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Modification of the noradrenaline related effects of smoking by beta-blockade

Published online by Cambridge University Press:  09 July 2009

Malcolm Carruthers
Malcolm Carruthers
Affiliation:
Department of Chemical Pathology (Research), St Mary's Hospital Medical School, London
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Synopsis

Increases in plasma noradrenaline were found in a group of 12 subjects smoking cigarettes. The associated rises in pulse rate, blood pressure and plasma free fatty acids could be prevented by β-blockade with oxprenolol. This inhibition of the peripheral effects of catecholamines did not affect subjective satisfaction, indicating that central effects or other rewards are more important reinforcers. It is suggested that noradrenaline release in the hypothalamus is the final common pathway to pleasure in many situations, including smoking.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 2 , May 1976 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1976

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