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A longitudinal study of personality and major depression in a population-based sample of male twins

  • AYMAN H. FANOUS (a1) (a2) (a3), MICHAEL C. NEALE (a3), STEVEN H. AGGEN (a3) and KENNETH S. KENDLER (a3)



The relationship between personality and psychiatric illness is complex. It is not clear whether one directly causes the other.


In a population-based sample of male twins (n=3030), we attempted to predict major depression (MD) from neuroticism (N) and extraversion (E) and vice versa, to evaluate the causal, scar, state, and prodromal hypotheses. In a longitudinal, structural equation twin model, we decomposed the covariation between N and MD into (a) genetic and environmental factors that are common to both traits, as well as specific to each one and (b) direct causal effects of N at time 1 on subsequent MD, as well as between MD and subsequent N.


E was negatively correlated with lifetime and one-year prevalence of MD. N predicted the new onset of MD, and was predicted by both current and past MD. It did not predict the time to onset of MD. All of the covariation between N and MD was due to additive genetic and individual-specific environmental factors shared by both traits and a direct causal path between MD and N assessed later. No genetic factors were unique to either trait.


In men, N may be a vulnerability factor for MD but does not cause it directly. However, MD may have a direct causal effect on N. The genetic overlap between N and MD in men may be greater than in women.


Corresponding author

*Address for correspondence: Ayman H. Fanous, M.D., Washington VA Medical Center, 50 Irving St NW, Washington, DC 20422, USA. (Email:


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Abkevich, V., Camp, N. J., Hensel, C. H., Neff, C. D., Russell, D. L., Hughes, D. C., Plenk, A. M., Lowry, M. R., Richards, R. L., Carter, C., Frech, G. C., Stone, S., Rowe, K., Chau, C. A., Cortado, K., Hunt, A., Luce, K., O'Neil, G., Poarch, J., Potter, J., Poulsen, G. H., Saxton, H., Bernat-Sestak, M., Thompson, V., Gutin, A., Skolnick, M. H., Shattuck, D. & Cannon-Albright, L. (2003). Predisposition locus for major depression at chromosome 12q22-12q23.2. American Journal of Human Genetics 73, 12711281.
Akaike, H. (1987). Factor analysis and AIC. Psychometrika 52, 317332.
Akiskal, H. S. & Pinto, O. (1999). The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatric Clinics of North America 22, 517534, vii.
Akiskal, H. S., Hirschfeld, R. M. & Yerevanian, B. I. (1983). The relationship of personality to affective disorders. Archives of General Psychiatry 40, 801810.
Bartholomew, A. A. (1959). The temporal reliability of the Maudsley Personality Inventory. Journal of Mental Science 105, 238240.
Boyce, P. & Parker, G. (1985). Neuroticism as a predictor of outcome in depression. Journal of Nervous and Mental Disease 173, 685688.
Boyce, P., Parker, G., Barnett, B., Cooney, M. & Smith, F. (1991). Personality as a vulnerability factor to depression. British Journal of Psychiatry 159, 106114.
Burnham, K. P. & Anderson, D. R. (1998). Model Selection and Inference: a Practical Information – Theoretic Approach. Springer-Verlag: New York.
Coppen, A. (1965). Effects of a depressive illness on MPI scores. British Journal of Psychiatry 111, 236239.
Cox, W. M. (1985). Personality correlates of substance abuse. In Determinants of Substance Abuse: Biological, Psychological, and Environmental Factors (ed. Galizio, M. and Maisto, S. A.), pp. 209246. Plenum Press: New York.
Czerwinski, S. A., Mahaney, M. C., Williams, J. T., Almasy, L. & Blangero, J. (1999). Genetic analysis of personality traits and alcoholism using a mixed discrete continuous trait variance component model. Genetic Epidemiology 17 (suppl. 1), S121S126.
Duggan, C. F., Lee, A. S. & Murray, R. M. (1990). Does personality predict long-term outcome in depression? British Journal of Psychiatry 157, 1924.
Duggan, C. F., Sham, P., Lee, A. S. & Murray, R. M. (1991). Does recurrent depression lead to a change in neuroticism? Psychological Medicine 21, 985990.
Eysenck, H. J. & Eysenck, S. B. G. (1975). Manual of the Eysenck Personality Questionnaire. Hodder & Stoughton: London.
Eysenck, H. J. & Eysenck, M. W. (1985). Personality and Individual Differences. A Natural Science Approach. Plenum Press: New York.
Fanous, A., Gardner, C. O., Prescott, C. A., Cancro, R. & Kendler, K. S. (2002). Neuroticism, major depression and gender: a population-based twin study. Psychological Medicine 32, 719728.
Farmer, A., Redman, K., Harris, T., Mahmood, A., Sadler, S., Pickering, A. & McGuffin, P. (2002). Neuroticism, extraversion, life events and depression. The Cardiff Depression Study. British Journal of Psychiatry 181, 118122.
Floderus-Myrhed, B., Pedersen, N. & Rasmuson, I. (1980). Assessment of heritability for personality, based on a short-form of the Eysenck Personality Inventory: a study of 12898 twin pairs. Behavior Genetics 10, 153162.
Gottesman, I. I. & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636645.
Hirschfeld, R. M. & Cross, C. K. (1983). Personality, life events, and social factors in depression. In Psychiatry Update: The American Psychiatric Association Annual Review (ed. Grinspoon, L.), pp. 382405. American Psychiatric Press: Washington, DC.
Hirschfeld, R. M., Klerman, G. L., Clayton, P. J. & Keller, M. B. (1983 b). Personality and depression. Empirical findings. Archives of General Psychiatry 40, 993998.
Hirschfeld, R. M., Klerman, G. L., Clayton, P. J., Keller, M. B., McDonald-Scott, P. & Larkin, B. H. (1983 a). Assessing personality: effects of the depressive state on trait measurement. American Journal of Psychiatry 140, 695699.
Hirschfeld, R. M., Klerman, G. L., Lavori, P., Keller, M. B., Griffith, P. & Coryell, W. (1989). Premorbid personality assessments of first onset of major depression. Archives of General Psychiatry 46, 345350.
Jackson, S. W. (1986). Melancholia and Depression: From Hippocratic Times to Modern Times. Yale University Press: New Haven, CT.
Jang, K. L., Livesley, W. J. & Vernon, P. A. (1996). Heritability of the big five personality dimensions and their facets: a twin study. Journal of Personality 64, 577591.
Katz, R. & McGuffin, P. (1987). Neuroticism in familial depression. Psychological Medicine 17, 155161.
Kendler, K. S. & Gardner, C. O. Jr. (1998). Boundaries of major depression: an evaluation of DSM-IV criteria. American Journal of Psychiatry 155, 172177.
Kendler, K. S. & Prescott, C. A. (1999). A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry 56, 3944.
Kendler, K. S., Gardner, C. O., Neale, M. C. & Prescott, C. A. (2001). Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychological Medicine 31, 605616.
Kendler, K. S., Karkowski, L. M., Neale, M. C. & Prescott, C. A. (2000). Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Archives of General Psychiatry 57, 261269.
Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C. & Eaves, L. J. (1992). A population-based twin study of major depression in women. The impact of varying definitions of illness. Archives of General Psychiatry 49, 257266.
Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C. & Eaves, L. J. (1993). A longitudinal twin study of personality and major depression in women. Archives of General Psychiatry 50, 853862.
Kendler, K. S., Neale, M. C. & Walsh, D. (1995). Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. American Journal of Psychiatry 152, 749754.
Kerr, T. A., Schapira, K., Roth, M. & Garside, R. F. (1970). The relationship between the Maudsley Personality Inventory and the course of affective disorders. British Journal of Psychiatry 116, 1119.
Kessler, R. C., McGonagle, K. A., Zhao, S., Nelson, C. B., Hughes, M., Eshleman, S., Wittchen, H. U. & Kendler, K. S. (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51, 819.
Kraepelin, E. (1921). Manic-Depressive Illness and Paranoia. E & S Livingstone: Edinburgh, UK.
Kretschmer, E. (1936). Physique and Character. Kegan Paul Trench Trubner & Co.: London.
Krieg, J. C., Lauer, C. J., Hermle, L., von Bardeleben, U., Pollmacher, T. & Holsboer, F. (1990). Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results. Neuropsychobiology 23, 5767.
Kring, A. M. & Gordon, A. H. (1998). Sex differences in emotion: expression, experience, and physiology. Journal of Personality and Social Psychology 74, 686703.
Lauer, C. J., Bronisch, T., Kainz, M., Schreiber, W., Holsboer, F. & Krieg, J. C. (1997). Pre-morbid psychometric profile of subjects at high familial risk for affective disorder. Psychological Medicine 27, 355362.
Macaskill, G. T., Hopper, J. L., White, V. & Hill, D. J. (1994). Genetic and environmental variation in Eysenck Personality Questionnaire scales measured on Australian adolescent twins. Behavior Genetics 24, 481491.
Maier, W., Lichtermann, D., Minges, J. & Heun, R. (1992). Personality traits in subjects at risk for unipolar major depression: a family study perspective. Journal of Affective Disorders 24, 153163.
Maier, W., Minges, J., Lichtermann, D., Franke, P. & Gansicke, M. (1995). Personality patterns in subjects at risk for affective disorders. Psychopathology 28 (suppl. 1), 5972.
Mezey, A. G., Cohen, S. I. & Knight, E. J. (1963). Personality assessment under varying physiological and psychological conditions. Journal of Psychosomatic Research 7, 237240.
Neale, M. C. & Cardon, L. R. (1992). Methodology for Genetic Studies of Twins and Families. Kluwer Academic: Dordrecht, The Netherlands.
Neale, M. C. & Eaves, L. J. (1993). Estimating and controlling for the effects of volunteer bias with pairs of relatives. Behavior Genetics 23, 271277.
Neale, M. C., Boker, S. M., Xie, G. & Maes, H. H. (1999). Mx: Statistical Modeling, 5th edn. Medical College of Virginia of Virginia Commonwealth University, Department of Psychiatry: Richmond, VA.
Nurnberger, J. I. Jr., Foroud, T., Flury, L., Su, J., Meyer, E. T., Hu, K., Crowe, R., Edenberg, H., Goate, A., Bierut, L., Reich, T., Schuckit, M. & Reich, W. (2001). Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. American Journal of Psychiatry 158, 718724.
Nystrom, S. & Lindegard, B. (1975). Predisposition for mental syndromes: a study comparing predisposition for depression, neurasthenia and anxiety state. Acta Psychiatrica Scandanavica 51, 6976.
Ouimette, P. C., Klein, D. N. & Pepper, C. N. (1992). Personality traits in offspring of parents with unipolar affective disorder: an exploratory study. Journal of Affective Disorders 1, 9198.
Regier, D. A., Boyd, J. H., Burke, J. D. Jr., Rae, D. S., Myers, J. K., Kramer, M., Robins, L. N., George, L. K., Karno, M. & Locke, B. Z. (1988). One-month prevalence of mental disorders in the United States. Based on five Epidemiologic Catchment Area sites. Archives of General Psychiatry 45, 977986.
Riley, B. P. & McGuffin, P. (2000). Linkage and associated studies of schizophrenia. American Journal of Medical Genetics 97, 2344.
Schneider, K. (1958). Psychopathic Personalities. Cassell: London.
Sher, K. J. & Trull, T. J. (1994). Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder. Journal of Abnormal Psychology 103, 92102.
Siever, L. J., Kalus, O. F. & Keefe, R. S. (1993). The boundaries of schizophrenia. Psychiatric Clinics of North America 16, 217244.
Spitzer, R. L., Williams, J. B. & Gibbon, J. (1987). Structured Clinical Interview for DSM-III-R Patient Version. New York Psychiatric Institute: New York.
Tambs, K., Sundet, J. M., Eaves, L., Solaas, M. H. & Berg, K. (1991). Pedigree analysis of Eysenck Personality Questionnaire (EPQ) scores in monozygotic (MZ) twin families. Behavior Genetics 21, 369382.
Viken, R. J., Rose, R. J., Kaprio, J. & Koskenvuo, M. (1994). A developmental genetic analysis of adult personality: extraversion and neuroticism from 18 to 59 years of age. Journal of Personality and Social Psychology 66, 722730.
Weissman, M. M., Bland, R., Joyce, P. R., Newman, S., Wells, J. E. & Wittchen, H. U. (1993). Sex differences in rates of depression: cross-national perspectives. Journal of Affective Disorders 29, 7784.
Weissman, M. M., Prusoff, B. A. & Klerman, G. L. (1978). Personality and the prediction of long-term outcome of depression. American Journal of Psychiatry 135, 797800.
Wetzel, R. D., Cloninger, C. R., Hong, B. & Reich, T. (1980). Personality as a subclinical expression of the affective disorders. Comprehensive Psychiatry 21, 197205.
Zeiss, A. M. & Lewinsohn, P. M. (1988). Enduring deficits after remissions of depression: a test of the scar hypothesis. Behavioral Research Therapy 26, 151158.

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A longitudinal study of personality and major depression in a population-based sample of male twins

  • AYMAN H. FANOUS (a1) (a2) (a3), MICHAEL C. NEALE (a3), STEVEN H. AGGEN (a3) and KENNETH S. KENDLER (a3)


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