Achur, RN, Freeman, WM and Vrana, KE (2010) Circulating cytokines as biomarkers of alcohol abuse and alcoholism. Journal of Neuroimmune Pharmacology 5, 83–91.
Aiello, AE, Dowd, JB, Jayabalasingham, B, Feinstein, L, Uddin, M, Simanek, AM, Cheng, CK, Galea, S, Wildman, DE and Koenen, K (2016) PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. Psychoneuroendocrinology 67, 133–141.
Antoni, FA, Hunter, EF, Lowry, PJ, Noble, JM and Seckl, JR (1992) Atriopeptin: an endogenous corticotropin-release inhibiting hormone. Endocrinology 130, 1753–1755.
Beech, RD, Qu, J, Leffert, JJ, Lin, A, Hong, KA, Hansen, J, Umlauf, S, Mane, S, Zhao, H and Sinha, R (2012) Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: preliminary findings. Alcoholism: Clinical and Experimental Research 36, 1487–1496.
Blake, DD, Weathers, FW, Nagy, LM, Kaloupek, DG, Gusman, FD, Charney, DS and Keane, TM (1995) The development of a clinician-administered PTSD scale. Journal of Traumatic Stress 8, 75–90.
Boks, MP, van Mierlo, HC, Rutten, BP, Radstake, TR, De Witte, L, Geuze, E, Horvath, S, Schalkwyk, LC, Vinkers, CH, Broen, JC and Vermetten, E (2015) Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology 51, 506–512.
Breen, MS, Maihofer, AX, Glatt, SJ, Tylee, DS, Chandler, SD, Tsuang, MT, Risbrough, VB, Baker, DG, O'Connor, DT, Nievergelt, CM and Woelk, CH (2015) Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 20, 1538–1545.
Breton, CV, Marsit, CJ, Faustman, E, Nadeau, K, Goodrich, JM, Dolinoy, DC, Herbstman, J, Holland, N, LaSalle, JM, Schmidt, R, Yousefi, P, Perera, F, Joubert, BR, Wiemels, J, Taylor, M, Yang, IV, Chen, R, Hew, KM, Freeland, DM, Miller, R and Murphy, SK (2017) Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 125, 511–526.
Carroll, JE, Irwin, MR, Levine, M, Seeman, TE, Absher, D, Assimes, T and Horvath, S (2017) Epigenetic aging and immune senescence in women with insomnia symptoms: findings from the women's health initiative study. Biological Psychiatry 81, 136–144.
Chen, BH, Marioni, RE, Colicino, E, Peters, MJ, Ward-Caviness, CK, Tsai, PC, Roetker, NS, Just, AC, Demerath, EW, Guan, W, Bressler, J, Fornage, M, Studenski, S, Vandiver, AR, Moore, AZ, Tanaka, T, Kiel, DP, Liang, L, Vokonas, P, Schwartz, J, Lunetta, KL, Murabito, JM, Bandinelli, S, Hernandez, DG, Melzer, D, Nalls, M, Pilling, LC, Price, TR, Singleton, AB, Gieger, C, Holle, R, Kretschmer, A, Kronenberg, F, Kunze, S, Linseisen, J, Meisinger, C, Rathmann, W, Waldenberger, M, Visscher, PM, Shah, S, Wray, NR, McRae, AF, Franco, OH, Hofman, A, Uitterlinden, AG, Absher, D, Assimes, T, Levine, ME, Lu, AT, Tsao, PS, Hou, L, Manson, JE, Carty, CL, LaCroix, AZ, Reiner, AP, Spector, TD, Feinberg, AP, Levy, D, Baccarelli, A, van Meurs, J, Bell, JT, Peters, A, Deary, IJ, Pankow, JS, Ferrucci, L and Horvath, S (2016) DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY) 8, 1844–1865.
Cook, RT, Ballas, ZK, Waldschmidt, TJ, Vandersteen, D, LaBrecque, DR and Cook, BL (1995) Modulation of T-cell adhesion markers, and the CD45R and CD57 antigens in human alcoholics. Alcoholism: Clinical and Experimental Research 19, 555–563.
Cook, RT, Waldschmidt, TJ, Ballas, ZK, Cook, BL, Booth, BM, Stewart, BC and Garvey, MJ (1994) Fine T-cell subsets in alcoholics as determined by the expression of l-selectin, leukocyte common antigen, and β-integrin. Alcoholism: Clinical and Experimental Research 18, 71–80.
Darrow, SM, Verhoeven, JE, Revesz, D, Lindqvist, D, Penninx, BW, Delucchi, KL, Wolkowitz, OM and Mathews, CA (2016) The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons. Psychosomatic Medicine 78, 776–787.
Davis, EG, Humphreys, KL, McEwen, LM, Sacchet, MD, Camacho, MC, MacIsaac, JL, Lin, DTS, Kobor, MS and Gotlib, IH (2017) Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume. Translational Psychiatry 7, e1223.
Durso, DF, Bacalini, MG, Sala, C, Pirazzini, C, Marasco, E, Bonafé, M, do Valle, ÍF, Gentilini, D, Castellani, G and Faria, AMC (2017) Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer. Oncotarget 8, 23237.
First, MB, Gibbon, M, Spitzer, RL and Benjamin, LS (1997). User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders: SCID-II. Washington, DC: American Psychiatric Association Publishing.
Fülöp, T, Dupuis, G, Witkowski, JM and Larbi, A (2016) The role of immunosenescence in the development of age-related diseases. Revista de Investigación Clínica 68, 84–91.
Glahn, A, Riera Knorrenschild, R, Rhein, M, Haschemi Nassab, M, Groschl, M, Heberlein, A, Muschler, M, Frieling, H, Bleich, S and Hillemacher, T (2014) Alcohol-induced changes in methylation status of individual CpG sites, and serum levels of vasopressin and atrial natriuretic peptide in alcohol-dependent patients during detoxification treatment. European Addiction Research 20, 143–150.
Hannum, G, Guinney, J, Zhao, L, Zhang, L, Hughes, G, Sadda, S, Klotzle, B, Bibikova, M, Fan, JB, Gao, Y, Deconde, R, Chen, M, Rajapakse, I, Friend, S, Ideker, T and Zhang, K (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell 49, 359–367.
Harlaar, N, Bryan, AD, Thayer, RE, Karoly, HC, Oien, N and Hutchison, KE (2014) Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. Alcoholism: Clinical and Experimental Research 38, 713–721.
Horvath, S (2013) DNA methylation age of human tissues and cell types. Genome Biology 14, R115.
Horvath, S, Gurven, M, Levine, ME, Trumble, BC, Kaplan, H, Allayee, H, Ritz, BR, Chen, B, Lu, AT, Rickabaugh, TM, Jamieson, BD, Sun, D, Li, S, Chen, W, Quintana-Murci, L, Fagny, M, Kobor, MS, Tsao, PS, Reiner, AP, Edlefsen, KL, Absher, D and Assimes, TL (2016) An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biology 17, 171.
Jovanovic, T, Vance, LA, Cross, D, Knight, AK, Kilaru, V, Michopoulos, V, Klengel, T and Smith, AK (2017) Exposure to violence accelerates epigenetic aging in children. Scientific Reports 7, 8962.
Kananen, L, Marttila, S, Nevalainen, T, Kummola, L, Junttila, I, Mononen, N, Kähönen, M, Raitakari, O, Hervonen, A and Jylhä, M (2016) The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies. Age 38, 65.
Kessler, RC, Sonnega, A, Bromet, E, Hughes, M and Nelson, CB (1995) Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry 52, 1048–1060.
Kozlenkov, A, Jaffe, AE, Timashpolsky, A, Apontes, P, Rudchenko, S, Barbu, M, Byne, W, Hurd, YL, Horvath, S and Dracheva, S (2017) DNA methylation profiling of human prefrontal cortex neurons in heroin users shows significant difference between genomic contexts of hyper-and hypomethylation and a younger epigenetic age. Genes 8, 152.
Kubany, ES, Haynes, SN, Leisen, MB, Owens, JA, Kaplan, AS, Watson, SB and Burns, K (2000) Development and preliminary validation of a brief broad-spectrum measure of trauma exposure: the Traumatic Life Events Questionnaire. Psychological Assessment 12, 210–224.
Leclercq, S, Cani, PD, Neyrinck, AM, Starkel, P, Jamar, F, Mikolajczak, M, Delzenne, NM and de Timary, P (2012) Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects. Brain, Behavior, and Immunity 26, 911–918.
Levine, ME, Lu, AT, Bennett, DA and Horvath, S (2015) Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning. Aging (Albany NY) 7, 1198–1211.
Liu, C, Marioni, RE, Hedman, AK, Pfeiffer, L, Tsai, PC, Reynolds, LM, Just, AC, Duan, Q, Boer, CG, Tanaka, T, Elks, CE, Aslibekyan, S, Brody, JA, Kuhnel, B, Herder, C, Almli, LM, Zhi, D, Wang, Y, Huan, T, Yao, C, Mendelson, MM, Joehanes, R, Liang, L, Love, SA, Guan, W, Shah, S, McRae, AF, Kretschmer, A, Prokisch, H, Strauch, K, Peters, A, Visscher, PM, Wray, NR, Guo, X, Wiggins, KL, Smith, AK, Binder, EB, Ressler, KJ, Irvin, MR, Absher, DM, Hernandez, D, Ferrucci, L, Bandinelli, S, Lohman, K, Ding, J, Trevisi, L, Gustafsson, S, Sandling, JH, Stolk, L, Uitterlinden, AG, Yet, I, Castillo-Fernandez, JE, Spector, TD, Schwartz, JD, Vokonas, P, Lind, L, Li, Y, Fornage, M, Arnett, DK, Wareham, NJ, Sotoodehnia, N, Ong, KK, van Meurs, JB, Conneely, KN, Baccarelli, AA, Deary, IJ, Bell, JT, North, KE, Liu, Y, Waldenberger, M, London, SJ, Ingelsson, E and Levy, D (2016) A DNA methylation biomarker of alcohol consumption. Molecular Psychiatry 23, 422–433.
Logue, MW, Smith, AK, Wolf, EJ, Maniates, H, Stone, A, Schichman, SA, McGlinchey, RE, Milberg, W and Miller, MW (2017) The correlation of methylation levels measured using Illumina 450 K and EPIC BeadChips in blood samples. Epigenomics 9, 1363–1371.
Macaulay, R, Akbar, AN and Henson, SM (2013) The role of the T cell in age-related inflammation. Age 35, 563–572.
Marioni, RE, Shah, S, McRae, AF, Chen, BH, Colicino, E, Harris, SE, Gibson, J, Henders, AK, Redmond, P, Cox, SR, Pattie, A, Corley, J, Murphy, L, Martin, NG, Montgomery, GW, Feinberg, AP, Fallin, MD, Multhaup, ML, Jaffe, AE, Joehanes, R, Schwartz, J, Just, AC, Lunetta, KL, Murabito, JM, Starr, JM, Horvath, S, Baccarelli, AA, Levy, D, Visscher, PM, Wray, NR and Deary, IJ (2015) DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology 16, 25.
McGlinchey, RE, Milberg, WP, Fonda, JR and Fortier, CB (2017). A methodology for assessing deployment trauma and its consequences in OEF/OIF/OND veterans: the TRACTS longitudinal prospective cohort study. International Journal of Methods in Psychiatric Research 26, e1556.
McKinney, BC, Lin, H, Ding, Y, Lewis, DA and Sweet, RA (2017) DNA methylation evidence against the accelerated aging hypothesis of schizophrenia. NPJ Schizophrenia 3, 13.
Miller, MW, Lin, AP, Wolf, EJ and Miller, DR (2017) Oxidative stress, inflammation, and neuroprogression in chronic PTSD. Harvard Review of Psychiatry 26, 57–69.
Miller, MW, Wolf, EJ, Reardon, A, Greene, A, Ofrat, S and McInerney, S (2012) Personality and the latent structure of PTSD comorbidity. Journal of Anxiety Disorders 26, 599–607.
Muschler, MA, Hillemacher, T, Kraus, C, Kornhuber, J, Bleich, S and Frieling, H (2010) DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence. Journal of Neural Transmission (Vienna) 117, 513–519.
Passos, IC, Vasconcelos-Moreno, MP, Costa, LG, Kunz, M, Brietzke, E, Quevedo, J, Salum, G, Magalhães, PV, Kapczinski, F and Kauer-Sant'Anna, M (2015) Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. The Lancet Psychiatry 2, 1002–1012.
Perna, L, Zhang, Y, Mons, U, Holleczek, B, Saum, KU and Brenner, H (2016) Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clinical Epigenetics 8, 64.
Philibert, RA, Penaluna, B, White, T, Shires, S, Gunter, T, Liesveld, J, Erwin, C, Hollenbeck, N and Osborn, T (2014) A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. Epigenetics 9, 1212–1219.
Quach, A, Levine, ME, Tanaka, T, Lu, AT, Chen, BH, Ferrucci, L, Ritz, B, Bandinelli, S, Neuhouser, ML and Beasley, JM (2017) Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging (Albany NY) 9, 419.
Ratanatharathorn, A, Boks, MP, Maihofer, AX, Aiello, AE, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bromet, E, Dennis, M, Garrett, ME, Geuze, E, Guffanti, G, Hauser, MA, Kilaru, V, Kimbrel, NA, Koenen, KC, Kuan, PF, Logue, MW, Luft, BJ, Miller, MW, Mitchell, C, Nugent, NR, Ressler, KJ, Rutten, BPF, Stein, MB, Vermetten, E, Vinkers, CH, Youssef, NA, Workgroup, VAM-AM, Workgroup, PPE, Uddin, M, Nievergelt, CM and Smith, AK (2017) Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174, 619–630.
Sommershof, A, Aichinger, H, Engler, H, Adenauer, H, Catani, C, Boneberg, E-M, Elbert, T, Groettrup, M and Kolassa, I-T (2009) Substantial reduction of naive and regulatory T cells following traumatic stress. Brain, Behavior, and Immunity 23, 1117–1124.
Spitzer, R, Gibbon, M and Williams, J (1998) Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition (February 1996 Final). New York, NY: Biometrics Research Department, New York State Psychiatric Institute.
Strohle, A, Feller, C, Strasburger, CJ, Heinz, A and Dimeo, F (2006) Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide. Psychoneuroendocrinology 31, 1127–1130.
Szabo, G and Mandrekar, P (2009) A recent perspective on alcohol, immunity, and host defense. Alcoholism: Clinical and Experimental Research 33, 220–232.
Voisey, J, Lawford, BR, Morris, CP, Wockner, LF, Noble, EP, Young, RM and Mehta, D (2017) Epigenetic analysis confirms no accelerated brain aging in schizophrenia. NPJ Schizophrenia 3, 26.
Weidner, CI and Wagner, W (2014) The epigenetic tracks of aging. Biological Chemistry 395, 1307–1314.
Wiedemann, K, Jahn, H, Yassouridis, A and Kellner, M (2001) Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings. Archives of General Psychiatry 58, 371–377.
Wolf, EJ and Morrison, FM (2017) Traumatic stress and accelerated cellular aging: from epigenetics to cardiometabolic disease. Current Psychiatry Reports 19, 75.
Wolf, EJ, Logue, MW, Hayes, JP, Sadeh, N, Schichman, SA, Stone, A, Salat, DH, Milberg, W, McGlinchey, R and Miller, MW (2016) Accelerated DNA methylation age: associations with PTSD and neural integrity. Psychoneuroendocrinology 63, 155–162.
Wolf, EJ, Logue, MW, Stoop, TB, Schichman, SA, Stone, A, Sadeh, N, Hayes, JP and Miller, MW (2017). Accelerated DNA methylation age: associations with PTSD and mortality. Psychosomatic Medicine 80, 42–48.
Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Va Mid-Atlantic Mirecc, Workgroup, Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPF, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM and Logue, MW (2018) Traumatic stress and accelerated DNA methylation age: a meta-analysis. Psychoneuroendocrinology 92, 123–134.
Zannas, AS, Arloth, J, Carrillo-Roa, T, Iurato, S, Roh, S, Ressler, KJ, Nemeroff, CB, Smith, AK, Bradley, B, Heim, C, Menke, A, Lange, JF, Bruckl, T, Ising, M, Wray, NR, Erhardt, A, Binder, EB and Mehta, D (2015) Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biology 16, 266.
Zhang, H and Gelernter, J (2017) DNA methylation and alcohol use disorders: progress and challenges. The American Journal on Addictions 26, 502–515.
Zhang, R, Miao, Q, Wang, C, Zhao, R, Li, W, Haile, CN, Hao, W and Zhang, XY (2013) Genome-wide DNA methylation analysis in alcohol dependence. Addiction Biology 18, 392–403.
Zhao, R, Zhang, R, Li, W, Liao, Y, Tang, J, Miao, Q and Hao, W (2013) Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. Asia-Pacific Psychiatry 5, 39–50.
Zheng, Y, Joyce, BT, Colicino, E, Liu, L, Zhang, W, Dai, Q, Shrubsole, MJ, Kibbe, WA, Gao, T, Zhang, Z, Jafari, N, Vokonas, P, Schwartz, J, Baccarelli, AA and Hou, L (2016) Blood epigenetic age may predict cancer incidence and mortality. EBioMedicine 5, 68–73.