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Obsessive-compulsive disorder and schizophrenia in three identical twin pairs

Published online by Cambridge University Press:  09 July 2009

S. W. Lewis ,
B. Chitkara  and
A. M. Revelely
S. W. Lewis*
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School, Institute of Psychiatry and Maudsley Hospital, London
B. Chitkara
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School, Institute of Psychiatry and Maudsley Hospital, London
A. M. Revelely
Affiliation:
Department of Psychiatry, Charing Cross and Westminster Medical School, Institute of Psychiatry and Maudsley Hospital, London
*
1Address for correspondence: Dr S. W. Lewis, Department of Psychiatry, Charing Cross and Westminster Medical School, St Dunstan's Road, London W6 8RP.
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Synopsis

Three monozygotic twin pairs are described who are concordant for DSM-III-R obsessive-compulsive disorder while being discordant for schizophrenia or schizoaffiective disorder. Follow-up interview showed the non-psychotic co-twins to have schizotypal personality disorder. It is concluded that obsessive-compulsive and schizophrenia-spectrum disorders can truly co-exits, thus supporting diagnostic changes introduced into DSM-III-R, and may in some cases be inherited together.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 1 , February 1991 , pp. 135 - 141
Copyright
Copyright © Cambridge University Press 1991

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