak, J. Z. (1980). Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain. II: Behavioural studies. Neuropharmacology 19, 1055–1061.
Lindberg, D., Ahlfors, U. G., Dencker, S. J., Fruensgaard, K., Hansten, S., Jensen, K., Ose, E. & Pinkanen, T. A. (1979). Symptom reduction in depression after treatment with L-tryptophan or imipramine: item analysis of Hamilton rating scale for depression. Acta psychiatrica scandinavica 60, 287–294.
Lloyd, K. G., Farley, I. J., Deck, J. H. & Hornykiewicz, O. (1974). Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brain stem of suicide victims and control patients. Advances in Biochemical Psychopharmacology 11, 387–397.
Maitre, L., Waldmeier, P. C., Greengrass, P. M., Jaeckel, J., Sedlacek, S. & Delini-Stula, A. (1975). Maprotiline – its position as an anti-depressant in the light of recent neuropharmacological and neurobiochemical findings. Journal of International Medical Research 3, Supplement 2, 2–15.
Maj, T., Gancarczyk, L., Gorszczyk, E. & Rawlow, A. (1977). Doxepin as a blocker of central serotonin receptors. Pharmako-psychiatric Neuro-Psychopharmakologie 10, 318–324.
Marsden, C. A. & Curzon, G. (1976). Studies on the behavioural effects of tryptophan and p-chlorophenylalanine. Neuropharmacology 15. 165–171.
Marsden, C. A. & Curzon, G. (1979). The role of tryptamine in the behavioural effects of tranylcypromine + L-tryptophan. Neuropharmacology 18, 159–164.
Moller, S. E., Kirk, L. & Honore, P. (1979). Free and total plasma tryptophan in endogenous depression. Journal of Affective Disorders 1, 69–76.
Moller, S. E., Kirk, L. & Honore, P. (1980). Relationship between plasma ratio of tryptophan to competing amino acids and the response to L-tryptophan treatment in endogeneously depressed patients. Journal of Affective Diseases 2, 47–59.
Ogren, S. O., Fuxe, K., Agnati, L. F., Gustafsson, J. A., Jonsson, G. & Holm, A. C. (1979). Re-evaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5HT systems by antidepressant drugs. Journal of Neural Transmission 46, 85–103.
Ogren, S. O., Fuxe, K. & Agnati, L. F. (1982). On the mechanism of action of antidepressant drugs: changes in 5HT receptor mechanisms leading to stabilization of 5HT neurotransmission. Trends in Neurosciences. (In the press.)
Osborne, N. N. (1981). Communication between neurones: current concepts. Neurochemistry International 3, 3–16.
Post, R. M., Kotin, J., Goodwin, F. K. & Gordon, E. K. (1973). Psychomotor activity and cerebrospinal fluid amine metabolites in affective illness. American Journal of Psychiatry 130, 67–72.
Post, R. M., Gerner, R. H., Carmon, J. S., Gillin, J. C., Jimerson, D. C., Goodwin, F. K. & Bunney, W. E. (1978). Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment HVA to anti-depressant response. Archives of General Psychiatry 35, 609–615.
Post, R. M., Jimerson, D. C., Bunney, W. E. & Goodwin, F. K. (1980). Dopamine and mania: behavioural and biochemical effects of the dopamine receptor blocker pimozide. Psychopharmacology 67, 297–305.
Rosenthal, N. E., Davenport, Y., Cowdry, R. W., Webster, M. & Goodwin, F. K. (1980). Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Research 2, 113–119.
Ross, S. B., Hall, H., Renyi, A. L. & Westerlund, D. (1981). Effects of zimelidine on serotonergic and noradrenergic neurons after repeated administration in the rat. Psychopharmacology 72, 219–225.
Schildkraut, J. J. (1973). Norepinephrine metabolism in the pathophysiology and classification of depressive and manic disorders. In Psychopathology and Psychopharmacology (ed. Cole, J. O., Freedman, A. M. and Friedhoff, A. J.), pp. 231–249. Johns Hopkins University Press: Baltimore.
Sedvall, G., Fyro, B., Gallberg, B., Nyback, H., Wiesel, F. A. & Wode-Helgodt, B. (1980). Relationship in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity. British Journal of Psychiatry 136, 366–374.
Serra, G., Argiolas, A., Fadda, F., Melis, M. R. & Gessa, G. L. (1981). Repeated electroconvulsive shock prevents the sedative effect of small doses of apomorphine. Psychopharmacology 73, 194–196.
Shaw, D. M., Tidmarsh, S. F. & Karagji, B. M. (1980). Tryptophan, affective disorder and stress. Journal of Affective Disorders 2, 321–325.
Shopsin, B., Friedman, E. & Gershon, S. (1976). p-Chlorophenylalanine reversal of tranylcypromine effects in depressed patients. Archives of General Psychiatry 33, 811–819.
Stein, G., Milton, F., Bebbington, P., Wood, K. & Coppen, A. (1976). Relationship between mood disturbances and free and total plasma tryptophan in postpartum women. British Medical Journal ii, 457.
Sulser, F. (1978). Functional aspects of the norepinephrine receptor coupled adenylate cyclase system in the limbic forebrain and its modification by drugs which precipitate or alleviate depression: molecular approaches to an understanding of affective disorders. Pharmakopsychiatrie Neuro-Psychopharmakologie 11, 43–52.
Swade, C. & Coppen, A. (1980). Seasonal variations in biochemical factors related to depressive illness. Journal of Affective Disorders 2, 249–255.
Van Praag, H. M. (1977). New evidence of serotonin deficient depression. Neuropsychobiology 3, 56–63.
Van Praag, H. M. & De Haan, S. (1980). Depression vulnerability and 5-hydroxytryptophan prophylaxis. Psychiatry Research 3, 75–83.
Van Praag, H. M., Kits, T. P., Schut, T. & Dijkstra, P. (1969). An attempt at indirect evaluation of the noradrenaline hypothesis. Results of a pilot study of the antidepressive qualities of p-chloro-N-methylamphetamine. Behavioural Neuropsychiatry 1, 17–24.
Van Scheyen, J. D., Van Praag, H. M. & Korf, J. (1977). Controlled study comparing nomifensine and clomipramine in unipolar depression using the probenecid technique. British Journal of Clinical Pharmacology 4, 179S–184S.
Waldbillig, R. J., Bartness, T. J. & Stanley, B. G. (1981). Disproportionate increases in locomotor activity in response to hormonal and photic stimulation following regional neurochemical depletion of serotonin. Brain Research 217, 79–91.
Waldmeier, P. C. (1981). Noradrenergic transmission in depression: under or overfunction? Pharmacopsychiatria 14, 39.
Wålinder, J., Skott, A., Carlsson, A., Nagy, A. & Roos, B. E. (1976). Potentiation of the antidepressant action of clomipramine by tryptophan. Archives of General Psychiatry 33, 1384–1389.
Wong, D. T. & Bymaster, F. P. (1981). Subsensitivity of serotonin receptors after long term treatment of rats with fluoxetine. Research Communications in Chemical Pathology and Pharmacology 32, 41–51.