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Lithium therapy and thyroid function: a long-term study

  • J. H. Lazarus (a1), R. John (a1), E. H. Bennie (a1), R. J. Chalmers (a1) and G. Crockett (a1)...


Seventy-three patients who had been continuously receiving lithium carbonate for 6 months or more had their thyroid function evaluated clinically and biochemically. Goitre was found in 37 %, exophthalmos in 23 %, positive thyroid auto-antibodies in 24 % and abnormal TRH tests in 49 %. It would appear that thyroid failure due to lithium is usually dependent on antibody mediated damage. It is unlikely that lithium has a direct effect on the hypothalamic–pituitary axis.


Corresponding author

1Address for Correspondence: Dr J. H. Lazarus, Department of Medicine, University Hospital of Wales, Cardiff.


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Lithium therapy and thyroid function: a long-term study

  • J. H. Lazarus (a1), R. John (a1), E. H. Bennie (a1), R. J. Chalmers (a1) and G. Crockett (a1)...


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