Skip to main content Accessibility help
×
Home

Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis

  • Sandra Vieira (a1), Qiyong Gong (a2) (a3) (a4), Cristina Scarpazza (a1) (a5), Su Lui (a2) (a3) (a4), Xiaoqi Huang (a2) (a3) (a4), Benedicto Crespo-Facorro (a6) (a7), Diana Tordesillas-Gutierrez (a6) (a8), Víctor Ortiz-García de la Foz (a6) (a7), Esther Setien-Suero (a6) (a7), Floor Scheepers (a9), Neeltje E.M. van Haren (a9), René Kahn (a9), Tiago Reis Marques (a1), Simone Ciufolini (a1), Marta Di Forti (a10), Robin M Murray (a1), Anthony David (a11), Paola Dazzan (a1), Philip McGuire (a1) and Andrea Mechelli (a1)...

Abstract

Background

Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples.

Methods

Structural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five sites. Voxel-based morphometry was used to investigate differences in grey matter volume (GMV) between the two groups. Statistical inferences were made at p < 0.05 after family-wise error correction for multiple comparisons.

Results

FEP showed a widespread pattern of decreased GMV in fronto-temporal, insular and occipital regions bilaterally; these decreases were not dependent on anti-psychotic medication. The region with the most pronounced decrease – gyrus rectus – was negatively correlated with the severity of positive and negative symptoms.

Conclusions

This study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis
      Available formats
      ×

Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

Author for correspondence: Qiyong Gong, E-mail: qiyonggong@hmrrc.org.cn

References

Hide All
Aas, M., Dazzan, P., Mondelli, V., Melle, I., Murray, R. M., & Pariante, C. M. (2014). A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation. Frontiers in Psychiatry, 4, 182. doi: 10.3389/fpsyt.2013.00182
Adler, C. M., Levine, A. D., DelBello, M. P., & Strakowski, S. M. (2005). Changes in gray matter volume in patients with bipolar disorder. Biological Psychiatry, 58(2), 151157. doi: 10.1016/J.BIOPSYCH.2005.03.022
Andreasen, N. C., Flaum, M., & Arndt, S. (1992). The Comprehensive Assessment of Symptoms and History (CASH). Archives of General Psychiatry, 49(8), 615. doi: 10.1001/archpsyc.1992.01820080023004
APA (2000). Diagnostic and statistical manual of mental disorders 4th edition (DSM-IV-TR). Washington, DC: American Psychiatric Association.
Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage, 38(1), 95113. doi: 10.1016/j.neuroimage.2007.07.007
Ashburner, J., & Friston, K. J. (2005). Unified segmentation. NeuroImage, 26(3), 839851. doi: 10.1016/j.neuroimage.2005.02.018
Barkl, S. J., Lah, S., Harris, A. W. F., & Williams, L. M. (2014). Facial emotion identification in early-onset and first-episode psychosis: A systematic review with meta-analysis. Schizophrenia Research, 159(1), 6269. doi: 10.1016/J.SCHRES.2014.07.049
Bebbington, P., & Nayani, T. (1995). The psychosis screening questionnaire. International Journal of Methods in Psychiatric Research, 5, 1119.
Benetti, S., Pettersson-Yeo, W., Allen, P., Catani, M., Williams, S., Barsaglini, A., … Mechelli, A. (2015). Auditory verbal hallucinations and brain disconnectivity in the Perisylvian language network: A multimodal investigation. Schizophrenia Bulletin, 41(1), 192200. doi: 10.1093/schbul/sbt172
Berger, G. E., Wood, S., & McGorry, P. D. (2003). Incipient neurovulnerability and neuroprotection in early psychosis. Psychopharmacology Bulletin, 37(2), 79101. Retrieved September 6, 2018, from http://www.ncbi.nlm.nih.gov/pubmed/14566217.
Bora, E., Fornito, A., Radua, J., Walterfang, M., Seal, M., Wood, S. J., … Pantelis, C. (2011). Neuroanatomical abnormalities in schizophrenia: A multimodal voxelwise meta-analysis and meta-regression analysis. Schizophrenia Research, 127(1–3), 4657. doi: 10.1016/J.SCHRES.2010.12.020
Buchanan, R. W., Francis, A., Arango, C., Miller, K., Lefkowitz, D. M., McMahon, R. P., … Pearlson, G. D. (2004). Morphometric assessment of the heteromodal association cortex in schizophrenia. American Journal of Psychiatry, 161(2), 322331. doi: 10.1176/appi.ajp.161.2.322
Butler, P. D., Silverstein, S. M., & Dakin, S. C. (2008). Visual perception and its impairment in schizophrenia. Biological Psychiatry, 64(1), 4047. doi: 10.1016/J.BIOPSYCH.2008.03.023
Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J., & Munafò, M. R. (2013). Power failure: Why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience, 14(5), 365376. doi: 10.1038/nrn3475
Chan, R. C. K., Di, X., McAlonan, G. M., & Gong, Q. (2011). Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: An activation likelihood estimation meta-analysis of illness progression. Schizophrenia Bulletin, 37(1), 177188. doi: 10.1093/schbul/sbp073
Chua, S. E., Cheung, C., Cheung, V., Tsang, J. T. K., Chen, E. Y. H., Wong, J. C. H., … McAlonan, G. M. (2007). Cerebral grey, white matter and CSF in never-medicated, first-episode schizophrenia. Schizophrenia Research, 89(1–3), 1221. doi: 10.1016/j.schres.2006.09.009
Contreras, N. A., Tan, E. J., Lee, S. J., Castle, D. J., & Rossell, S. L. (2018). Using visual processing training to enhance standard cognitive remediation outcomes in schizophrenia: A pilot study. Psychiatry Research, 262, 494499. doi: 10.1016/J.PSYCHRES.2017.09.031
Crespo-Facorro, B., Kim, J.-J., Andreasen, N. C., O'Leary, D. S., Bockholt, H. J., & Magnotta, V. (2000). Insular cortex abnormalities in schizophrenia: A structural magnetic resonance imaging study of first-episode patients. Schizophrenia Research, 46(1), 3543.
Crespo-Facorro, B., Kim, J.-J., Andreasen, N. C., O'Leary, D. S., & Magnotta, V. (2000). Regional frontal abnormalities in schizophrenia: A quantitative gray matter volume and cortical surface size study. Biological Psychiatry, 48(2), 110119.
Di Forti, M., Morgan, C., Dazzan, P., Pariante, C., Mondelli, V., Marques, T. R., … Murray, R. M. (2009). High-potency cannabis and the risk of psychosis. British Journal of Psychiatry, 195(06), 488491. doi: 10.1192/bjp.bp.109.064220
Eckert, M. A., Menon, V., Walczak, A., Ahlstrom, J., Denslow, S., Horwitz, A., & Dubno, J. R. (2009). At the heart of the ventral attention system: The right anterior insula. Human Brain Mapping, 30(8), 25302541. doi: 10.1002/hbm.20688
Ellison-Wright, I., & Bullmore, E. (2010). Anatomy of bipolar disorder and schizophrenia: A meta-analysis. Schizophrenia Research, 117(1), 112. doi: 10.1016/J.SCHRES.2009.12.022
Ellison-Wright, I., Glahn, D. C., Laird, A. R., Thelen, S. M., & Bullmore, E. (2008). The anatomy of first-episode and chronic schizophrenia: An anatomical likelihood estimation meta-analysis. American Journal of Psychiatry, 165(8), 10151023. doi: 10.1176/appi.ajp.2008.07101562
First, M. B., Gibbon, M., Spitzer, R. L., & Williams, J. (1997). Structured clinical interview for DSM-IV axis II personality disorders. Washington: American Psychiatric Press.
Frith, C. D., & Done, D. J. (1988). Towards a neuropsychology of schizophrenia. The British Journal of Psychiatry, 153(4), 437443.
Fusar-Poli, P., Placentino, A., Carletti, F., Landi, P., Allen, P., Surguladze, S., … Politi, P. (2009). Functional atlas of emotional faces processing: A voxel-based meta-analysis of 105 functional magnetic resonance imaging studies. Journal of Psychiatry & Neuroscience: JPN, 34(6), 418432. Retrieved September 5, 2018, from http://www.ncbi.nlm.nih.gov/pubmed/19949718.
Fusar-Poli, P., Radua, J., McGuire, P., & Borgwardt, S. (2012). Neuroanatomical maps of psychosis onset: Voxel-wise meta-analysis of antipsychotic-naive VBM studies. Schizophrenia Bulletin, 38(6), 12971307. doi: 10.1093/schbul/sbr134
Gao, X., Zhang, W., Yao, L., Xiao, Y., Liu, L., Liu, J., … Lui, S. (2018). Association between structural and functional brain alterations in drug-free patients with schizophrenia: A multimodal meta-analysis. Journal of Psychiatry & Neuroscience, 43(2), 131142. doi: 10.1503/jpn.160219
Gardner, D. M., Murphy, A. L., O'Donnell, H., Centorrino, F., & Baldessarini, R. J. (2010). International consensus study of antipsychotic dosing. American Journal of Psychiatry, 167(6), 686693. doi: 10.1176/appi.ajp.2009.09060802
Glahn, D. C., Laird, A. R., Ellison-Wright, I., Thelen, S. M., Robinson, J. L., Lancaster, J. L., … Fox, P. T. (2008). Meta-analysis of gray matter anomalies in schizophrenia: Application of anatomic likelihood estimation and network analysis. Biological Psychiatry, 64(9), 774781. doi: 10.1016/J.BIOPSYCH.2008.03.031
Gong, Q., Dazzan, P., Scarpazza, C., Kasai, K., Hu, X., Marques, T. R., … Mechelli, A. (2015). A neuroanatomical signature for schizophrenia across different ethnic groups. Schizophrenia Bulletin, 41(6), 12661275. doi: 10.1093/schbul/sbv109
Gong, Q., Scarpazza, C., Dai, J., He, M., Xu, X., Shi, Y., … Mechelli, A. (2019). A transdiagnostic neuroanatomical signature of psychiatric illness. Neuropsychopharmacology, 44(5), 869.
Green, M. F., Horan, W. P., & Lee, J. (2015). Social cognition in schizophrenia. Nature Reviews Neuroscience, 16(10), 620631. doi: 10.1038/nrn4005
Guo, S., Palaniyappan, L., Liddle, P. F., & Feng, J. (2016). Dynamic cerebral reorganization in the pathophysiology of schizophrenia: A MRI-derived cortical thickness study. Psychological Medicine, 46(10), 22012214. doi: 10.1017/S0033291716000994
Gupta, C. N., Calhoun, V. D., Rachakonda, S., Chen, J., Patel, V., Liu, J., … Buitelaar, J. (2014). Patterns of gray matter abnormalities in schizophrenia based on an international mega-analysis. Schizophrenia Bulletin, 41(5), 11331142. doi: 10.1093/schbul/sbu177.
Hahn, B., Ross, T. J., & Stein, E. A. (2006). Neuroanatomical dissociation between bottom–up and top–down processes of visuospatial selective attention. NeuroImage, 32(2), 842853. doi: 10.1016/j.neuroimage.2006.04.177
Haxby, J. V, Hoffman, E. A., & Gobbini, M. I. (2000). The distributed human neural system for face perception. Trends in Cognitive Sciences, 4(6), 223233
Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2002). Human neural systems for face recognition and social communication. Biological Psychiatry, 51(1), 5967.
Huang, P., Xi, Y., Lu, Z.-L., Chen, Y., Li, X., Li, W., … Yin, H. (2015). Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms: A volumetric MRI study. Scientific Reports, 5(1), 14505. doi: 10.1038/srep14505
Jayakumar, P. N., Venkatasubramanian, G., Gangadhar, B. N., Janakiramaiah, N., & Keshavan, M. S. (2005). Optimized voxel-based morphometry of gray matter volume in first-episode, antipsychotic-naïve schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(4), 587591. doi: 10.1016/J.PNPBP.2005.01.020
Johnson, W. E., Li, C., & Rabinovic, A. (2006). Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics (Oxford, England), 8(1), 118127.
Keymer-Gausset, A., Alonso-Solís, A., Corripio, I., Sauras-Quetcuti, R. B., Pomarol-Clotet, E., Canales-Rodriguez, E. J., … Portella, M. J. (2018). Gray and white matter changes and their relation to illness trajectory in first episode psychosis. European Neuropsychopharmacology, 28(3), 392400. doi: 10.1016/J.EURONEURO.2017.12.117
Kim, G.-W., Kim, Y.-H., & Jeong, G.-W. (2017). Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study. PLoS ONE. Edited by K. Hashimoto. Public Library of Science, 12(5), e0177251. doi: 10.1371/journal.pone.0177251.
Kim, J.-J., Crespo-Facorro, B., Andreasen, N. C., O'Leary, D. S., Magnotta, V., & Nopoulos, P. (2003). Morphology of the lateral superior temporal gyrus in neuroleptic naı̈ve patients with schizophrenia: Relationship to symptoms. Schizophrenia Research, 60(2–3), 173181. doi: 10.1016/S0920-9964(02)00299-2
Kong, L., Herold, C. J., Zöllner, F., Salat, D. H., Lässer, M. M., Schmid, L. A., … Schröder, J. (2015). Comparison of grey matter volume and thickness for analysing cortical changes in chronic schizophrenia: A matter of surface area, grey/white matter intensity contrast, and curvature. Psychiatry Research: Neuroimaging, 231(2), 176183. doi: 10.1016/J.PSCYCHRESNS.2014.12.004
Korver, N., Quee, P. J., Boos, H. B. M., Simons, C. J. P., & de Haan, L. (2012). Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: Objectives, sample characteristics, recruitment and assessment methods. International Journal of Methods in Psychiatric Research, 21(3), 205221. doi: 10.1002/mpr.1352
Kringelbach, M. L. (2005). The human orbitofrontal cortex: Linking reward to hedonic experience. Nature Reviews Neuroscience, 6(9), 691702. doi: 10.1038/nrn1747
Lee, H. W., Hong, S. B., Seo, D. W., Tae, W. S., & Hong, S. C. (2000). Mapping of functional organization in human visual cortex: Electrical cortical stimulation. Neurology. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology, 54(4), 849854. doi: 10.1212/WNL.54.4.849.
Lee, J. S., Park, H.-J., Chun, J. W., Seok, J.-H., Park, I.-H., Park, B., & Kim, J.-J. (2011). Neuroanatomical correlates of trait anhedonia in patients with schizophrenia: A voxel-based morphometric study. Neuroscience Letters, 489(2), 110114. doi: 10.1016/J.NEULET.2010.11.076
Liao, J., Yan, H., Liu, Q., Yan, J., Zhang, L., Jiang, S., … Wang, F. (2015). Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function. Journal of Psychiatric Research, 65, 8086. doi: 10.1016/J.JPSYCHIRES.2015.04.008
Mechelli, A., Allen, P., Amaro, E. Jr, Fu, C. H., Williams, S. C., Brammer, M. J., … McGuire, P. K. (2007). Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations. Human Brain Mapping, 28(11), 12131222.
Mechelli, A., Price, C. J., Friston, K. J., & Ashburner, J. (2005). Voxel-Based Morphometry of the Human Brain: Methods and Applications, Current Medical Imaging Reviews. doi: 10.2174/1573405054038726.
Meisenzahl, E. M., Koutsouleris, N., Bottlender, R., Scheuerecker, J., Jäger, M., Teipel, S. J., … Möller, H.-J. (2008). Structural brain alterations at different stages of schizophrenia: A voxel-based morphometric study. Schizophrenia Research, 104(1–3), 4460. doi: 10.1016/J.SCHRES.2008.06.023
Menon, V., & Uddin, L. Q. (2010). Saliency, switching, attention and control: A network model of insula function. Brain Structure & Function, 214(5–6), 655667. doi: 10.1007/s00429-010-0262-0
Modinos, G., Costafreda, S. G., van Tol, M.-J., McGuire, P. K., Aleman, A., & Allen, P. (2013). Neuroanatomy of auditory verbal hallucinations in schizophrenia: A quantitative meta-analysis of voxel-based morphometry studies. Cortex, 49(4), 10461055. doi: 10.1016/J.CORTEX.2012.01.009
Murray, G. K., Cheng, F., Clark, L., Barnett, J. H., Blackwell, A. D., Fletcher, P. C., … Jones, P. B. (2008). Reinforcement and reversal learning in first-episode psychosis. Schizophrenia Bulletin, 34(5), 848855. doi: 10.1093/schbul/sbn078
Nakamura, M., Nestor, P. G., Levitt, J. J., Cohen, A. S., Kawashima, T., Shenton, M. E., & McCarley, R. W. (2007). Orbitofrontal volume deficit in schizophrenia and thought disorder. Brain, 131(1), 180195. doi: 10.1093/brain/awm265
Olabi, B., Ellison-Wright, I., McIntosh, A. M., Wood, S. J., Bullmore, E., & Lawrie, S. M. (2011). Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies. Biological Psychiatry, 70(1), 8896. doi: 10.1016/J.BIOPSYCH.2011.01.032
Pelayo-Terán, J. M., Pérez-Iglesias, R., Ramírez-Bonilla, M., González-Blanch, C., Martínez-García, O., Pardo-García, G., … Crespo-Facorro, B. (2008). Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: Insights from the Clinical Programme on Early Phases of Psychosis. Early Intervention in Psychiatry, 2(3), 178187. doi: 10.1111/j.1751-7893.2008.00074.x.
Premkumar, P., Fannon, D., Sapara, A., Peters, E. R., Anilkumar, A. P., Simmons, A., … Kumari, V. (2015). Orbitofrontal cortex, emotional decision-making and response to cognitive behavioural therapy for psychosis. Psychiatry Research: Neuroimaging, 231(3), 298307. doi: 10.1016/J.PSCYCHRESNS.2015.01.013
Radewicz, K., Garey, L. J., Gentleman, S. M., & Reynolds, R. (2000). Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. Journal of Neuropathology & Experimental Neurology, 59(2), 137150. doi: 10.1093/jnen/59.2.137
Radua, J., Borgwardt, S., Crescini, A., Mataix-Cols, D., Meyer-Lindenberg, A., McGuire, P. K., & Fusar-Poli, P. (2012). Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication. Neuroscience & Biobehavioral Reviews, 36(10), 23252333. doi: 10.1016/j.neubiorev.2012.07.012
Ren, W., Lui, S., Deng, W., Li, F., Li, M., Huang, X., … Gong, Q. (2013). Anatomical and functional brain abnormalities in drug-naive first-episode schizophrenia. American Journal of Psychiatry, 170(11), 13081316. doi: 10.1176/appi.ajp.2013.12091148
Rimol, L. M., Nesvåg, R., Hagler, D. J., Bergmann, Ø, Fennema-Notestine, C., Hartberg, C. B., … Dale, A. M. (2012). Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder. Biological Psychiatry, 71(6), 552560. doi: 10.1016/J.BIOPSYCH.2011.11.026
Roiz-Santiáñez, R., Pérez-Iglesias, R., Ortiz-García de la Foz, V., Tordesillas-Gutiérrez, D., Mata, I., Marco de Lucas, E., … Crespo-Facorro, B. (2011). Straight gyrus morphology in first-episode schizophrenia-spectrum patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(1), 8490. doi: 10.1016/J.PNPBP.2010.09.002
Rozycki, M., Satterthwaite, T. D., Koutsouleris, N., Erus, G., Doshi, J., Wolf, D. H., … Davatzikos, C. (2018). Multisite machine learning analysis provides a robust structural imaging signature of schizophrenia detectable across diverse patient populations and within individuals. Schizophrenia Bulletin, 44(5), 10351044. doi: 10.1093/schbul/sbx137
Salgado-Pineda, P., Baeza, I., Pérez-Gómez, M., Vendrell, P., Junqué, C., Bargalló, N., & Bernardo, M. (2003). Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients. NeuroImage, 19(2), 365375. doi: 10.1016/S1053-8119(03)00094-6
Sans-Sansa, B., McKenna, P. J., Canales-Rodríguez, E. J., Ortiz-Gil, J., López-Araquistain, L., Sarró, S., … Pomarol-Clotet, E. (2013). Association of formal thought disorder in schizophrenia with structural brain abnormalities in language-related cortical regions. Schizophrenia Research, 146(1–3), 308313. doi: 10.1016/J.SCHRES.2013.02.032
Schoenbaum, G., Roesch, M. R., Stalnaker, T. A., & Takahashi, Y. K. (2009). A new perspective on the role of the orbitofrontal cortex in adaptive behaviour. Nature Reviews Neuroscience, 10(12), 885892. doi: 10.1038/nrn2753
Shah, C., Zhang, W., Xiao, Y., Yao, L., Zhao, Y., Gao, X., … Lui, S. (2017). Common pattern of gray-matter abnormalities in drug-naive and medicated first-episode schizophrenia: A multimodal meta-analysis. Psychological Medicine, 47(03), 401413. doi: 10.1017/S0033291716002683
Silverstein, S. M., & Keane, B. P. (2011). Perceptual organization impairment in schizophrenia and associated brain mechanisms: Review of research from 2005 to 2010. Schizophrenia Bulletin, 37(4), 690699. doi: 10.1093/schbul/sbr052
Smieskova, R., Fusar-Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R. D., Drewe, J., … Borgwardt, S. J. (2010). Neuroimaging predictors of transition to psychosis – a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 34(8), 12071222. doi: 10.1016/J.NEUBIOREV.2010.01.016
Strauss, G. P., Waltz, J. A., & Gold, J. M. (2014). A review of reward processing and motivational impairment in schizophrenia. Schizophrenia Bulletin, 40(Suppl 2), S107S116. doi: 10.1093/schbul/sbt197
Surti, T. S., Corbera, S., Bell, M. D., & Wexler, B. E. (2011). Successful computer-based visual training specifically predicts visual memory enhancement over verbal memory improvement in schizophrenia. Schizophrenia Research, 132(2–3), 131134. doi: 10.1016/j.schres.2011.06.031
Surti, T. S., & Wexler, B. E. (2012). A pilot and feasibility study of computer-based training for visual processing deficits in schizophrenia. Schizophrenia Research, 142(1–3), 248249. doi: 10.1016/j.schres.2012.09.013
Szendi, I., Kiss, M., Racsmány, M., Boda, K., Cimmer, C., Vörös, E., … Janka, Z. (2006). Correlations between clinical symptoms, working memory functions and structural brain abnormalities in men with schizophrenia. Psychiatry Research: Neuroimaging, 147(1), 4755. doi: 10.1016/J.PSCYCHRESNS.2005.05.014
Takayanagi, Y., Takahashi, T., Orikabe, L., Mozue, Y., Kawasaki, Y., Nakamura, K., … Suzuki, M. (2011). Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness. PLoS ONE. Edited by B. J. Harrison. Public Library of Science, 6(6), 110. doi: 10.1371/journal.pone.0021047
Tang, J., Liao, Y., Zhou, B., Tan, C., Liu, W., Wang, D., … Chen, X. (2012). Decrease in temporal gyrus gray matter volume in first-episode, early onset schizophrenia: An MRI study. PLoS ONE. Edited by A. Bruce. Public Library of Science, 7(7), e40247. doi: 10.1371/journal.pone.0040247.
Taylor, J. L., Blanton, R. E., Levitt, J. G., Caplan, R., Nobel, D., & Toga, A. W. (2005). Superior temporal gyrus differences in childhood-onset schizophrenia. Schizophrenia Research, 73(2–3), 235241. doi: 10.1016/J.SCHRES.2004.07.023
Tordesillas-Gutierrez, D., Koutsouleris, N., Roiz-Santiañez, R., Meisenzahl, E., Ayesa-Arriola, R., Marco de Lucas, E., … Crespo-Facorro, B. (2015). Grey matter volume differences in non-affective psychosis and the effects of age of onset on grey matter volumes: A voxelwise study. Schizophrenia Research, 164(1–3), 7482. doi: 10.1016/J.SCHRES.2015.01.032
van Erp, T. G., Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., … Melle, I. (2016). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry, 21(4), 547553. doi: 10.1038/mp.2015.63
Van Erp, T. G., Walton, E., Hibar, D. P., Schmaal, L., Jiang, W., Glahn, D. C., … Okada, N. (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) consortium. Biological Psychiatry, 84(9), 644654. doi: 10.1016/J.BIOPSYCH.2018.04.023
van Erp, T. G. M., Preda, A., Nguyen, D., Faziola, L., Turner, J., Bustillo, J., … FBIRN (2014). Converting positive and negative symptom scores between PANSS and SAPS/SANS. Schizophrenia Research, 152(1), 289294. doi: 10.1016/J.SCHRES.2013.11.013.
Venkatasubramanian, G. (2010). Neuroanatomical correlates of psychopathology in antipsychotic-naïve schizophrenia. Indian Journal of Psychiatry, 52(1), 2836. doi: 10.4103/0019-5545.58892
Vita, A., De Peri, L., Deste, G., Barlati, S., & Sacchetti, E. (2015). The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: Does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies. Biological Psychiatry, 78(6), 403412. doi: 10.1016/J.BIOPSYCH.2015.02.008
Vita, A., De Peri, L., Deste, G., & Sacchetti, E. (2012). Progressive loss of cortical gray matter in schizophrenia: A meta-analysis and meta-regression of longitudinal MRI studies. Translational Psychiatry, 2(11), e190. doi: 10.1038/tp.2012.116
WHO (2004). International statistical classification of diseases and related health problems. World Health Organization.
Wylie, K. P., & Tregellas, J. R. (2010). The role of the insula in schizophrenia. Schizophrenia Research, 123(2–3), 93104. doi: 10.1016/J.SCHRES.2010.08.027
Xu, Y., Qin, W., Zhuo, C., Xu, L., Zhu, J., Liu, X., & Yu, C.(2017). Selective functional disconnection of the orbitofrontal subregions in schizophrenia. Psychological Medicine, 47(09), 16371646. doi: 10.1017/S0033291717000101
Yassa, M., & Stark, C. (2009). A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. NeuroImage, 44(2), 319327. doi: 10.1016/j.neuroimage.2008.09.016

Keywords

Type Description Title
WORD
Supplementary materials

Vieira et al. supplementary material
Vieira et al. supplementary material

 Word (24.1 MB)
24.1 MB

Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis

  • Sandra Vieira (a1), Qiyong Gong (a2) (a3) (a4), Cristina Scarpazza (a1) (a5), Su Lui (a2) (a3) (a4), Xiaoqi Huang (a2) (a3) (a4), Benedicto Crespo-Facorro (a6) (a7), Diana Tordesillas-Gutierrez (a6) (a8), Víctor Ortiz-García de la Foz (a6) (a7), Esther Setien-Suero (a6) (a7), Floor Scheepers (a9), Neeltje E.M. van Haren (a9), René Kahn (a9), Tiago Reis Marques (a1), Simone Ciufolini (a1), Marta Di Forti (a10), Robin M Murray (a1), Anthony David (a11), Paola Dazzan (a1), Philip McGuire (a1) and Andrea Mechelli (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed