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Lack of effect of naloxone and schizophrenic auditory hallucinations

  • C. P. L. Freeman (a1) and C. G. Fairburn (a1)

Synopsis

Opiate-like neuropeptides, such as beta endorphin, have been implicated in the aetiology of schizophrenic symptoms; and the relief of some symptoms, particularly auditory hallucinations, has been reported after injection of naloxone. An opiate antagonist, naloxone 1·6 mg, and placebo were administered in a double-blind, crossover design to 13 constantly hallucinating schizophrenic patients. Naloxone was found to be no different from placebo in its effect.

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Corresponding author

1Address for correspondence: Dr C. P. L. Freeman, University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.

References

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