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The structure of genetic and environmental influences on normative personality, abnormal personality traits, and personality disorder symptoms

  • Kenneth S. Kendler (a1) (a2) (a3), Steven H. Aggen (a1) (a2), Nathan Gillespie (a1) (a2), Robert F. Krueger (a4), Nikolai Czajkowski (a5) (a6), Eivind Ystrom (a5) (a6) and T. Reichborn-Kjennerud (a5) (a7)...

Abstract

Background

Can the structure of genetic and environmental influences on normative personality traits (NPTs), abnormal personality traits (APTs), and DSM-IV criteria for personality disorders (PD) fit a high or low congruence model positing, respectively, close or more limited etiologic continuity?

Method

Exploratory factor analysis was applied to transformed correlation matrices from Cholesky twin decompositions obtained in OpenMx. In 2801 adult twins from the Norwegian Institute of Public Health Twin Panel, NPTs and APTs were assessed by self-report using the Big Five Inventory (BFI) and PID-5-Norwegian Brief Form (PID-5-NBF), respectively. PDs were assessed at interview using the Structured Interview for DSM-IV Personality (SIDP-IV).

Results

The best model yielded three genetic and three unique environmental factors. Genetic factors were dominated, respectively, by (i) high loadings on nearly all PDs and NPT/APT neuroticism and compulsivity, (ii) negative loadings on NPT agreeableness/conscientiousness and positive loadings on APT/PD measures of antisocial traits, and (iii) negative loadings on NPT extraversion and histrionic PD, and positive loadings on APT detachment and schizoid/avoidant PD. Unique environmental factors were dominated, by (i) high loadings on all PDs, (ii) high loadings on all APT dimensions and NPT neuroticism, and (iii) negative loadings on NPT extraversion and positive loadings on NPT detachment/avoidant PD.

Conclusions

Two genetic and one environmental common factor were consistent with a high congruence model while one genetic and two environmental factors were more supportive of a low congruence model. The relationship between genetic and environmental influences on personality assessed by NPTs, APTs, and PDs is complex and does not fit easily into a low or high congruence model.

Copyright

Corresponding author

Author for correspondence: Kenneth S. Kendler, E-mail: kenneth.kendler@vcuhealth.org

References

Hide All
Akaike, H (1987) Factor analysis and AIC. Psychometrika 52, 317332.
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders, 3rd Edn. Washington, DC: American Psychiatric Association.
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, Revised 3rd Edn. Washington, DC: American Psychiatric Association.
American Psychiatric Association (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th Edn. Revised, Fourth-Revised ed. Washington, DC: American Psychiatric Association.
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th Edn. DSM-5. Washington, DC: American Psychiatric Association.
Austin, EJ and Deary, IJ (2000) The ‘four As’: a common framework for normal and abnormal personality? Personality and Individual Differences 28, 977995.
Boker, S, Neale, M, Maes, H, Wilde, M, Spiegel, M, Brick, T, Spies, J, Estabrook, R, Kenny, S, Bates, T, Mehta, P and Fox, J (2011) Openmx: an open source extended structural equation modeling framework. Psychometrika 76, 306317.
Clark, LA (1993) Schedule for Nonadaptive and Adaptive Personality (SNAP): Manual for Administration, Scoring, and Interpretation. Minneapolis: University of Minnesota Press.
Clark, LA, Vorhies, L and McEwen, JL (1994) Personality disorder symptomatology from the five-factor model perspective. In Costa, PT and Widiger, TA (eds), Personality Disorders and the Five-Factor Model of Personality. Washington, DC: American Psychological Association, 125147.
Costa, PT and Widiger, TA (2002) Personality Disorders and the Five-Factor Model of Personality, 2nd Edn. Washington, DC: American Psychological Association.
Czajkowski, N, Aggen, SH, Krueger, RF, Kendler, KS, Neale, MC, Knudsen, GP, Gillespie, N, Røysamb, E, Tambs, K and Reichborn-Kjennerud, T (2018) A twin study of normative personality and DSM-IV personality disorder criterion counts; evidence for separate genetic influences. American Journal of Psychiatry 175, 649656.
Dyce, JA and O'Connor, BP (1998) Personality disorders and the five-factor model: a test of facet-level predictions. Journal of Personality Disorders 12, 3145.
Eysenck, HJ and Eysenck, SBG (1975) Manual of the Eysenck Personality Questionnaire. London: Hodder and Stoughton.
Harris, JR, Magnus, P and Tambs, K (2006) The Norwegian Institute of Public Health twin program of research: an update. Twin Research and Human Genetics 9, 858864.
Horn, JL (1965) A rationale and test for the number of factors in factor analysis. Psychometrika 30, 179185.
Jang, KL and Livesley, WJ (1999) Why do measures of normal and disordered personality correlate? A study of genetic comorbidity. Journal of Personality Disorders 13, 1017.
Jang, K and Vernon, PA (2001) Genetics. In Livesley, WJ (ed.), Handbook of Personality Disorders: Theory, Research, and Treatment. New York: Guilford Press, pp. 177195.
Jang, KL, Livesley, WJ, Vernon, PA and Jackson, DN (1996) Heritability of personality disorder traits: a twin study. Acta Psychiatrica Scandinavica 94, 438444.
John, OP and Srivastava, S (1999) The big-five trait taxonomy: history, measurement, and theoretical perspectives. In Pervin, LA and John, OP (eds), Handbook of Personality: Theory and Research, 2nd Edn. New York: Guilford Press, pp. 102139.
John, OP, Donahue, EM and Kentle, RL (1991) The Big Five Inventory-Versions 4a and 54 Berkeley. CA: University of California Berkeley, Institute of Personality and Social Research.
Kendler, KS, Czajkowski, N, Tambs, K, Torgersen, S, Aggen, SH, Neale, C and Reichborn-Kjennerud, T (2006) Dimensional representations of DSM-IV Cluster A personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychological Medicine 36, 15831591.
Kendler, KS, Aggen, SH, Czajkowski, N, Roysamb, E, Tambs, K, Torgersen, S, Neale, MC and Reichborn-Kjennerud, T (2008) The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study. Archives of General Psychiatry 65, 14381446.
Kendler, KS, Aggen, SH, Neale, MC, Knudsen, GP, Krueger, RF, Tambs, K, Czajkowski, N, Ystrom, E, Orstavik, RE and Reichborn-Kjennerud, T (2015) A longitudinal twin study of cluster A personality disorders. Psychological Medicine 45, 15311538.
Kendler, KS, Aggen, SH, Gillespie, N, Neale, MC, Knudsen, GP, Krueger, RF, Czajkowski, N, Ystrom, E and Reichborn-Kjennerud, T (2017) The genetic and environmental sources of resemblance between normative personality and personality disorder traits. Journal of Personality Disorders 31, 193207.
Krueger, RF, Derringer, J, Markon, KE, Watson, D and Skodol, AE (2012) Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychological Medicine 42, 18791890.
Livesley, WJ (2007) A framework for integrating dimensional and categorical classifications of personality disorder. Journal of Personality Disorders 21, 199224.
Livesley, WJ and Jackson, DN (2009) Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ) Technical Manual. Port Huron, MI: Sigma Assessment Systems, Inc.
Livesley, WJ and Jang, KL (2008) The behavioral genetics of personality disorder. Annual Reviews of Clinical Psychology 4, 247274.
Livesley, WJ, Jang, KL, Jackson, DN and Vernon, PA (1993) Genetic and environmental contributions to dimensions of personality disorder. American Journal of Psychiatry 150, 18261831.
Livesley, WJ, Jang, KL and Vernon, PA (1998) Phenotypic and genetic structure of traits delineating personality disorder. Archives of General Psychiatry 55, 941948.
Lorenzo-Seva, U and ten Berge, JMF (2006) Tucker's congruence coefficient as a meaningful index of factor similarity. Methodology 2, 5764.
Markon, KE, Krueger, RF and Watson, D (2005) Delineating the structure of normal and abnormal personality: an integrative hierarchical approach. Journal of Personality and Social Psychology 88, 139157.
McGue, M (2002) Genetics of personality. In Rimoin, R, Pyeritz, R and Korf, B (eds.), Emery & Rimoin's Principles and Practice of Medical Genetics, 4th Edn. vol. 3. London: Churchill Livingstone, pp. 27912800.
Mehta, PD, Neale, MC and Flay, BR (2004) Squeezing interval change from ordinal panel data: latent growth curves with ordinal outcomes. Psychological Methods 9, 301333.
Neale, MC, Hunter, MD, Pritikin, JN, Zahery, M, Brick, TR, Kirkpatrick, RM, Estabrook, R, Bates, TC, Maes, HH and Boker, SM (2016) Openmx 2.0: extended structural equation and statistical modeling. Psychometrika 81, 535549.
Pfohl, B, Blum, N and Zimmerman, M (1995) Structured Interview for DSM-IV Personality (SIDP-IV). Iowa City: University of Iowa, Department of Psychiatry.
Raftery, AE (1993) Bayesian model selection in structural equation models. In Bollen, KA and Long, JS (eds), Testing Structural Equation Models, 1st Edn. Newbury Park, CA: Sage, pp. 163180.
R Development Core Team (2014) The R Project for Statistical Computing; R: A language and environment for statistical computing. [3.1.2]. Vienna, Austria, R Foundation for Statistical Computing. Computer Program.
Reichborn-Kjennerud, T (2008) Genetics of personality disorders. Psychiatric Clinics of North America 31, 421440.
Reichborn-Kjennerud, T, Czajkowski, N, Neale, MC, Orstavik, RE, Torgersen, S, Tambs, K, Roysamb, E, Harris, JR and Kendler, KS (2007) Genetic and environmental influences on dimensional representations of DSM-IV cluster C personality disorders: a population-based multivariate twin study. Psychological Medicine 37, 645653.
Reichborn-Kjennerud, T, Czajkowski, N, Ystrom, E, Orstavik, R, Aggen, SH, Tambs, K, Torgersen, S, Neale, MC, Roysamb, E, Krueger, RF, Knudsen, GP and Kendler, KS (2015) A longitudinal twin study of borderline and antisocial personality disorder traits in early to middle adulthood. Psychological Medicine 45, 31213131.
Reichborn-Kjennerud, T, Krueger, RF, Ystrom, E, Torvik, FA, Rosenstrom, TH, Aggen, SH, South, SC, Neale, MC, Knudsen, GP, Kendler, KS and Czajkowski, NO (2017) Do DSM-5 Section II personality disorders and Section III personality trait domains reflect the same genetic and environmental risk factors? Psychological Medicine 47, 22052215.
Revelle, W (2015) Psych: Procedures for Psychological, Psychometric, and Personality Research. [1.5.6]. Northwestern University. Computer Program.
Robins, E and Guze, SB (1970) Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. American Journal of Psychiatry 126, 983987.
Samuel, DB and Widiger, TA (2008) A meta-analytic review of the relationships between the five-factor model and DSM-IV-TR personality disorders: a facet level analysis. Clinical Psychology Review 28, 13261342.
Saulsman, LM and Page, AC (2004) The five-factor model and personality disorder empirical literature: a meta-analytic review. Clinical Psychology Review 23, 10551085.
South, SC, Reichborn-Kjennerud, T, Eaton, NR and Krueger, RF (2015) Genetics of personality. In Mikulincer, M, Shaver, PR, Cooper, ML and Larsen, RJ (eds.), APA handbooks in psychology. APA handbook of personality and social psychology, Vol. 4. Personality processes and individual differences. Washington, DC, US: American Psychological Association, pp. 31–60.
South, SC, Krueger, RF, Knudsen, GP, Ystrom, E, Czajkowski, N, Aggen, SH, Neale, MC, Gillespie, NA, Kendler, KS and Reichborn-Kjennerud, T (2016) A population based twin study of DSM-5 maladaptive personality domains. Personality Disorders 8, 366375.
Tambs, K, Ronning, T, Prescott, CA, Kendler, KS, Reichborn-Kjennerud, T, Torgersen, S and Harris, JR (2009) The Norwegian Institute of Public Health twin study of mental health: examining recruitment and attrition bias. Twin Research and Human Genetics 12, 158168.
Torgersen, S, Lygren, S, Oien, PA, Skre, I, Onstad, S, Edvardsen, J, Tambs, K and Kringlen, E (2000) A twin study of personality disorders. Comprehensive Psychiatry 41, 416425.
Torgersen, S, Czajkowski, N, Jacobson, K, Reichborn-Kjennerud, T, Roysamb, E, Neale, MC and Kendler, KS (2008) Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychological Medicine 38, 16171625.
Wright, ZE, Pahlen, S and Krueger, RF (2017) Genetic and environmental influences on Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) maladaptive personality traits and their connections with normative personality traits. Journal of Abnormal Psychology 126, 416428.
Zachar, P, Krueger, RF and Kendler, KS (2016) Personality disorder in DSM-5: an oral history. Psychological Medicine 46, 110.
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