Skip to main content Accessibility help
×
Home

Plaques, tangles and Alzheimer's disease1

  • B. E. Tomlinson
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Plaques, tangles and Alzheimer's disease1
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Plaques, tangles and Alzheimer's disease1
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Plaques, tangles and Alzheimer's disease1
      Available formats
      ×

Abstract

  • An abstract is not available for this content so a preview has been provided below. To view the full text please use the links above to select your preferred format.

Copyright

References

Hide All
Ball, M. J. (1976). Neurofibrillary tangles and the pathogenesis of dementia; a quantitative study. Neuropathology and Applied Neurobiology 2, 395410.
Blessed, G., Tomlinson, B. E. & Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry 114, 797811.
Brody, H. (1955). Organisation of the cerebral cortex. III: A study of ageing in the human cerebral cortex. Journal of Comparative Neurology 102, 511556.
Brody, H. (1970). Structural changes in ageing nervous system. Interdisciplinary Topics in Gerontology 7, 921.
Brody, H. (1976). An examination of cerebral cortex and brain stem ageing. In Neurobiology of Ageing, vol. 3. (ed. Terry, R. D. and Gershon, S.), pp. 177181. Raven Press: New York.
Bruce, M. E. & Fraser, A. H. (1975). Amyloid plaques in the brains of mice infected with scrapie: morphological variations and staining properties. Neuropathology and Applied Neurobiology 1, 189202.
Bruce, M. E., Dickinson, A. G. & Fraser, H. (1976). Cerebral amyloidosis in scrapie in the mouse: effect of agent strain and mouse genotype. Neuropathology and Applied Neurobiology 2, 471478.
Brun, A. & Gustafson, L. (1976). Distribution of cerebral degeneration in Alzheimer's disease. A clinico-pathological study. Archiv für Psyhiatrie und Nervenkrankheiten 223, 15133.
Brunmuhl, A. (1956). Kongophile Angiopathie und senile Plaques bei greisen Hunden. Archiv für Psychiatrie und Nervenkrankhieten 194, 396414.
Burger, P. C. & Vogel, F. S. (1973). The development of the pathological changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. American Journal of Pathology 73, 457476.
Burkes, J. S., Huddlestone, J., Alfrey, A. C., Norenberg, M. D. S. & Lewin, E. (1976). A fatal encephalopathy in chronic haemodialysis patients. Lancet i, 764768.
Christie, J. E., Glen, A. I. M., Yates, C. M., Blackburn, I. M., Shering, A., JeHinek, E. H. & Zeisel, S. (1969). Choline and lecithin effects on CSF choline levels and on cognitive function in Alzheimer pre-senile dementia. In Alzheimer's Disease. Early Recognition of Potentially Reversible Deficits (ed. Glen, A. I. M. and Whalley, L. J.), pp. 163168. Churchill Livingstone: Edinburgh.
Colon, E. J. (1972). The elderly brain. A quantitative analysis of the cerebral cortex in two cases. Psychiatrie, Neurologie Neurochirurgie (Amsterdam) 75, 261270.
Constantinidis, J. (1978). Is Alzheimer's disease a major form of senile dementia? Clinical, anatomical and genetic data. In Alzheimer's Disease, Senile Dementia and Related Disorder (Ageing, vol. 7) (ed. Katzman, R.Terry, R. D. and Bick, K. L.), pp. 1525. Raven Press: New York.
Constatinidis, J., Richard, J. & de Ajuriaguerra, J. (1978) Dementia with senile plaques and neurofibrillary tangles. In Studies in Geriatric Psychiatry (ed. lsaacs, A. D. and Post, F.), pp. 119152. Wiley: New York.
Cornwell, G. G. & Westermark, P. (1980). Senile amyloidosis: a protean manifestation of the ageing process. Journal of Clinical Pathology 33, 11461152.
Corsellis, J. A. N. (1962). Mental Illness and the Ageing Brain. Oxford University Press: London.
Corsellis, J. A. N. (1976 a) Ageing and the dementias. In Greenfield's Neuropathology (3rd edn) (ed. Blackwood, W. and Corsellis, J. A. N.), pp. 796848. Edward Arnold: London.
Corsellis, J. A. N. (1976 b). Some observations on the Purkinje cell population and on brain volume in human ageing. In Neurobiology of Ageing, vol. 3. (ed. Terry, R. D. and Gershon, S.), pp. 205209. Raven Press: New York.
Corsellis, J. A. N., Bruton, C. J. & Freeman-Browne, D. (1973). The aftermath of boxing. Psychological Medicine 3, 270303.
Crapper, D. R. (1973). Experimental neurofibrillary degeneration and altered electrical activity. Electroencephalography and Clinical Neurophysiology 35, 575588.
Crapper, D. R. (1976). Functional consequences of neurofibrillary degeneration. In Neurobiology of Ageing, vol. 3. (ed. Terry, R. D. and Gershon, S.), pp. 405432. Raven Press: New York.
Crapper, D. R. & Dalton, A. J. (1973 a). Aluminium induced neurofibrillary degeneration, brain electrical activity and alterations in acquisition and retention. Physiology and Behaviour 10, 935945.
Crapper, D. R. & Dalton, A. J. (1973 b). Alterations in short term retention, conditioned avoidance response acquisition and motivation following aluminium induced neurofibrillary degeneration. Physiology and Behaviour 10, 925933.
Crapper, D. R. & Tomko, G. J. (1975). Neuronal correlates of an encephalopathy induced by aluminium neurofibrillary degeneration.Brain Research 97, 253264.
Crapper, D. R., Krishnan, S. S. & Quittkat, S. (1976). Aluminium, neurofibrillary degeneration and Alzheimer's disease. Brain 99 6780.
Crapper-McLachlan, D. R. & De Boni, U. (1980). Aetiologic factors in senile dementia of Alzheimer type. In Ageing of the Brain and Dementia (Aging, vol. 13) (ed. Amaducci, L., Davison, A. N. and Antuono, P.), pp. 173181. Raven Press: New York.
Davies, P. & Maloney, A. F. (1976). Selective loss of cholinergic neurons in Alzheimer's disease. Lancet ii, 1403.
Davies, P. & Verth, A. H. (1978). Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer-type dementia brains. Brain Research 138, 385392.
Dayan, A. D. & Ball, M. J. (1973). Histometric observations on the metabolism of tangle-bearing neurons. Journal of Neurological Science 19, 422426.
De Boni, U. & Crapper, R. D. (1978). Paired helical filaments of the Alzheimer type in cultured neurons. Nature 271, 566568.
De Boni, U., Otoos, S., Scott, J. W. & Crapper, D. R. (1976). Neurofibrillary degeneration induced by systemic aluminium. Acta Neuropathologica (Berlin) 35, 285294.
De Fendis, F. V. (1974). Central Cholinergic Systems and Behaviour. Academic Press: New York.
Dickinson, A. G., Meikel, V. M. & Fraser, H. (1968). Identification of a gene which controls the incubation period of some strains of scrapie in mice. Journal of Comparative Pathology 78, 293299.
Dickinson, A. G., Meikel, V. M. & Fraser, H. (1969). Genetic control of the concentration of ME7 scrapie agent in the brain of mice. Journal of Comparative Pathology 79, 1522.
Duckett, S. & Galle, p. (1980). Electron–microprobe studies of aluminium in the brains of cases of Alzheinier's disease and ageing patients. Journal of Neuropathology and Experimental Neurology 39, 350.
Erlich, S. S. & Davis, R. L. (1980). Alzheimer's disease in the very aged. Journal of Neuropathology and Experimental Neurology 39,352.
Etienne, P., Gauthier, S., Dastoor, D., Collier, B. & Ratner, J. (1979). Alzheimer's disease: clinical effect of lecithin treatment. In Alzheimer's Disease. Early Recognition of Potentially Reversible Deficits (ed. Glen, A. I. M. and Whalley, L. J.), pp. 173178. Churchill Livingstone: Edinburgh.
Gambetti, P., Velasco, M. E., Dahi, D., Bignami, A., Roessmann, U. & Sindely, S. D. (1980). Alzheimer's neurofibrillary tangles: an immunohistochemical study. In Aging of the Brain and Dementia (Aging, vol. 13) (ed. Amaducci, L., Davison, A. N. and Antuono, P.), pp. 5563. Raven Press: New York.
Gambetti, P., Autilio-Gambetti, L. & Shecket, G. (1981). Immunological and silver staining characteristics of neurofibrillary tangles of Alzheimer type (NFT-AT). Journal of Neuropathology and Experimental Neurology 30, 317.
Ghetti, B. (1980). Experimental studies on neurofibrillary degeneration. In Ageing of the Brain and Dementia (Aging, vol. 13) (ed. Amaducci, L., Davison, A. N. and Antuono, P.), pp. 183198. Raven Press: New York.
Gibbs, C. J., Gadjusek, D. C. & Amyer, H. (1979). Strain variations in the viruses of Creutzfeldt–Jakob disease and Kuru. In Slow Transmissible Diseases of the Nervous System, vol. 2. (ed. Prusiner, S. B. and Hadlow, W. J.), pp. 87110. Academic Press: New York.
Gibson, P. H., Stones, M. & Tomlinson, B. E. (1976). Senile changes in the human neocortex and hippocampus compared by the use of the electron and light microscopes. Journal of Neurological Science 27, 389405.
Glenner, G. G., Terry, W. & Isersky, C. (1973). Amyloidosis: its nature and pathogenesis. Seminal Haematology 10, 6586.
Gonatas, N. K. & Gambetti, P. (1970). The pathology of the synapse in Alzheimer's disease. In Ciba Foundation Synposium on Alzheimer's Disease and Related Conditions (ed. Wolstenholme, G. E. W. and O'Connor, M.), pp. 169183. Churchill Living-Stone: London.
Gonatas, N. K., Anderson, W. & Evangelista, I. (1967). The contribution of altered synapses in the senile plaque: an electronmicroseopic study in Alzheimer's dementia. Journal of Neuropathology and Experimental Neurology 26, 2539.
Grundke-Iqbal, I., Johnson, A. B., Terry, R. D., Wisniewski, H. M. & lqbal, K. (1979). Alzheimer neurofibrillary tangles: antiserum and immunohistological staining. Annals of Neurology 6, 532539.
Henderson, G., Tomlinson, B. E. & Gibson, P. H. (1980). Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer. Journal of Neurological Science 46, 113136.
Hirano, A. (1974). Parkinsonism-dementia complex on Guam: current status of the problem.In Proceedings of the 10th International Congress of Neurology,Barcelona1973 (ed. Subirana, A. and Espadaler, J. M.), p. 348. Excerpta Medics: Amsterdam.
Hirano, A., Malamud, N. & Kurland, L. T. (1961). Parkinsonism-dementia complex, an endemic disease on the Island of Guam. II: Pathological features. Brain 84, 662679.
Hubbard, B. M. & Anderson, J. M. (1981). A quantitative study of cerebral atrophy in old age and senile dementia. Journal of Neurological Science 50, 135145.
Iqbal, K., Wisniewski, H. M., Shelanski, M. L., Brostoff, S., Liwnicz, B. H. & Terry, R. D. (1974). Protein changes in senile dementia. Brain Research 77, 337343.
Iqbal, K., Wisniewski, H. M., Grundke-Iqbal, I., Koothals, J. K. & Terry, R. D. (1975). Chemical pathology of neurofibrils: neurofibrillary tangles of Alzheimer's pre-senile dementia. Journal of Histochemistry and Cytochemistry 23, 563569.
Iqbal, K., Grundke-Iqbal, I., Wisniewski, H. M. & Terry, R. D. (1978). Chemical relationship of the paired helical filaments of Alzheimer's dementia to human normal neurofilaments and neurotubules. Brain Research 142, 321332.
Ishii, T. (1976). On various ultrastructural types of distended processes and degenerated synapses in senile brain, particularly those in senile plaques. Advances in Neurological Science 20, 373384.
Ishii, T. & Haga, S. (1976). Immunoelectronmicroscopic localisation of immunoglobulins in amyloid fibrils of senile plaques. Acta Neuropathologica (Berlin) 36, 243249.
Jervis, G. A. (1948). Early senile dementia in mongoloid idiocy. American Journal of Psychiatry 105, 102106.
Johnson, A. B., Cohen, S. A., Said, S. I. & Terry, R. D. (1981). Neuritic plaque amyloid, microangiopathy and Alzheimer neurofibrillary tangles: do they share a common antigen? Journal of Neuropathology and Experimental Neurology 40, 310.
Karczmar, A. G. (1975). Cholinergic influences on behaviour. In Cholinergic Mechanisms (ed. Waser, P. G.), pp. 501529. Raven Press: New York.
Kidd, M. (1963). Paired helical filaments in electron microscopy in Alzheimer's disease. Nature (London) 197, 192193.
Kidd, M. (1964). Alzheimer's disease – an electron microscopic study. Brain 87, 307321.
Klatzo, I., Wisniewski, H. & Streicher, E. (1965). Experimental production of neurofibrillary degeneration. I. Light microscopic observations. Journal of Neuropathology and Experimental Neurology 24, 187199.
Krigman, M. R., Feldman, R. G. & Bensch, K. (1965). Alzheimer's presenile dementia. A histochemical and electronmicroscopic study. Laboratory Investigation 14, 381396.
Liwnicz, B. H., Kristensson, K., Wisniewski, H. M., Shelanski, M. L. & Terry, R. D. (1974). Observations on axoplasmic transport in rabbits with aluminium induced neurofibrillary tangles. Brain Research 80, 413420.
Loew, D. M. (1980). Pharmacological approaches to the treatment of senile dementia. In Aging of the Brain and Dementia (Aging, vol. 13) (ed. Amaducci, L., Davison, A. N. and Antuono, P.), pp. 287304. Raven Press: New York.
Malamud, N., Hirano, A. & Kurland, L. T. (1961). Pathoanatomic changes in amyotrophic lateral sclerosis on Guam. Archives of Neurology (Chicago) 5, 401415.
Mandybur, T. I. (1975). The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology (Minneapolis) 25, 120126.
Mandybur, T. I., Nagpaul, A. S., Pappas, Z. & Niklowitz, W. J. (1977). Alzheimer's neurofibrillary change in Subacute sclerosing panencephalitis. Annals of Neurology 1, 103107.
Matsuyama, H. & Nakamura, S. (1978). Senile changes in the brain in the Japanese: incidence of Alzheimer's neurofibrillary change and senile plaques. In Alzheimer's Disease, Senile Dementia and Related Diseases (Aging, vol. 7) (ed. Katzman, R., Terry, R. D. and Bick, K. L.), pp. 287297. Raven Press: New York.
McDermott, J. R., Smith, A. I., Iqbal, K. & Wisniewski, H. M. (1977). Aluminium and Alzheimer's disease. Lancet ii, 710711.
McDermott, J. R., Ward, M. K., Smith, A. I., Parkinson, I. S. & Kerr, D. N. S. (1978). Brain aluminium concentrations in dialysis encephalopathy. Lancet i, 901903.
Mehraein, P., Yamada, M. & Tarnowska-Dzidusko, E. (1975). Quantitation studies on dendrites in Alzheimer's disease and senile dementia. In Physiology and Pathology of Dendrites (ed. Kreutzberg, G. W.), pp. 453458. Raven Press: New York.
Morimatsu, M., Hirai, S., Murimatsu, A. & Yoshikawa, M. (1975). Senile degenerative brain lesions and dementia. Journal of the American Geriatric Society 23, 390406.
Mountjoy, C. Q., Tomlinson, B. E. & Gibson, P. H. (1982). Amyloid and senile plaques and cerebral blood vessels. A semi-qualitative investigation of a possible relationship. (To be published).
Olson, M. I. & Shaw, C. (1969). Pre-senile dementia and Alzheimer's disease in mongolism. Brain 92, 147.
Oyanagi, S. (1979). Aging of the central nervous system and its fine structure. Neurofibrillary change and senile plaques. Seishin Iqatu 21, 834846. (In Japanese – quoted by Yagashita et al. 1981.)
Paula-Barbosa, M. N., Brito, R., Silva, C. A., Farin, R. & Cruz, C. (1979). Neurofibrillary changes in the cerebral cortex of a patient with S.S.P.E. Acta Neuropathologica 48, 157160.
Pauli, B. & Luginbühl, G. (1971). Fluorescenzmikrokopische Untersuchungen der cerebralen Amyloidose bei alten Hunden und senilen Menschen. Acta neuropathologica (Berlin) 19, 121128.
Peri, D. P. & Brody, A. R. (1980). Alzheimer's disease: X-ray spectrometric evidence of aluminium accumulation in neurofibrillary tangle-bearing neurons. Science 208, 297298.
Perry, E. K. & Perry, R. H. (1980). The cholinergic system in Alzheimer's disease. In Biochemistry of Dementia (ed. Roberts, P. J.), pp. 135183. John Wiley & Sons: Chichester.
Perry, E. K., Perry, R. H., Blessed, G. & Tomlinson, B. E. (1977). Necropsy evidence of central cholinergic deficits in senile dementia. Lancet i, 189.
Perry, E. K., Tomlinson, B. E., Blessed, G., Bergmann, K. & Perry, R. H. (1978). Correlation of cholinergic abnormalities with senile plaques and ventral test scores in senile dementia. British Medical Journal ii, 14571459.
Perry, E. K., Oakley, A. E., Candy, J. M. & Perry, R. H. (1981). Properties and possible significance of substance P and insulin fibrils. Neuroscience Letters 25, 321325.
Powers, J. M. & Spicer, S. S. (1977). Histochemical similarity of senile plaque amyloid to apudamyloid. Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin 376, 107115.
Powers, J. M. & Skeen, J. T. (1980). An immunoperoxidase study of senile plaques. Journal of Neuropathology and Experimental Neurology 39, 385.
Roth, M., Tomlinson, B. E. & Blessed, G. (1966). Correlation between scores for dementia and counts of ‘senile plaques’ in cerebral grey matter of elderly subjects. Nature (London) 209, 109.
Scheibel, A. B. (1978). Structural aspects of the ageing brain: spine systems and the dendritic arbor. In Alzheimer's Disease, Senile Dementia and Related Disorders (Aging, vol. 7) (ed. Katzman, R., Terry, R. D. and Bick, K. L.), pp. 353373. Raven Press: New York.
Scheibel, M. E., Lindsay, R. D., Tomiyasu, U. & Scheibel, A. B. (1975). Progessive dendritic changes in the ageing human cortex. Journal of Neuropathology and Experimental Neurology 47, 392403.
Schlaepfer, W. W. (1978). Deformation of isolated neurofilaments and the pathogenesis of neurofibrillary pathology. Journal of Neuropathology and Experimental Neurology 37, 244254.
Schochet, S. S. Jr, Lampert, P. W. & Earle, K. M. (1968). Neuronal changes induced by intrathecal vincristine sulfate. Journal of Neuropathology and Experimental Neurology 27, 645658.
Schwartz, P. (1970). Amyloidosis: Cause and Manifeslations of Senile Deterioration. C. C. Thomas: Springfield, III.
Shefer, V. G. (1973). Absolute number of neurons and thickness of the cerebral cortex during aging, senile vascular dementia and Pick's and Alzheimer's disease. Neuroscience and Behavioural Physiology 6, 319324.
Shibayama, H. & Kitoh, J. (1978). Electronmicroscopic structure of the Alzheimer's neruofibrillary changes in a case of atypical senile dementia. Acta Neuropathologica (Berlin) 41, 229234.
Solitare, G. B. & Lamarche, J. B. (1966). Alzheimer's disease and senile dementia as seen in mongoloids. American Journal of Mental Deficiency 70, 840848.
Spillane, J. A., White, P., Goodhardt, M. J., Flack, R. H. A., Bowen, D. M. & Davison, A. N. (1977). Selective vulnerability of neurons in organic dementia. Nature (London) 266, 558559.
Terry, R. D. (1963). The fine structure of neurofibrillary tangles in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 22, 269292.
Terry, R. D. & Pena, C. (1965). Experimental production of neurofibrillary degeneration. 2. Electronmicroscopy, phosphatase histochemistry and electron probe analysis. Journal of Neuropathology and Experimental Neurology 24, 200210.
Terry, R. D. & Wisniewski, H. (1970). The ultrastructure of the neurofibrillary tangle and the senile plaque. In Ciba Foundation Symposium on Alzheimer's Disease and Related Conditions (ed. Wolstenholme, G. E. and O'Connor, M.), pp. 145168. Churchill Livingstone: London.
Terry, R. D., Gonatas, N. K. & Weiss, M. (1964). Ultrastructural studies in Alzheimer's presenile dementia. American Journal of Pathology 44, 269297.
Terry, R. D., Peck, A., Deteresa, R., Schechter, R. & Horoupian, D. S. (1980). Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Journal of Neuropathology and Experimental Neurology 39, 314.
Tomko, G. J. & Crapper, D. R. (1974). Neuronal variability: non-stationary responses to identical visual stimuli. Brain Research 79, 405418.
Tomlinson, B. E. (1972). Morphological brain changes in non- demented old people. In Aging of the Central Nervous System (ed. Van Praag, H. M. and Kalverboer, A. F.), pp. 3857. Bohn: Haarlem.
Tomlison, B. E. (1977). The pathology of dementia. In Dementia (2nd edn) (ed. Wells, C. E.), pp. 113180. F. A. Davis: Philadelphia.
Tomlinson, B. E. (1979). The ageing brain. In Recent Advances in Neuropathology (ed. Smith, W. T. and Cavanagh, J. B.), pp. 129159. Churchill Livingstone: Edinburgh.
Tomlinson, B. E. & Henderson, G. (1976). Some quantitative cerebral findings in normal and demented old people. In Neurobiology of Aging, vol. 3 (ed. Terry, R. D. and Gershon, S.), pp. 183204. Raven Press: New York.
Tomlinson, B. E. & Irving, D. (1977). The numbers of limb motor neurons in the human lumbosacral cord throughout life. Journal of Neurological Science 34, 213219.
Tomlinson, B. E. & Kitchener, D. (1972). Granulovacuolar degeneration of the hippocampal pyramidal cells. Journal of Pathology 106, 165185.
Tomlinson, B. E., Blessed, G. & Roth, M. (1968). Observations on the brains of non-demented old people. Journal of Neurological Science 7, 331356.
Tomlinson, B. E., Blessed, G. & Roth, M. (1970). Observations on the brains of demented old people. Journal of Neurological Science 11, 205242.
Tomlinson, B. E., Irving, D. & Blessed, G. (1981). Cell loss in the locus coeruleus in senile dementia of Alzheimer type. Journal of Neurological Science 49, 419428.
Torack, R. M. & Lynch, R. G. (1981). Cytochemistry of brain amyloid in adult dementia. Acta neuropathologica 53, 189196.
Traub, R., Gajdusek, D. C. & Gibbs, C. J. Jr (1977). Transmissible virus dementia: The relation of transmissible spongiform encephalopathy to Creutzfeldtz–Jakob disease. In Aging and Dementia (ed. Smith, W. L. and Kinsbourne, M.), pp. 91152. Spectrum Publications: New York.
White, P., Hiley, C. R., Goodhardt, M. J., Carrasco, L. H., Keet, J. P., Williams, I. E. I. & Bowen, D. M. (1977). Neocortical cholinergic neurons in elderly people. Lancel, i, 668670.
Wisniewski, H. M. & Terry, R. D. (1967). Experimental colchicine encephalopathy. I. Introduction of neurofibrillary degeneration. Laboratory Investigation 17, 577587.
Wisniewski, H. M., Shelanski, M. L. & Terry, R. D. (1968). Effects of mitotic spindle inhibitors on neurotubules and neurofilaments in anterior horn cells. Journal of Cell Biology 38, 224229.
Wisniewski, H. M., Terry, R. D. & Hirano, A. (1970 a). Neurofibrillary pathology. Journal of Neuropathology and Experimental Neurology 29, 163176.
Wisniewski, H. M., Johnson, A. B., Raine, C. S., Kay, W. J. & Terry, R. D. (1970 b). Senile plaques and cerebral amyloidosis in aged dogs. A histochemical study. Laboratory Investigation 23, 287296.
Wisniewski, H. M., Ghetti, B. & Terry, R. D. (1973). Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. Journal of Neuropathology and Experimental Neurology 32, 566584.
Wisniewski, H. M., Bruce, M. E. & Fraser, H. (1975). Infectious aetiology of neuritic (senile) plaques in mice. Science 190, 11081110.
Wisniewski, H. M., Narang, H. K. & Terry, R. D. (1976 a). Neurofibrillary tangles of paired helical filaments. Journal of Neurological Science 27, 173181.
Wisniewski, H. M., Narang, H. K., Corsellis, J. A. N. & Terry, R. D. (1976 b). Ultrastructural studies of the neuropil and neurofibrillary tangles in Alzheimer's disease and post-traumatic dementia. Journal of Neuropathology and Experimental Neurology 35, 367.
Woodard, J. S. (1962). Clinico-pathological significance of granulo-vacuolar degeneration in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 21, 8591.
Woodard, J. S. (1966). Alzheimer's disease in late adult life. American Journal of Pathology 49, 11571169.
Wright, J. R., Calkins, E., Breen, W. T., Stolte, G. & Schultz, R. T. (1969). Relationship of amyloid to aging. Review of the literature and a systematic study of 83 patients derived from a general hospital population. Medicine 48, 3960.
Yagashita, S., Itah, Y., Wang, N. & Amano, N. (1981). Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles. Acta Neuropathologica (Berlin) 54, 239246.

Plaques, tangles and Alzheimer's disease1

  • B. E. Tomlinson

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed