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Some biochemical findings during pregnancy and after delivery in relation to mood change

Published online by Cambridge University Press:  09 July 2009

C. Barbara Ballinger ,
David S. G. Kay ,
Graham J. Naylor  and
Anne H. W. Smith
C. Barbara Ballinger*
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, and Dundee Psychiatric Services
David S. G. Kay
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, and Dundee Psychiatric Services
Graham J. Naylor
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, and Dundee Psychiatric Services
Anne H. W. Smith
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee, and Dundee Psychiatric Services
*
1Address for correspondence: Dr C. B. Ballinger, Department of Psychiatry, Ninewells Hospital and Medical School, Dundee.
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Synopsis

Thirty-four women who had vaginal deliveries of live infants completed behavioural ratings and supplied blood and 24-hour urine samples on three occasions during pregnancy and on three occasions after delivery. Approximately one third of the women indicated a distinct upswing in mood between Days 2 and 4 following delivery. These ‘positive mood change’ subjects showed changes in urinary cyclic AMP (adenosine 3′5′ cyclic monophosphate), plasma cyclic AMP, whole blood cell cyclic AMP, whole blood cell ATP (adenosine triphosphate), haematocrit and urinary 11 OHCS (11-hydroxycortisol steroids) following delivery which were different from those observed in the rest of the subjects and comparable with the biochemical changes described during upswings in mood in short-cycle manic-depressive subjects. There was also an indication that the women showing this upswing in mood following delivery were distinct in some respects on both behavioural ratings and biochemical findings during pregnancy.

Type
Research Article
Information
Psychological Medicine , Volume 12 , Issue 3 , August 1982 , pp. 549 - 556
Copyright
Copyright © Cambridge University Press 1982

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