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        Letter to the Editor: Postpartum psychosis and pre-eclamptic toxaemia: a reply
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        Letter to the Editor: Postpartum psychosis and pre-eclamptic toxaemia: a reply
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Brockington (2016) highlights the co-occurrence of eclampsia and postpartum psychosis as an important diagnostic consideration. We agree and have described in our previous work the importance of performing thorough physical, neurological and laboratory examinations of every patient with first-onset postpartum psychosis as this might lead to a diagnosis with treatable causes and co-morbidities (Bergink et al. 2015b ). In addition to eclampsia, clinicians should consider the postpartum occurrence of autoimmune disorders (e.g. thyroiditis), encephalitis (e.g. NMDA encephalitis), infections (e.g. endometritis, mastitis) and rare inborn errors of metabolism.

Most women with first-onset postpartum psychosis will exhibit one of two disease courses (Bergink et al. 2015a ): an isolated postpartum psychosis with vulnerability to affective psychosis only after birth or postpartum psychosis as an expression of bipolar mood disorder with non-perinatal episodes (Chaudron & Pies, 2003; Di Florio et al. in press). The diagnostic criteria for puerperal bipolar disorder and Donkin psychosis as described by Brockington (2016) have neither been validated nor field tested, and therefore are not currently suitable for implementation in population-based epidemiological studies.

References

Bergink, V, Boyce, P, Munk-Olsen, T (2015 a). Postpartum psychosis: a valuable misnomer. Australian and New Zealand Journal of Psychiatry 49, 102103.
Bergink, V, Burgerhout, KM, Koorengevel, KM, Kamperman, AM, Hoogendijk, WJ, Lambregtse-van den Berg, MP, Kushner, SA (2015 b). Treatment of psychosis and mania in the postpartum period. American Journal of Psychiatry 172, 115123.
Brockington, I (2016). Postpartum psychosis and pre-eclamptic toxaemia [Letter]. Psychological Medicine. doi: 10.1017/S0033291716001173.
Chaudron, LH, Pies, RW (2003). The relationship between postpartum psychosis and bipolar disorder: a review. Journal of Clinical Psychiatry 64, 12841292.
Di Florio, A, Munk-Olsen, T, Bergink, V (in press). The birth of a psychiatric orphan disorder: postpartum psychosis. Lancet Psychiatry.