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Life events, depressive relapse and maintenance treatment

Published online by Cambridge University Press:  09 July 2009

E. S. Paykel*
Affiliation:
St George's Hospital and Medical School, London
J. Tanner
Affiliation:
St George's Hospital and Medical School, London
*
1Address for correspondence: Dr E. S. Paykel, Department of Psychiatry, St George's Hospital, London SW 17.

Synopsis

Occurrence of life events was recorded in 30 recovered depressed women undergoing clinical relapse in a controlled trial of maintenance treatment with amitriptyline and psychotherapy, and in 30 matched patients who did not relapse. Overall, patients who relapsed experienced significantly more life events in the three months before relapse, and especially in the month immediately preceding it. Undesirable events were particularly implicated. Event rates prior to relapse were closely comparable in treatment subgroups, giving no evidence that differential stress was required to produce relapse. The findings reinforce previous studies indicating an overall relationship between life events of certain types and depression, but do not suggest that the beneficial effects of maintenance treatment are specifically protective against life stress.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1976

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References

REFERENCES

Brown, G. W. & Birley, J. L. T. (1968). Crises and life change and the onset of schizophrenia. Journal of Health and Social Behaviour 9, 203214.CrossRefGoogle Scholar
Brown, G. W., Harris, T. D. & Peto, J. (1973). Life events and psychiatric disorders. Part 2: nature of causal link. Psychological Medicine 3, 159176.CrossRefGoogle Scholar
Klerman, G. L., DiMascio, A., Weissman, M. M., Prusoff, B. A. & Paykel, E. S. (1974). Treatment of depression by drugs and psychotherapy. American Journal of Psychiatry 131, 186191.CrossRefGoogle ScholarPubMed
Leff, J. P., Hirsch, S. R., Gaind, R., Rohde, P. D. & Stevens, B. (1973). Life events and maintenance therapy in schizophrenic relapse. British Journal of Psychiatry 123, 659660.CrossRefGoogle ScholarPubMed
Mindham, R. H. S. (1974). Pharmacological aspects of the treatment of depression.Paper presented at the World Psychiatric Association Symposium on Special Problems in Psychiatry,London,November1113.Google Scholar
Paykel, E. S. (1974). Recent life events and clinical depression. In Life Stress and Illness (ed. Gunderson, E. K. & Rahe, R. H.) chapter 9, pp. 134163. Charles C. Thomas: Springfield, Illinois.Google Scholar
Paykel, E. S. (1975). Environmental variables in the aetiology of depression. In The Nature and Treatment of Depression (ed. Flach, F. L. & Draghi, S.) chapter 5, pp. 5772. John Wiley & Sons: New York.Google Scholar
Paykel, E. S., Myers, J. K., Dienelt, M. N., Klerman, G. L., Lindenthal, J. J. & Pepper, M. P. (1969). Life events and depression: a controlled study. Archives of General Psychiatry 21, 753760.CrossRefGoogle ScholarPubMed
Paykel, E. S., DiMascio, A., Haskell, D. & Prusoff, B. A. (1975 a). Effects of maintenance amitriptyline and psychotherapy on symptoms of depression. Psychological Medicine 5, 6777.CrossRefGoogle ScholarPubMed
Paykel, E. S., Prusoff, B. A. & Myers, J. K. (1975 b). Suicide attempts and recent life events: a controlled comparison. Archives of General Psychiatry 32, 327333.CrossRefGoogle ScholarPubMed
Siegel, S. (1956). Non-parametric Statistics for the Behavioural Sciences. McGraw Hill: New York.Google Scholar
Weissman, M. M., Klerman, G. L., Paykel, E. S., Prusoff, B. A. & Hanson, B. (1974). Treatment effects on the social adjustment of depressed outpatients. Archives of General Psychiatry 30, 771778.CrossRefGoogle Scholar